LIM/07 - Laboratório de Gastroenterologia Clínica e Experimental

O Laboratório de Gastroenterologia e Clínica Experimental é ligado ao Departamento de Gastroenterologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: doenças inflamatórias, autoimunes e funcionais do intestino: genética, etiopatogenia, imunologia e epidemiologia, doença celíaca: imunologia e epidemiologia; quantificação do glúten em alimentos; nano partículas e micropartículas em processo inflamatório intestinal; modelos experimentais de colite; hepatites virais, cirroses e suas complicações e hepatopatias; doença hepática gordurosa; obesidade; estresse oxidativo e síndrome metabólica.

Site oficial: http://limhc.fm.usp.br/portal/lim07-laboratorio-de-gastroenterologia-clinica-e-experimental/

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Recent Submissions

  1. Investigation of etiology of community-acquired pneumonia in hospitalized patients in a tertiary hospital of Sao Paulo City, Brazil

    BRAZILIAN JOURNAL OF INFECTIOUS DISEASES, v.27, n.6, article ID 103690, 6p, 2023

    Background: Community-Acquired Pneumonia (CAP) is the primary cause of hospitalization in the United States and the third leading cause of death in Brazil. The gold standard for diagnosing the etiology of CAP includes blood culture, Gram-stained sputum, and sputum culture. However, these methods ...

  2. Core Promoter and Pre-Core Variants of the Hepatitis B Virus (HBV) Are Frequent in Chronic Hepatitis B HBeAg-Negative Patients Infected by Genotypes A and D

    VIRUSES-BASEL, v.15, n.12, article ID 2339, 11p, 2023

    In Brazil, hepatitis B virus endemicity is low, moderate, or high in some areas, such as Espirito Santo State in the southeast region. In this study, we intend to characterize the basal core promoter (BCP) and pre-core region (PC) variants and their association with clinical/epidemiological disea...

  3. Clinical Aspects and Etiologic Investigation of Pediatric Patients With Acute Liver Failure

    TRANSPLANTATION PROCEEDINGS, v.55, n.9, 2023

    A new outbreak of hepatitis of unknown origin raised awareness in the international community. A few reports have attempted to associate new cases with adenovirus infection and the immunologic effects of previous SARS-CoV-2 infections through a superantigen mechanism. Moreover, according to a cas...

  4. Lysosomal Acid Lipase Deficiency in the Etiological Investigation of Cryptogenic Liver Disease in Adults: A Multicenter Brazilian Study

    GASTROENTEROLOGY INSIGHTS, v.14, n.4, p.564-574, 2023

    Background: Lysosomal acid lipase deficiency (LAL-D) is a rare genetic disease associated with the deregulation of lipid metabolism, leading to atherosclerosis, dyslipidemia, and hepatic steatosis, with potential progression to cirrhosis. Our study aims to assess the role of LAL-D in the setting ...

  5. Liver transplantation in Latin America: reality and challenges

    LANCET REGIONAL HEALTH-AMERICAS, v.28, article ID 100633, 13p, 2023

    Healthcare systems in Latin America are broadly heterogeneous, but all of them are burdened by a dramatic rise in liver disease. Some challenges that these countries face include an increase in patients requiring a transplant, insufficient rates of organ donation, delayed referral, and inequitabl...

  6. Evaluation of oxidative stress in an experimental model of Crohn's disease treated with hyperbaric oxygen therapy

    CLINICS, v.78, article ID 100305, 9p, 2023

    Introduction: Treatments of Inflammatory Bowel Disease (IBD) are able to control symptoms in most cases, how-ever, a fraction of patients do not improve or have a loss of response to treatments, making it important to explore new therapeutic strategies. Hyperbaric oxygen therapy (HBO) may represe...

  7. Neoadjuvant and adjuvant systemic treatment for hepatocellular carcinoma

    HEPATOMA RESEARCH, v.7, article ID 67, 12p, 2021

    Hepatocellular carcinoma (HCC) is a highly lethal malignancy, and few patients are candidates for curative-intended therapies. The mainstay of curative treatment in HCC is surgical resection, ablation, and transplantation. However, rates of recurrence are high, and there is no established approac...

  8. COVID-19 induces more pronounced extracellular matrix deposition than other causes of ARDS

    RESPIRATORY RESEARCH, v.24, n.1, article ID 281, 11p, 2023

    BackgroundLung fibrosis is a major concern in severe COVID-19 patients undergoing mechanical ventilation (MV). Lung fibrosis frequency in post-COVID syndrome is highly variable and even if the risk is proportionally small, many patients could be affected. However, there is still no data on lung e...

  9. Association of <i>UCP3</i> Polymorphisms with Nonalcoholic Steatohepatitis and Metabolic Syndrome in Nonalcoholic Fatty Liver Disease Brazilian Patients

    METABOLIC SYNDROME AND RELATED DISORDERS, v.20, n.2, p.114-123, 2022

    Background: We investigated the possible association of uncoupling protein 3 gene (UCP3) single nucleotide polymorphisms (SNPs) with nonalcoholic steatohepatitis (NASH) and metabolic syndrome (MetS) in nonalcoholic fatty liver disease (NAFLD) Brazilian patients.Methods: UCP3 SNPs rs1726745, rs378...

  10. AFP score and metroticket 2.0 perform similarly and could be used in a ""within-ALL"" clinical decision tool

    JHEP REPORTS, v.5, n.2, article ID 100644, 10p, 2023

    Background & Aims: Two recently developed composite models, the alpha-fetoprotein (AFP) score and Metroticket 2.0, could be used to select patients with hepatocellular carcinoma (HCC) who are candidates for liver transplantation (LT). The aim of this study was to compare the predictive performanc...