LIM/24 - Centro de Investigação Translacional em Oncologia

O Centro de Investigação Translacional em Oncologia é ligado ao Departamento de Radiologia e Oncologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: marcadores moleculares em câncer; bases moleculares de tumorigênese, com ênfase em câncer de mama, hepatocarcionoma e melanoma; papel funcional de genes regulados por hormônios esteroides e por vitamina D em câncer de mama; marcadores preditivos à resposta a quimioterapia em câncer de mama, câncer de cabeça e pescoço e melanoma; mecanismos moleculares de quimiossensibilização e quimiorresistência; microRNAs na progressão de câncer de mama; interações celulares no microambiente tumoral como alvo terapêutico; terapias moleculares alvo-dirigidas em oncologia clínica.

Site oficial:http://limhc.fm.usp.br/portal/lim24-centro-de-investigacao-translacional-em-oncologia/

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Recent Submissions

  1. Data-driven, cross-disciplinary collaboration: lessons learned at the largest academic health center in Latin America during the COVID-19 pandemic

    FRONTIERS IN PUBLIC HEALTH, v.12, article ID 1369129, 15p, 2024

    Introduction The COVID-19 pandemic has prompted global research efforts to reduce infection impact, highlighting the potential of cross-disciplinary collaboration to enhance research quality and efficiency.Methods At the FMUSP-HC academic health system, we implemented innovative flow management r...

  2. Frequency of Human Papillomavirus Detection in Chagasic Megaesophagus Associated or Not with Esophageal Squamous Cell Carcinoma

    PATHOBIOLOGY, v.89, n.1, p.29-37, 2022

    Background: Chagasic megaesophagus (CM) as well as the presence of human papillomavirus (HPV) has been reported as etiological factors for esophageal squamous cell carcinoma (ESCC). Objective: We assessed the prevalence of HPV DNA in a series of ESCCs associated or not with CM. Data obtained were...

  3. Locking and Unlocking Thrombin Function Using Immunoquiescent Nucleic Acid Nanoparticles with Regulated Retention In Vivo

    NANO LETTERS, v.22, n.14, p.5961-5972, 2022

    The unbalanced coagulation of blood is a life-threatening event that requires accurate and timely treatment. We introduce a user-friendly biomolecular platform based on modular RNA-DNA anticoagulant fibers programmed for reversible extracellular communication with thrombin and subsequent control ...

  4. Protein Disulfide Isomerase overexpression induces mitochondrial reorganization and a differentiated VSMC phenotype: role of mitofusin-2

    FREE RADICAL BIOLOGY AND MEDICINE, v.208, suppl.1, p.S98-S98, 2023

  5. Five-Year Survival in Patients with ES-SCLC Treated with Atezolizumab in IMpower133: Imbrella a Extension Study Results

    JOURNAL OF THORACIC ONCOLOGY, v.18, n.11, suppl.S, p.S44-S45, 2023

  6. Canakinumab with Standard of Care for Patients with Advanced NSCLC: T-cell Infiltration Analysis in CANOPY-1

    JOURNAL OF THORACIC ONCOLOGY, v.18, n.11, suppl.S, p.S313-S313, 2023

  7. AVANZAR: Phase III Study of Datopotamab Deruxtecan (Dato-DXd) plus Durvalumab plus Carboplatin as 1L Treatment of Advanced/mNSCLC

    JOURNAL OF THORACIC ONCOLOGY, v.18, n.11, suppl.S, p.S305-S306, 2023

  8. A Phase II Trial of JDQ443 in <i>KRAS G12C</i>-Mutated NSCLC with PD-L1 Expression &lt;1% or PD-L1 Expression ≥1% and an <i>STK11</i> Co-Mutation

    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, v.118, n.1, p.E13-E14, 2024

  9. Real-world clinical characteristics and treatment (tx) outcomes by co-mutation status in patients (pts) with <i>KRAS G12C</i>- mutated non-small cell lung cancer (NSCLC)

    CANCER RESEARCH, v.83, n.7, suppl.S, 2023

  10. Sympathetic Neural Overdrive, Endothelial Dysfunction and Aortic Stiffness in Coronavirus Disease 2019 Survivors: A Short-Term Study of Cardiovascular Sequelae

    CIRCULATION, v.144, suppl.1, 2021