Individual exposure to urban air pollution and its correlation with placental angiogenic markers in the first trimester of pregnancy, in Sao Paulo, Brazil
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Citações na Scopus
6
Tipo de produção
article
Data de publicação
2021
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER HEIDELBERG
Autores
HOSHIDA, Mara Sandra
SALDIVA, Silvia Regina Dias Medici
Citação
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, v.28, n.22, p.28658-28665, 2021
Resumo
Pollution of the atmosphere is known that may lead to adverse obstetric outcomes, including fetal growth restriction, gestational hypertension, and preeclampsia. Such disorders are correlated with imbalances in angiogenic factors, which may also be involved in the pathological mechanism as the pollutants impact placental and maternal physiology. In the first trimester of gestation, this study assessed the outcomes of personal maternal short period exposure to air pollution on soluble fms-like tyrosine kinase 1 (sFlt1) and placental growth factor (PLGF) of pregnant women blood concentrations. This was a cross-sectional study, held in the city of Sao Paulo, Brazil, and conducted with low-risk pregnant women, who carried personal passive nitrogen dioxide (NO2) and ozone (O-3) monitors for about a few days preceding the ultrasound evaluation, and on this day, the venous blood sample was collected to measure the angiogenic factors sFlt1 and PLGF and their ratio (sFlt1/PLGF) by enzyme-linked immunosorbent assay (ELISA). By means of multiple regression models, the effect of the studied pollutants on the log-transformed concentrations of the angiogenic factors was evaluated. One hundred thirty-one patients were included. The log of the sFlt1/PLGF ratio increased with rising NO2 levels (p = 0.021 and beta = 0.206), and the log of the PLGF concentration showed a negative correlation with NO2 (p = 0.008 and beta = - 0.234). NO2, an indicator of the levels of primary air pollutants, presented significant positive correlation with an increased sFlt1/PLGF ratio and diminished PLGF levels, which may reflect an antiangiogenic state generated by air pollution exposure.
Palavras-chave
Air pollution, Placental growth factor (PLGF), Pregnancy, Angiogenic factors, Soluble fms-like tyrosine kinase 1 (sFlt1), First trimester
Referências
- de Oliveira BFA, 2014, J TOXICOL ENV HEAL B, V17, P369, DOI 10.1080/10937404.2014.976893
- Andikyan VM, 2000, B EXP BIOL MED+, V130, P715, DOI 10.1007/BF02682114
- Araneda S, 2008, NEUROTOXICOLOGY, V29, P920, DOI 10.1016/j.neuro.2008.09.006
- Bergen NE, 2015, HUM REPROD, V30, P1302, DOI 10.1093/humrep/dev070
- Blum JL, 2017, ENVIRON HEALTH PERSP, V125, DOI [10.1289/EHP1029, 10.1289/ehp1029]
- Brook RD, 2010, CIRCULATION, V121, P2331, DOI 10.1161/CIR.0b013e3181dbece1
- Canfield MA, 2006, J EXPO SCI ENV EPID, V16, P538, DOI 10.1038/sj.jes.7500501
- Cao ZJ, 2019, ENVIRON HEALTH-GLOB, V18, DOI 10.1186/s12940-019-0485-3
- Carneiro MFH, 2011, ENVIRON EXP BOT, V72, P272, DOI 10.1016/j.envexpbot.2011.04.001
- Conceicao GMS, 2001, ENVIRON HEALTH PERSP, V109, P347, DOI 10.2307/3434781
- Costa RA, 2016, HYPERTENS PREGNANCY, V35, P139, DOI 10.3109/10641955.2015.1115063
- Costa S, 2014, J TOXICOL ENV HEAL B, V17, P307, DOI 10.1080/10937404.2014.946164
- da Silva Agnes Soares, 2006, Environ Health, V5, P19, DOI 10.1186/1476-069X-5-19
- de Melo JO, 2015, TOXICOL LETT, V232, P475, DOI 10.1016/j.toxlet.2014.12.001
- Demir R, 2007, ACTA HISTOCHEM, V109, P257, DOI 10.1016/j.acthis.2007.02.008
- Filho HAG, 2008, ARCH GYNECOL OBSTET, V277, P195, DOI 10.1007/s00404-007-0453-y
- Hahad O, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21124306
- Hettfleisch K, 2017, ENVIRON HEALTH PERSP, V125, P753, DOI 10.1289/EHP300
- Janssen BG, 2013, PART FIBRE TOXICOL, V10, DOI 10.1186/1743-8977-10-22
- Jilani MH, 2020, ATHEROSCLEROSIS, V306, P22, DOI 10.1016/j.atherosclerosis.2020.06.018
- Kannan S, 2006, ENVIRON HEALTH PERSP, V114, P1636, DOI 10.1289/ehp.9081
- Kaufmann P, 2004, PLACENTA, V25, P114, DOI 10.1016/j.placenta.2003.10.009
- Kaufmann P, 2003, BIOL REPROD, V69, P1, DOI 10.1095/biolreprod.102.014977
- Khalil A, 2016, ULTRASOUND OBST GYN, V47, P324, DOI 10.1002/uog.15750
- Klepac P, 2018, ENVIRON RES, V167, P144, DOI 10.1016/j.envres.2018.07.008
- Lavigne E, 2016, ENVIRON RES, V148, P457, DOI 10.1016/j.envres.2016.04.026
- Liu SL, 2003, ENVIRON HEALTH PERSP, V111, P1773, DOI 10.1289/ehp.6251
- Malley CS, 2017, ENVIRON INT, V101, P173, DOI 10.1016/j.envint.2017.01.023
- Mayhew TM, 2009, J ANAT, V215, P77, DOI 10.1111/j.1469-7580.2008.00994.x
- McElrath TF, 2012, AM J OBSTET GYNECOL, V207, DOI 10.1016/j.ajog.2012.08.010
- Melody SM, 2019, ENVIRON POLLUT, V244, P915, DOI 10.1016/j.envpol.2018.10.086
- Mirowsky J, 2015, J EXPO SCI ENV EPID, V25, P354, DOI 10.1038/jes.2014.93
- Nicolaides, 2019, POON 2014 PRENATAL D
- Nobles CJ, 2019, SCI TOTAL ENVIRON, V650, P2641, DOI 10.1016/j.scitotenv.2018.09.362
- Novaes P, 2007, ENVIRON HEALTH PERSP, V115, P1753, DOI 10.1289/ehp.10363
- Olsson D, 2013, BMJ OPEN, V3, DOI 10.1136/bmjopen-2012-001955
- Pedersen M, 2014, HYPERTENSION, V64, P494, DOI 10.1161/HYPERTENSIONAHA.114.03545
- Pedersen M, 2013, LANCET RESP MED, V1, P695, DOI 10.1016/S2213-2600(13)70192-9
- Phipps EA, 2019, NAT REV NEPHROL, V15, P275, DOI 10.1038/s41581-019-0119-6
- Romao R, 2013, CAD SAUDE PUBLICA, V29, P1101, DOI [10.1590/S0102-311X2013000600007, 10.1590/S0102-311X2013001000007]
- de Andre CDS, 2014, ATMOS ENVIRON, V92, P178, DOI 10.1016/j.atmosenv.2014.04.023
- Sapkota A, 2012, AIR QUAL ATMOS HLTH, V5, P369, DOI 10.1007/s11869-010-0106-3
- Schuch D, 2019, ENVIRON SCI POLLUT R, V26, P31699, DOI 10.1007/s11356-019-06200-z
- Shah PS, 2011, ENVIRON INT, V37, P498, DOI 10.1016/j.envint.2010.10.009
- Olmo NRS, 2011, CLINICS, V66, P681, DOI 10.1590/S1807-59322011000400025
- Sircar M, 2015, CURR OPIN NEPHROL HY, V24, P131, DOI 10.1097/MNH.0000000000000105
- Steinle S, 2013, SCI TOTAL ENVIRON, V443, P184, DOI 10.1016/j.scitotenv.2012.10.098
- Sundrani D, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0054153
- van den Hooven EH, 2012, ENVIRON HEALTH PERSP, V120, P1753, DOI 10.1289/ehp.1204918
- van den Hooven EH, 2011, HYPERTENSION, V57, P406, DOI 10.1161/HYPERTENSIONAHA.110.164087
- Veras MM, 2008, BIOL REPROD, V79, P578, DOI 10.1095/biolreprod.108.069591
- Yorifuji T, 2015, SCI TOTAL ENVIRON, V508, P188, DOI 10.1016/j.scitotenv.2014.11.077
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Artigos e Materiais de Revistas Científicas - FM/MOG
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/05
Artigos e Materiais de Revistas Científicas - LIM/57
Carregar mais Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/05
Artigos e Materiais de Revistas Científicas - LIM/57