Higher volumes of hippocampal subfields in pediatric obsessive-compulsive disorder
Carregando...
Citações na Scopus
6
Tipo de produção
article
Data de publicação
2021
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER IRELAND LTD
Citação
PSYCHIATRY RESEARCH-NEUROIMAGING, v.307, article ID 111200, 9p, 2021
Resumo
Differences in hippocampus volume have been identified in adult patients with obsessive-compulsive disorder (OCD). However, the role of this limbic structure in pediatric patients is unclear. This study aimed to investigate the hippocampus and its subregions in a sample of 29 children and adolescents with OCD compared to 28 healthy controls, matched for age, sex, education, and IQ. Volumetric segmentation was performed using the Freesurfer software to calculate the volumes of the subregions that reflect the hippocampal cytoarchitecture. The volumes of three anatomic subregions (tail, body, and head) were also calculated. ANCOVA was performed to investigate differences of these volumes between patients and controls, controlling for total gray matter volume. After Bonferroni correction for multiple comparisons (p-value < 0.00556 for the body and < 0.00625 for the head structures), patients presented statistically significant larger volumes of the following structures: left subiculum body; left CA4 body; left GC-DG body; left molecular layer body; right parasubiculum; left CA4 head; left molecular layer head; right subiculum head and right molecular layer head. These enlarged volumes resulted in larger left and right whole hippocampi in patients, as well as bilateral hippocampal heads and left hippocampal body (all p-values < 0.00625). There were no associations between OCD severity and hippocampal volumes. These findings diverge from previous reports on adults and may indicate that larger hippocampal volumes could reflect an early marker of OCD, not present in adults.
Palavras-chave
Pediatric obsessive-compulsive disorder, Hippocampus volume, Hippocampal subregions, Children, Youth
Referências
- Aggleton JP, 2015, PROG BRAIN RES, V219, P65, DOI 10.1016/bs.pbr.2015.03.003
- Ahmed-Leitao F, 2019, PSYCHIAT RES-NEUROIM, V284, P45, DOI 10.1016/j.pscychresns.2018.12.015
- Al-Amin M, 2018, BRAIN RES, V1685, P1, DOI 10.1016/j.brainres.2018.02.007
- American Psychiatric Association, 2013, DIAGN STAT MAN MENT, V17, P133, DOI 10.1176/APPI.BOOKS.9780890425596
- Atmaca M, 2008, PROG NEURO-PSYCHOPH, V32, P1283, DOI 10.1016/j.pnpbp.2008.04.002
- Atmaca M, 2009, PSYCHIAT CLIN NEUROS, V63, P486, DOI 10.1111/j.1440-1819.2009.01993.x
- Bartos A, 2019, PSYCHIAT RES-NEUROIM, V287, P70, DOI 10.1016/j.pscychresns.2019.01.014
- Birmaher B, 1997, J AM ACAD CHILD PSY, V36, P545, DOI 10.1097/00004583-199704000-00018
- Boedhoe PSW, 2017, AM J PSYCHIAT, V174, P60, DOI 10.1176/appi.ajp.2016.16020201
- Burgund ED, 2002, NEUROIMAGE, V17, P184, DOI 10.1006/nimg.2002.1174
- D'Alonzo KT, 2004, WESTERN J NURS RES, V26, P804, DOI 10.1177/0193945904266733
- Dalton MA, 2017, CURR OPIN BEHAV SCI, V17, P34, DOI 10.1016/j.cobeha.2017.06.001
- Dennis CV, 2016, NEUROPATH APPL NEURO, V42, P621, DOI 10.1111/nan.12337
- Duvernoy H.M., 2013, HUMAN HIPPOCAMPUS, P39
- Iglesias JE, 2015, NEUROIMAGE, V115, P117, DOI 10.1016/j.neuroimage.2015.04.042
- Fatori D, 2018, J ANXIETY DISORD, V58, P42, DOI 10.1016/j.janxdis.2018.07.002
- Fischl B, 2002, NEURON, V33, P341, DOI 10.1016/S0896-6273(02)00569-X
- Foo H, 2017, NEUROIMAGE-CLIN, V14, P37, DOI 10.1016/j.nicl.2016.12.008
- Fouche JP, 2017, BRIT J PSYCHIAT, V210, P67, DOI 10.1192/bjp.bp.115.164020
- GOODMAN WK, 1989, ARCH GEN PSYCHIAT, V46, P1006
- Gottwald J, 2018, PSYCHOL MED, V48, P1900, DOI 10.1017/S0033291717003464
- Grisham JR, 2009, BRIT J PSYCHIAT, V195, P138, DOI 10.1192/bjp.bp.108.056812
- Haukvik UK, 2018, J PSYCHIATR RES, V104, P217, DOI 10.1016/j.jpsychires.2018.08.012
- Heyman I, 2003, INT REV PSYCHIATR, V15, P178, DOI 10.1080/0954026021000046146
- Hong SB, 2007, EUR ARCH PSY CLIN N, V257, P185, DOI 10.1007/s00406-006-0655-5
- Kalra SK, 2009, J CLIN INVEST, V119, P737, DOI 10.1172/JCI37563
- Kaufman J, 1997, J AM ACAD CHILD PSY, V36, P980, DOI 10.1097/00004583-199707000-00021
- Konrad C, 2009, NEUROIMAGE, V47, P1185, DOI 10.1016/j.neuroimage.2009.05.019
- Koolschijn PCMP, 2013, EUR NEUROPSYCHOPHARM, V23, P622, DOI 10.1016/j.euroneuro.2012.07.001
- Lack CW, 2009, SOC PSYCH PSYCH EPID, V44, P935, DOI 10.1007/s00127-009-0013-9
- Lewin AB, 2014, PSYCHIAT RES, V216, P108, DOI 10.1016/j.psychres.2014.01.014
- MacMaster FP, 2004, BMC MED, V2, DOI 10.1186/1741-7015-2-2
- Menzies L, 2008, NEUROSCI BIOBEHAV R, V32, P525, DOI 10.1016/j.neubiorev.2007.09.005
- Milad MR, 2012, TRENDS COGN SCI, V16, P43, DOI 10.1016/j.tics.2011.11.003
- Nakatani E, 2011, J CHILD PSYCHOL PSYC, V52, P1261, DOI 10.1111/j.1469-7610.2011.02434.x
- Pauls DL, 2014, NAT REV NEUROSCI, V15, P410, DOI 10.1038/nrn3746
- Perez-Vigil A, 2018, JAMA PSYCHIAT, V75, P47, DOI 10.1001/jamapsychiatry.2017.3523
- Peter J, 2018, NEUROPSYCHOLOGIA, V109, P86, DOI 10.1016/j.neuropsychologia.2017.12.014
- Piacentini J, 2007, J CLIN CHILD ADOLESC, V36, P645, DOI 10.1080/15374410701662790
- Poppenk J, 2013, TRENDS COGN SCI, V17, P230, DOI 10.1016/j.tics.2013.03.005
- POZNANSKI EO, 1985, PSYCHOPHARMACOL BULL, V21, P979
- Rao S, 2018, J AFFECT DISORDERS, V236, P1, DOI 10.1016/j.jad.2018.04.048
- Rapoport JL, 2000, J ANXIETY DISORD, V14, P535, DOI 10.1016/S0887-6185(00)00048-7
- Reess TJ, 2018, NEUROIMAGE-CLIN, V17, P474, DOI 10.1016/j.nicl.2017.11.006
- Saygin ZM, 2017, NEUROIMAGE, V155, P370, DOI 10.1016/j.neuroimage.2017.04.046
- Stein DJ, 2019, NAT REV DIS PRIMERS, V5, DOI 10.1038/s41572-019-0102-3
- Taylor S, 2011, CLIN PSYCHOL REV, V31, P1083, DOI 10.1016/j.cpr.2011.06.007
- Taylor WD, 2014, AM J GERIAT PSYCHIAT, V22, P1504, DOI 10.1016/j.jagp.2013.11.004
- Thorsen AL, 2018, BIOL PSYCHIAT-COGN N, V3, P563, DOI 10.1016/j.bpsc.2018.01.009
- van den Heuvel OA, 2016, EUR NEUROPSYCHOPHARM, V26, P810, DOI 10.1016/j.euroneuro.2015.12.005
- Vattimo EFQ, 2019, EUR CHILD ADOLES PSY, V28, P1607, DOI 10.1007/s00787-019-01320-w
- Wechsler D., 1999, MANUAL WECHSLER ABBR
- Xu JA, 2010, NEUROIMAGE, V52, P1654, DOI 10.1016/j.neuroimage.2010.05.074
- Zhang LQ, 2019, HUM BRAIN MAPP, V40, P4105, DOI 10.1002/hbm.24688