LIM/27 - Laboratório de Neurociências
URI Permanente desta comunidade
O Laboratório de Neurociências é ligado ao Departamento de Neurologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP).
Linhas de pesquisa: expressão gênica em amostras cerebrais e outros tecidos derivados de pacientes com doenças neuropsiquiátricas; farmacogenética; biologia celular e culturas primárias de neurônios; ressonância magnética e espectroscopia; metabolismo de fosfolípedes na membrana neuronal; estudos clínico-epidemiológicos e ensaios farmacêuticos; biomarcadores moleculares em doenças neuropsiquiátricas; lítio e neuroproteção na doença de Alzheimer, modelos animais em doenças neuropsiquiátricas.
Site oficial: http://limhc.fm.usp.br/portal/lim27-laboratorio-de-neurociencias/
Linhas de pesquisa: expressão gênica em amostras cerebrais e outros tecidos derivados de pacientes com doenças neuropsiquiátricas; farmacogenética; biologia celular e culturas primárias de neurônios; ressonância magnética e espectroscopia; metabolismo de fosfolípedes na membrana neuronal; estudos clínico-epidemiológicos e ensaios farmacêuticos; biomarcadores moleculares em doenças neuropsiquiátricas; lítio e neuroproteção na doença de Alzheimer, modelos animais em doenças neuropsiquiátricas.
Site oficial: http://limhc.fm.usp.br/portal/lim27-laboratorio-de-neurociencias/
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Coleções desta Comunidade
- LIM/27 - Laboratório de Neurociências
- LIM/27 - Laboratório de Neurociências
- LIM/27 - Laboratório de Neurociências
Submissões Recentes
New treatment strategies for mental health
(2023) HASHIMOTO, Kenji; SCHMITT, Andrea
Disturbed Oligodendroglial Maturation Causes Cognitive Dysfunction in Schizophrenia: A New Hypothesis
(2023) FALKAI, Peter; ROSSNER, Moritz J.; RAABE, Florian J.; WAGNER, Elias; KEESER, Daniel; MAURUS, Isabel; ROELL, Lukas; CHANG, Emily; SEITZ-HOLLAND, Johanna; SCHULZE, Thomas G.; SCHMITT, Andrea
Background and Hypothesis Cognitive impairment is a hallmark of schizophrenia, but no effective treatment is available to date. The underlying pathophysiology includes disconnectivity between hippocampal and prefrontal brain regions. Supporting evidence comes from diffusion-weighted imaging studies that suggest abnormal organization of frontotemporal white matter pathways in schizophrenia. Study Design Here, we hypothesize that in schizophrenia, deficient maturation of oligodendrocyte precursor cells (OPCs) into mature oligodendrocytes substantially contributes to abnormal frontotemporal macro- and micro-connectivity and subsequent cognitive deficits. Study Results Our postmortem studies indicate a reduced oligodendrocyte number in the cornu ammonis 4 (CA4) subregion of the hippocampus, and others have reported the same histopathological finding in the dorsolateral prefrontal cortex. Our series of studies on aerobic exercise training showed a volume increase in the hippocampus, specifically in the CA4 region, and improved cognition in individuals with schizophrenia. The cognitive effects were subsequently confirmed by meta-analyses. Cell-specific schizophrenia polygenic risk scores showed that exercise-induced CA4 volume increase significantly correlates with OPCs. From animal models, it is evident that early life stress and oligodendrocyte-related gene variants lead to schizophrenia-related behavior, cognitive deficits, impaired oligodendrocyte maturation, and reduced myelin thickness. Conclusions Based on these findings, we propose that pro-myelinating drugs (e.g., the histamine blocker clemastine) combined with aerobic exercise training may foster the regeneration of myelin plasticity as a basis for restoring frontotemporal connectivity and cognition in schizophrenia.
Cellular pathology in the limbic system in schizophrenia
(2023) SCHMITT, Andrea; FALKAI, Peter
Data-driven, cross-disciplinary collaboration: lessons learned at the largest academic health center in Latin America during the COVID-19 pandemic
(2024) RITTO, Ana Paula; ARAUJO, Adriana Ladeira de; CARVALHO, Carlos Roberto Ribeiro de; SOUZA, Heraldo Possolo De; FAVARETTO, Patricia Manga e Silva; SABOYA, Vivian Renata Boldrim; GARCIA, Michelle Louvaes; KULIKOWSKI, Leslie Domenici; KALLAS, Esper Georges; PEREIRA, Antonio Jose Rodrigues; COBELLO JUNIOR, Vilson; SILVA, Katia Regina; ABDALLA, Eidi Raquel Franco; SEGURADO, Aluisio Augusto Cotrim; SABINO, Ester Cerdeira; RIBEIRO JUNIOR, Ulysses; FRANCISCO, Rossana Pulcineli Vieira; MIETHKE-MORAIS, Anna; LEVIN, Anna Sara Shafferman; SAWAMURA, Marcio Valente Yamada; FERREIRA, Juliana Carvalho; SILVA, Clovis Artur; MAUAD, Thais; GOUVEIA, Nelson da Cruz; LETAIF, Leila Suemi Harima; BEGO, Marco Antonio; BATTISTELLA, Linamara Rizzo; DUARTE, Alberto Jose da Silva; SEELAENDER, Marilia Cerqueira Leite; MARCHINI, Julio; FORLENZA, Orestes Vicente; ROCHA, Vanderson Geraldo; MENDES-CORREA, Maria Cassia; COSTA, Silvia Figueiredo; CERRI, Giovanni Guido; BONFA, Eloisa Silva Dutra de Oliveira; CHAMMAS, Roger; BARROS FILHO, Tarcisio Eloy Pessoa de; BUSATTO FILHO, Geraldo
Introduction The COVID-19 pandemic has prompted global research efforts to reduce infection impact, highlighting the potential of cross-disciplinary collaboration to enhance research quality and efficiency.Methods At the FMUSP-HC academic health system, we implemented innovative flow management routines for collecting, organizing and analyzing demographic data, COVID-related data and biological materials from over 4,500 patients with confirmed SARS-CoV-2 infection hospitalized from 2020 to 2022. This strategy was mainly planned in three areas: organizing a database with data from the hospitalizations; setting-up a multidisciplinary taskforce to conduct follow-up assessments after discharge; and organizing a biobank. Additionally, a COVID-19 curated collection was created within the institutional digital library of academic papers to map the research output.Results Over the course of the experience, the possible benefits and challenges of this type of research support approach were identified and discussed, leading to a set of recommended strategies to enhance collaboration within the research institution. Demographic and clinical data from COVID-19 hospitalizations were compiled in a database including adults and a minority of children and adolescents with laboratory confirmed COVID-19, covering 2020-2022, with approximately 350 fields per patient. To date, this database has been used in 16 published studies. Additionally, we assessed 700 adults 6 to 11 months after hospitalization through comprehensive, multidisciplinary in-person evaluations; this database, comprising around 2000 fields per subject, was used in 15 publications. Furthermore, thousands of blood samples collected during the acute phase and follow-up assessments remain stored for future investigations. To date, more than 3,700 aliquots have been used in ongoing research investigating various aspects of COVID-19. Lastly, the mapping of the overall research output revealed that between 2020 and 2022 our academic system produced 1,394 scientific articles on COVID-19.Discussion Research is a crucial component of an effective epidemic response, and the preparation process should include a well-defined plan for organizing and sharing resources. The initiatives described in the present paper were successful in our aim to foster large-scale research in our institution. Although a single model may not be appropriate for all contexts, cross-disciplinary collaboration and open data sharing should make health research systems more efficient to generate the best evidence.
Employment, education, and clinical characteristics in older-age bipolar disorder: Analysis from the GAGE-BD database project
(2023) MALLU, Amulya; CHAN, Carol; EYLER, Lisa; DOLS, Annemiek; REJ, Soham; BLUMBERG, Hilary; SARNA, Kaylee; BRIGGS, Farren; FORESTER, Brent; PATRICK, Regan; FORLENZA, Orestes; JIMENEZ, Esther; VIETA, Eduard; SCHOUWS, Sigfried; PAANS, Nadine; SUTHERLAND, Ashley; YALA, Joy; SAJATOVIC, Martha