Periodontal tissues are targets for Sars-Cov-2: a post-mortem study

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art_MATUCK_Periodontal_tissues_are_targets_for_SarsCov2_a_postmortem_2021.PDF (1.54 MB)
Citações na Scopus
63
Tipo de produção
article
Data de publicação
2021
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
TAYLOR & FRANCIS LTD
Autores
MATUCK, Bruno Fernandes
DOLHNIKOFF, Marisa
MAIA, Gilvan V. A.
SENDYK, Daniel Isaac
ZARPELLON, Amanda
GOMES, Sara Costa
DUARTE-NETO, Amaro Nunes
SOUSA, Suzana C. O. M.
Citação
JOURNAL OF ORAL MICROBIOLOGY, v.13, n.1, article ID 1848135, 6p, 2021
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background: The ability of coronavirus SARS-CoV-2 to spread is one of the determinants of the COVID-19 pandemic status. Until June 2020, global COVID-19 cases surpassed 10 million. Asymptomatic patients, with no respiratory impairment, are believed to be responsible for more than 80% of the transmission. Other viruses have been consistently detected in periodontal tissues. Objective: The aim of this study was to investigate the presence of SARS-CoV-2 in periodontal tissue. Methods: We conducted video-endoscope minimally invasive post-mortem biopsy in seven fatal cases of COVID-19, using a regular endoscope video system associated with a smartphone to locate periodontal tissue. We analyzed the samples using RT-PCR, to identify the SARS-CoV-2 RNA and histopathological analysis. Results: The seven studied autopsies with positive laboratory tests for COVID-19 included 57.14% of female patients at the average age of 47.4 (range 8 to 74). In five cases, periodontal tissue was positive for SARS-CoV-2 (RT-PCR). Histopathologic analyses showed morphologic alterations in the keratinocytes of the junctional epithelium, a vacuolization of the cytoplasm and nucleus and nuclear pleomorphism. Conclusion: We presented a biomolecular analysis obtained from minimally invasive autopsies. This is the first study to demonstrate the presence of SARS-CoV-2 in periodontal tissue in COVID-19 positive patients.
Palavras-chave
COVID-19, autopsy, infection control, oral manifestation, RT-PCR
URI
https://observatorio.fm.usp.br/handle/OPI/39376
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - COVID-19
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - IMT
Artigos e Materiais de Revistas Científicas - LIM/03
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