Impact of diabetes mellitus on arterial stiffness in a representative sample of an urban Brazilian population
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Citações na Scopus
41
Tipo de produção
article
Data de publicação
2013
Título da Revista
ISSN da Revista
Título do Volume
Editora
BIOMED CENTRAL LTD
Autores
MUSSO, Mariane Manso
CUNHA, Roberto de Sa
MILL, Jose Geraldo
Citação
DIABETOLOGY & METABOLIC SYNDROME, v.5, article ID 45, 8p, 2013
Resumo
Background: Independent of other cardiovascular (CV) risk factors, increased arterial stiffness has been established as a predictor of morbidity and mortality. The main aim of this study was to investigate the impact of diabetes on arterial stiffness in a representative sample of an urban Brazilian population plus Amerindians. Methods: A total of 1,415 individuals from the general population were randomly selected plus 588 Amerindians from a native community in Brazil. In addition, a sub-sample of 380 individuals from the general population had 5-year follow-up data. Pulse wave velocity (PWV) was measured with a non-invasive automatic device (Complior, Colson; Garges les Gonesses, France) and increased arterial stiffness was defined as PWV >= 12 m/s. Results: In the overall group, diabetic individuals had higher frequencies of increased arterial stiffness and hypertension. They also had higher values of PWV, body mass index, total cholesterol, triglycerides, systolic and diastolic blood pressures compared to non-diabetic individuals (p < 0.01). In an analysis stratified by hypertension, PWV values and increased arterial stiffness frequency were higher in diabetic individuals in both groups (hypertensive and non-hypertensive) (p < 0.05). Furthermore, higher risk for increased arterial stiffness was observed in the diabetic individuals from the overall group (OR = 2.27; CI = 1.47-3.52, p < 0.001) and from the hypertensive group (OR = 2.70; CI = 1.58-4.75, p < 0.001), adjusted for covariates. Regarding the ethnic stratification, diabetic individuals from Amerindian, White, and Mulatto (mixed-race) groups had higher PWV values and a greater frequency of increased arterial stiffness compared to non-diabetic individuals. Both diabetic and non-diabetic individuals had higher PWV values after 5 years. There was no significant difference in the 5-year PWV progression in diabetic compared to non-diabetic individuals. Conclusions: These results confirm, in a sample of Brazilian population, that the presence of diabetes is associated with increased arterial stiffness and it may contribute in part to increased cardiovascular risk in diabetic patients.
Palavras-chave
Arterial stiffness, Diabetes mellitus, Hypertension, Brazilian population
Referências
- Alvim RO, 2010, LIPIDS HEALTH DIS, V9, DOI 10.1186/1476-511X-9-128
- [Anonymous], 2001, JAMA, V285, P2486
- ARNETT DK, 1994, AM J EPIDEMIOL, V140, P669
- Aronson D, 2003, J HYPERTENS, V21, P3, DOI 10.1097/01.hjh.0000042892.24999.92
- ASMAR R, 1995, HYPERTENSION, V26, P485
- BURT VL, 1995, HYPERTENSION, V25, P305
- BURT VL, 1995, HYPERTENSION, V26, P60
- Cameron JD, 2007, CLIN EXP PHARMACOL P, V34, P677, DOI 10.1111/j.1440-1681.2007.04659.x
- Cardoso CRL, 2009, ATHEROSCLEROSIS, V205, P472, DOI 10.1016/j.atherosclerosis.2008.12.027
- Chen GM, 2011, HYPERTENSION, V57, P891, DOI 10.1161/HYPERTENSIONAHA.110.162446
- Chen YH, 2009, ENDOCRINE, V36, P262, DOI 10.1007/s12020-009-9221-z
- CORNONIHUNTLEY J, 1989, ARCH INTERN MED, V149, P780, DOI 10.1001/archinte.149.4.780
- Creager MA, 2003, CIRCULATION, V108, P1527, DOI 10.1161/01.CIR.0000091257.27563.32
- De Angelis L, 2004, HYPERTENSION, V44, P67, DOI 10.1161/01.HYP.0000130482.81883.fd
- Ferrannini E, 2012, LANCET, V380, P601, DOI 10.1016/S0140-6736(12)60987-8
- Ferreira AVL, 1999, J HYPERTENS, V17, P631, DOI 10.1097/00004872-199917050-00006
- Galler A, 2010, PEDIATR DIABETES, V11, P38, DOI 10.1111/j.1399-5448.2009.00525.x
- Guerin AP, 2001, CIRCULATION, V103, P987
- Haffner SM, 1998, NEW ENGL J MED, V339, P229, DOI 10.1056/NEJM199807233390404
- Laurent S, 2003, STROKE, V34, P1203, DOI 10.1161/01.STR.0000065428.03209.64
- Laurent S, 2001, HYPERTENSION, V37, P1236
- Lessa I, 1997, Arq Bras Cardiol, V68, P443
- Li CH, 2012, J CLIN ENDOCR METAB, V97, pE658, DOI 10.1210/jc.2011-2595
- Lukich E, 2010, DIABETES-METAB RES, V26, P365, DOI 10.1002/dmrr.1086
- Mancia G, 2007, J HYPERTENS, V25, P1105, DOI 10.1097/HJH.0b013e3281fc975a
- Mattace-Raso FUS, 2006, CIRCULATION, V113, P657, DOI 10.1161/CIRCULATIONAHA.105.555235
- Mazzone T, 2008, LANCET, V371, P1800, DOI 10.1016/S0140-6736(08)60768-0
- MCVEIGH GE, 1992, DIABETOLOGIA, V35, P771
- Meaume S, 2001, ARTERIOSCL THROM VAS, V21, P2046, DOI 10.1161/hq1201.100226
- Naka KK, 2012, CARDIOVASC DIABETOL, V11, DOI 10.1186/1475-2840-11-127
- Pereira AC, 2006, ATHEROSCLEROSIS, V184, P193, DOI 10.1016/j.atherosclerosis.2005.03.035
- Santos PCJL, 2012, LIPIDS HEALTH DIS, V11, DOI 10.1186/1476-511X-11-83
- Santos PCJD, 2011, AM J HYPERTENS, V24, P278, DOI 10.1038/ajh.2010.244
- Stehouwer CD, 2006, DIABETES LIPIDS OTHE
- Stehouwer CDA, 2008, DIABETOLOGIA, V51, P527, DOI 10.1007/s00125-007-0918-3
- Stewart AD, 2006, HYPERTENSION, V48, P404, DOI 10.1161/01.HYP.0000237669.64066.c5
- Strain WD, 2006, AM J HYPERTENS, V19, P889, DOI 10.1016/j.amjhyper.2006.01.009
- Sytkowski PA, 1996, CIRCULATION, V93, P697
- Tan KCB, 2002, DIABETES CARE, V25, P1055, DOI 10.2337/diacare.25.6.1055
- Tedesco MA, 2004, J HUM HYPERTENS, V18, P469, DOI 10.1038/sj.jhh.1001690
- TUNSTALLPEDOE H, 1994, CIRCULATION, V90, P583
- VAITKEVICIUS PV, 1993, CIRCULATION, V88, P1456
- Van Bortel LM, 2012, J HYPERTENS, V30, P445, DOI 10.1097/HJH.0b013e32834fa8b0
- Vlachopoulos C, 2010, J AM COLL CARDIOL, V55, P1318, DOI 10.1016/j.jacc.2009.10.061
- VYSSOULIS G, 2012, DIABETES VASC DIS RE, V9, P18, DOI 10.1177/1479164111422827
- Watts GF, 1996, CLIN SCI, V91, P567
- Whincup PH, 2005, CIRCULATION, V112, P1789, DOI 10.1161/CIRCULATIONHA.104.5632663
- Yue WS, 2011, CARDIOVASC DIABETOL, V10, DOI 10.1186/1475-2840-10-113
- Zoungas S, 2007, CLIN EXP PHARMACOL P, V34, P647, DOI 10.1111/j.1440-1681.2007.04654.x
- 1999, J HYPERTENS, V17, P151