LIM/22 - Laboratório de Patolologia Cardiovascular
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Asthma in Brazil: an epidemiological analysis from 2008 to 2021
EUROPEAN RESPIRATORY JOURNAL, v.62, suppl.67, article ID PA3405, 3p, 2023
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Advances in diffuse glial tumors diagnosis
ARQUIVOS DE NEURO-PSIQUIATRIA, v.81, n.12, p.1134-1145, 2023
In recent decades, there have been significant advances in the diagnosis of diffuse gliomas, driven by the integration of novel technologies. These advancements have deepened our understanding of tumor oncogenesis, enabling a more refined stratification of the biological behavior of these neoplas...
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Malignant neoplasm of breast in Brazilian women: A cross-sectional study from 2008 to 2019
JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION, v.115, n.1, p.38-45, 2023
Objective: Breast cancer is the most lethal malignancy for women worldwide. Developed countries, such as Portugal, Spain, and the United States, have declining mortality rates due to breast cancer; however, in developing countries, the epidemiological reports are scarce. In this context, the aims...
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Priorities for research on neuromodulatory subcortical systems in Alzheimer's disease: Position paper from the NSS PIA of ISTAART
ALZHEIMERS & DEMENTIA, v.19, n.5, p.2182-2196, 2023
The neuromodulatory subcortical system (NSS) nuclei are critical hubs for survival, hedonic tone, and homeostasis. Tau-associated NSS degeneration occurs early in Alzheimer's disease (AD) pathogenesis, long before the emergence of pathognomonic memory dysfunction and cortical lesions. Accumulatin...
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Neuronal and glial vulnerability of the suprachiasmatic nucleus in tauopathies: evidence from human studies and animal models
MOLECULAR NEURODEGENERATION, v.19, n.1, article ID 4, 16p, 2024
Tauopathies, a group of neurodegenerative diseases that includes Alzheimer's disease, commonly lead to disturbances in sleep-wake patterns and circadian rhythm disorders. The circadian rhythm, a recurring 24-hour cycle governing human biological activity, is regulated by the hypothalamic suprachi...
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Association between APOE-ε4 allele and cognitive function is mediated by Alzheimer's disease pathology: a population-based autopsy study in an admixed sample
ACTA NEUROPATHOLOGICA COMMUNICATIONS, v.11, n.1, article ID 205, 10p, 2023
Background: Apolipoprotein E epsilon 4 allele (APOE-epsilon 4) is the main genetic risk factor for late-onset Alzheimer's disease (AD) and may impact cognitive function also via other neuropathological lesions. However, there is limited evidence available from diverse populations, as APOE associa...
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Aren't you forgetting something? Cognitive screening beyond delirium in the emergency department
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, v.71, n.3, p.987-991, 2023
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Untangle the relationship of muscle mass and bone mineral content on handgrip strength: Results of ELSA-Brasil
CIENCIA & SAUDE COLETIVA, v.28, n.11, p.3191-3204, 2023
The study aims to investigate the independent association of muscle mass (MM) and bone mineral content (BMC) in the performance of the handgrip strength (HGS) test and whether there is effect modification by sex and age. In 12,491 participants from the ELSA-Brasil we estimated the associations be...
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Clinical characteristics and outcomes of COVID-19 patients with preexisting dementia: a large multicenter propensity-matched Brazilian cohort study
BMC GERIATRICS, v.24, n.1, article ID 25, 11p, 2024
Background Although dementia has emerged as an important risk factor for severe SARS-CoV-2 infection, results on COVID-19-related complications and mortality are not consistent. We examined the clinical presentations and outcomes of COVID-19 in a multicentre cohort of in-hospital patients, compar...
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Risk factors for dementia in Brazil: Differences by region and race
ALZHEIMERS & DEMENTIA, v.19, n.5, p.1849-1857, 2023
Introduction Twelve risk factors (RFs) account for 40% of dementia cases worldwide. However, most data for population attributable fractions (PAFs) are from high-income countries (HIC). We estimated how much these RFs account for dementia cases in Brazil, stratifying estimates by race and socioec...
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