Rethinking the multiple roles of B cells in organ transplantation

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art_COELHO_Rethinking_the_multiple_roles_of_B_cells_in_2013.PDF (283.88 KB)
Citações na Scopus
19
Tipo de produção
article
Data de publicação
2013
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
LIPPINCOTT WILLIAMS & WILKINS
Autores
SAITOVITCH, David
Citação
CURRENT OPINION IN ORGAN TRANSPLANTATION, v.18, n.1, p.13-21, 2013
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Purpose of review To discuss the B-cell diverse functions in organ transplantation, highlighting the emerging debate on the role of regulatory B cells (Bregs). We underscore the need to re-examine and integrate data on B-cell functional activities, aiming to discriminate their regulatory (REG) and inflammatory (INFLAMMA) functions and to translate this knowledge for the development of novel immunomodulatory therapeutic strategies and to rethink the current ones. Recent findings Data from both experimental models and clinical trials point that B cells of various phenotypes have immunoregulatory activity and play an important role in controlling graft inflammation. Data on the state of operational tolerance, in kidney transplantation, suggest the relevance of preserving a healthy B-cell compartment - in numbers and in the Breg capacity to activate the CD40/STAT3 signalling pathway - for achieving and maintaining homeostasis. Moreover, autoantibodies also comprise transplant immunobiology and it seems that not all alloantibodies are deleterious. Summary The role of B cells, in organ transplantation, can no longer be taken as mere generators of plasma cells, which produce alloantibodies deleterious to the graft. B cells also seem to integrate a complex immunoregulatory network in organ transplantation, with Bregs of various phenotypes and possibly also antibodies. The functional discrimination of REG/INFLAMMA B-cell roles needs to be considered in the clinical setting.
Palavras-chave
alloantibodies, autoantibodies, B cells, regulatory B cells, reshaping the B-cell compartment, transplantation tolerance
URI
https://observatorio.fm.usp.br/handle/OPI/3927
Referências
  1. Adis R&D Profile, 2010, DRUGS R D, V10, P55
  2. Ashton-Chess J, 2009, TRANSPLANTATION, V87, pS95, DOI 10.1097/TP.0b013e3181a2e295
  3. Azimzadeh AM, 2005, AM J TRANSPLANT, V5, P2349, DOI 10.1111/j.1600-6143.2005.01022.x
  4. Battaglia M, 2006, J IMMUNOL, V177, P8338
  5. Becker YT, 2006, TRANSPLANT INT, V19, P621, DOI 10.1111/j.1432-2277.2006.00345.x
  6. Blair PA, 2010, IMMUNITY, V32, P129, DOI 10.1016/j.immuni.2009.11.009
  7. Bloom D, 2009, AM J TRANSPLANT, V9, P1835, DOI 10.1111/j.1600-6143.2009.02710.x
  8. Brouard S, 2007, P NATL ACAD SCI USA, V104, P15448, DOI 10.1073/pnas.0705834104
  9. Buggins AGS, 2002, BLOOD, V100, P1715
  10. Calne R, 1998, LANCET, V351, P1701, DOI 10.1016/S0140-6736(05)77739-4
  11. Calne R, 1999, TRANSPLANTATION, V68, P1613, DOI 10.1097/00007890-199911270-00032
  12. Cherukuri A, 2012, AM J TRANSPLANT, V12, P919, DOI 10.1111/j.1600-6143.2011.03891.x
  13. Chong AS, 2011, AM J TRANSPLANT, V11, P2555, DOI 10.1111/j.1600-6143.2011.03773.x
  14. Clatworthy MR, 2009, NEW ENGL J MED, V360, P2683, DOI 10.1056/NEJMc0808481
  15. Clatworthy MR, 2011, AM J TRANSPLANT, V11, P1359, DOI 10.1111/j.1600-6143.2011.03554.x
  16. Cobbold S, 1998, CURR OPIN IMMUNOL, V10, P518, DOI 10.1016/S0952-7915(98)80217-3
  17. Cohen IR, 2007, NAT REV IMMUNOL, V7, P569, DOI 10.1038/nri2102
  18. Cohen IR, 2007, J AUTOIMMUN, V29, P246, DOI 10.1016/j.jaut.2007.07.016
  19. Crawford A, 2006, J IMMUNOL, V176, P3498
  20. Danger R, 2012, J AM SOC NEPHROL, V23, P597, DOI 10.1681/ASN.2011060543
  21. DiLillo DJ, 2011, J IMMUNOL, V186, P2643, DOI 10.4049/jimmunol.1002983
  22. Ding Q, 2011, J CLIN INVEST, V121, P3645, DOI 10.1172/JCI46274
  23. Dragun D, 2005, NEW ENGL J MED, V352, P558, DOI 10.1056/NEJMoa035717
  24. Dunn TB, 2011, AM J TRANSPLANT, V11, P2132, DOI 10.1111/j.1600-6143.2011.03640.x
  25. Everly MJ, 2008, TRANSPLANTATION, V86, P1754, DOI 10.1097/TP.0b013e318190af83
  26. Fehr T, 2009, TRANSPLANTATION, V87, P1837, DOI 10.1097/TP.0b013e3181a6bac5
  27. Fillatreau S, 2002, NAT IMMUNOL, V3, P944, DOI 10.1038/ni833
  28. Gasser M, 2002, TRANSPLANT P, V34, P2244, DOI 10.1016/S0041-1345(02)03221-9
  29. Goers TA, 2008, J IMMUNOL, V180, P4487
  30. Graff RJ, 2009, HUM IMMUNOL, V70, P502, DOI 10.1016/j.humimm.2009.04.002
  31. Guo HL, 2010, NATURE, V466, P835, DOI 10.1038/nature09267
  32. Hagedorn PH, 2010, IMMUNOLOGY, V130, P427, DOI 10.1111/j.1365-2567.2010.03246.x
  33. Hale G, 1983, Mol Biol Med, V1, P321
  34. HALE G, 1990, TISSUE ANTIGENS, V35, P118, DOI 10.1111/j.1399-0039.1990.tb01767.x
  35. Hanaway MJ, 2011, NEW ENGL J MED, V364, P1909, DOI 10.1056/NEJMoa1009546
  36. Harris DP, 2005, J IMMUNOL, V174, P6781
  37. Harris DP, 2000, NAT IMMUNOL, V1, P475, DOI 10.1038/82717
  38. Hashimoto Y, 2002, BLOOD, V100, P3504, DOI 10.1182/blood-2002-03-0733
  39. Heidt S, 2012, AM J TRANSPLANT, V12, P1784, DOI 10.1111/j.1600-6143.2012.04012.x
  40. Iwata T, 2008, J IMMUNOL, V181, P5738
  41. Iwata Y, 2011, BLOOD, V117, P530, DOI 10.1182/blood-2010-07-294249
  42. Jindra PT, 2006, TRANSPLANTATION, V82, pS33, DOI 10.1097/01.tp.0000231447.34240.3c
  43. Jonker M, 2005, TRANSPLANTATION, V80, P385, DOI 10.1097/01.tp.0000166920.18998.15
  44. Kamburova EG, 2012, AM J TRANSPLANT, V12, P341, DOI 10.1111/j.1600-6143.2011.03833.x
  45. Kaneku H, 2012, LIVER TRANSPLANT, V18, P984, DOI 10.1002/lt.23451
  46. Kokko KE, 2012, AM J TRANSPLANT, V12, P1077, DOI 10.1111/j.1600-6143.2012.04016.x
  47. Kweon MN, 1998, J IMMUNOL, V160, P1687
  48. Kwun J, 2012, SEMIN IMMUNOL, V24, P96, DOI 10.1016/j.smim.2011.08.022
  49. LaMattina JC, 2012, TRANSPL INT, V25, P518, DOI 10.1111/j.1432-2277.2012.01448.x
  50. Lechler R, 2001, IMMUNITY, V14, P357, DOI 10.1016/S1074-7613(01)00116-9
  51. Le Texier L, 2011, AM J TRANSPLANT, V11, P429, DOI 10.1111/j.1600-6143.2010.03336.x
  52. Linton PJ, 2000, J IMMUNOL, V165, P5558
  53. Lund FE, 2010, NAT REV IMMUNOL, V10, P236, DOI 10.1038/nri2729
  54. Mackay F, 2002, NAT REV IMMUNOL, V2, P465, DOI 10.1038/nri844
  55. Mackay F, 2009, NAT REV IMMUNOL, V9, P491, DOI 10.1038/nri2572
  56. Mackay F, 2003, ANNU REV IMMUNOL, V21, P231, DOI 10.1146/annurev.immunol.21.120601.141152
  57. Mann MK, 2007, J IMMUNOL, V178, P3447
  58. Mauri C, 2003, J EXP MED, V197, P489, DOI 10.1084/jem.20021293
  59. Mauri C, 2012, ANNU REV IMMUNOL, V30, P221, DOI 10.1146/annurev-immunol-020711-074934
  60. Mauri C, 2010, NAT REV RHEUMATOL, V6, P636, DOI 10.1038/nrrheum.2010.140
  61. Meister S, 2007, CANCER RES, V67, P1783, DOI 10.1158/0008-5472.CAN-06-2258
  62. Merbl Y, 2007, J CLIN INVEST, V117, P712, DOI 10.1072/JC129943
  63. Mizoguchi A, 2006, J IMMUNOL, V176, P705
  64. Mizoguchi A, 2002, IMMUNITY, V16, P219, DOI 10.1016/S1074-7613(02)00274-1
  65. Moraes-Vieira PMM, 2010, HUM IMMUNOL, V71, P442, DOI 10.1016/j.humimm.2010.01.022
  66. Moraes-Vieira PMM, 2012, CLIN IMMUNOL, V142, P117, DOI 10.1016/j.clim.2011.08.015
  67. Nath DS, 2011, TRANSPLANTATION, V91, P1036, DOI 10.1097/TP.0b013e318211d2f4
  68. Newell KA, 2010, J CLIN INVEST, V120, P1836, DOI 10.1172/JCI39933
  69. Newell KA, 2011, CURR OPIN IMMUNOL, V23, P655, DOI 10.1016/j.coi.2011.07.008
  70. Noorchashm H, 2006, J IMMUNOL, V177, P7715
  71. Obeng EA, 2006, BLOOD, V107, P4907, DOI 10.1182/blood-2005-08-3531
  72. Olofsson PS, 2012, IMMUNOL REV, V248, P188, DOI 10.1111/j.1600-065X.2012.01138.x
  73. Otto C, 2001, TRANSPLANT P, V33, P431, DOI 10.1016/S0041-1345(00)02079-0
  74. Pallier A, 2010, KIDNEY INT, V78, P503, DOI 10.1038/ki.2010.162
  75. Parsons RF, 2012, TRANSPLANTATION, V93, P676, DOI 10.1097/TP.0b013e318246621d
  76. PIERCE SK, 1988, IMMUNOL REV, V106, P149, DOI 10.1111/j.1600-065X.1988.tb00778.x
  77. Porcheray F, 2010, TRANSPLANTATION, V89, P1239, DOI 10.1097/TP.0b013e3181d72091
  78. Portugal K, 2001, INT IMMUNOL, V13, P747, DOI 10.1093/intimm/13.6.747
  79. Qin ZQ, 2011, TRANSPLANTATION, V92, P829, DOI 10.1097/TP.0b013e31822d0977
  80. Quintana FJ, 2006, LUPUS, V15, P428, DOI 10.1191/0961203306lu2328oa
  81. Redfield RR, 2011, CURR OPIN IMMUNOL, V23, P685, DOI 10.1016/j.coi.2011.07.011
  82. Riewaldt Julia, 2012, Front Immunol, V3, P141, DOI 10.3389/fimmu.2012.00141
  83. Rogers NJ, 2001, AM J TRANSPLANT, V1, P97, DOI 10.1034/j.1600-6143.2001.10201.x
  84. Rowe V, 2006, BLOOD, V108, P2485, DOI 10.1182/blood-2006-04-016063
  85. Sagoo P, 2010, J CLIN INVEST, V120, P1848, DOI 10.1172/JCI39922
  86. Silva HM, 2012, MOL MED, V18, P733, DOI 10.2119/molmed.2011.00281
  87. Spadafora-Ferreira M, 2007, SCAND J IMMUNOL, V66, P352, DOI 10.1111/j.1365-3083.2007.01976.x
  88. Stastny P, 2009, HUM IMMUNOL, V70, P600, DOI 10.1016/j.humimm.2009.04.017
  89. Sun QQ, 2005, TRANSPLANTATION, V79, P1759, DOI 10.1097/01.TP.0000163290.19788.E7
  90. Sun QQ, 2011, KIDNEY INT, V79, P655, DOI 10.1038/ki.2010.437
  91. Sun QQ, 2008, CLIN J AM SOC NEPHRO, V3, P1479, DOI 10.2215/CJN.04451007
  92. SWAIN SL, 1987, IMMUNOL REV, V99, P263, DOI 10.1111/j.1600-065X.1987.tb01180.x
  93. Thaunat O, 2011, TRANSPLANTATION, V92, P121, DOI 10.1097/TP.0b013e31821f74fe
  94. Thaunat O, 2012, KIDNEY INT, V81, P207, DOI 10.1038/ki.2011.317
  95. Thaunat O, 2010, J IMMUNOL, V185, P717, DOI 10.4049/jimmunol.0903589
  96. Thibault-Espitia A, 2012, AM J TRANSPLANT, V12, P2754, DOI 10.1111/j.1600-6143.2012.04194.x
  97. Thiyagarajan UM, 2012, TRANSPL P, V44, P1231, DOI 10.1016/j.transproceed.2011.10.054
  98. Trivedi HL, 2009, TRANSPLANTATION, V87, P1555, DOI 10.1097/TP.0b013e3181a4b91b
  99. Tsang JYS, 2009, TRANSPL IMMUNOL, V21, P203, DOI 10.1016/j.trim.2009.05.003
  100. Tsang JYS, 2008, J CLIN INVEST, V118, P3619, DOI 10.1172/JCI33185
  101. Tyden G, 2009, TRANSPLANTATION, V87, P1325, DOI 10.1097/TP.0b013e3181a235fd
  102. UCKUN FM, 1990, BLOOD, V76, P1908
  103. Venetz JP, 2007, EXPERT OPIN INV DRUG, V16, P625, DOI 10.1517/13543784.16.5.625
  104. Waldmann H, 2006, IMMUNOL REV, V212, P301, DOI 10.1111/j.0105-2896.2006.00406.x
  105. Walsh RC, 2010, TRANSPLANTATION, V89, P277, DOI 10.1097/TP.0b013e3181c6ff8d
  106. Walsh RC, 2012, KIDNEY INT, V81, P1067, DOI 10.1038/ki.2011.502
  107. Walters S, 2009, J IMMUNOL, V182, P793
  108. Wiebe C, 2012, AM J TRANSPLANT, V12, P1157, DOI 10.1111/j.1600-6143.2012.04013.x
  109. Wilkes DS, 2012, SEMIN IMMUNOL, V24, P131, DOI 10.1016/j.smim.2011.08.020
  110. Wolf SD, 1996, J EXP MED, V184, P2271, DOI 10.1084/jem.184.6.2271
  111. Morrow WR, 2012, TRANSPLANTATION, V93, P319, DOI 10.1097/TP.0b013e31823f7eea
  112. Yanaba K, 2008, IMMUNITY, V28, P639, DOI 10.1016/j.immuni.2008.03.017
  113. Zarkhin V, 2010, TRANSPLANT REV-ORLAN, V24, P67, DOI 10.1016/j.trre.2010.01.004
  114. Zhou L, 2009, IMMUNITY, V30, P646, DOI 10.1016/j.immuni.2009.05.001

Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/19