Biomarkers of occupational exposure to air pollution, inflammation and oxidative damage in taxi drivers

Imagem de Miniatura
Arquivos
art_SALDIVA_Biomarkers_of_occupational_exposure_to_air_pollution_inflammation_2013.PDF (778.68 KB)
Citações na Scopus
114
Tipo de produção
article
Data de publicação
2013
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER SCIENCE BV
Autores
BRUCKER, Natalia
MORO, Angela M.
CHARAO, Mariele F.
DURGANTE, Juliano
FREITAS, Fernando
BAIERLE, Marilia
NASCIMENTO, Sabrina
GAUER, Bruna
BULCAO, Rachel P.
BUBOLS, Guilherme B.
Citação
SCIENCE OF THE TOTAL ENVIRONMENT, v.463, p.884-893, 2013
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Exposure to environmental pollutants has been recognised as a risk factor for cardiovascular events. 1-hydroxypyrene (1-OHP) is a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs) from traffic-related air pollution. Experimental studies indicate that PAH exposure could be associated with inflammation and atherogenesis. Thus, the purpose of this study was to evaluate whether the biomarker of PAH exposure is associated with biomarkers of inflammation and oxidative stress and if these effects modulate the risk of developing cardiovascular diseases in workers exposed to air pollution. This study included 60 subjects, comprising 39 taxi drivers and 21 non-occupationally exposed persons. Environmental PM25 and benzo[a]pyrene (BaP) levels, in addition to biomarkers of exposure and oxidative damage, were determined. Inflammatory cytokines (IL-beta, IL-6, IL-10, TNF-alpha, IFN-gamma and hs-CRP) and serum levels of oxidised LDL (ox-LDL), auto-antibodies (ox-LDL-Ab) and homocysteine (Hcy) were also evaluated. PM25 and BaP exhibited averages of 12.4 6.914 IT1-beta and 1.0 0.6 ng M-3, respectively. Urinary 1-OHP levels were increased in taxi drivers compared to the non-occupationally exposed subjects (p < 0.05) and were positively correlated with pro-inflammatory cytokines and negatively correlated with antioxidants. Furthermore, taxi drivers had elevated pro-inflammatory cytokines, biomarkers of oxidative damage, and ox-LDL, ox-LDL-Ab and Hcy levels, although antioxidant enzymes were decreased compared to the non-occupationally exposed subjects (p < 0.05). In summary, our findings indicate that taxi drivers showed major exposure to pollutants, such as PAHs, in relation to non-occupationally exposed subjects. This finding was associated with higher inflammatory biomarkers and Hcy, which represent important predictors for cardiovascular events. These data suggest a contribution of PAHs to cardiovascular diseases upon occupational exposure.
Palavras-chave
Occupational exposure, 1-hydroxypyrene, Inflammation, Oxidative stress, Taxi drivers
URI
https://observatorio.fm.usp.br/handle/OPI/4254
Referências
  1. AEBI H, 1984, METHOD ENZYMOL, V105, P121
  2. Andrade MD, 2012, AIR QUAL ATMOS HLTH, V5, P79, DOI 10.1007/s11869-010-0104-5
  3. Aoki T, 2012, LIPIDS HEALTH DIS, V11, DOI 10.1186/1476-511X-11-4
  4. Araujo JA, 2009, PART FIBRE TOXICOL, V6, DOI 10.1186/1743-8977-6-24
  5. Bagryantseva Y, 2010, TOXICOL LETT, V199, P60, DOI 10.1016/j.toxlet.2010.08.007
  6. Baierle M, 2012, QUIM NOVA, V35, P403, DOI 10.1590/S0100-40422012000200030
  7. Barter PJ, 2004, CIRC RES, V95, P764, DOI 10.1161/01.RES.0000146094.59640.13
  8. BEUTLER E, 1984, CLIN CHEM, V30, P871
  9. Bhatnagar A, 2006, CIRC RES, V99, P692, DOI 10.1161/01.RES.0000243586.99701.cf
  10. Bono R, 2007, SCI TOTAL ENVIRON, V376, P109, DOI 10.1016/j.scitotenv.2007.01.086
  11. Brook RD, 2009, HYPERTENSION, V54, P659, DOI 10.1161/HYPERTENSIONAHA.109.130237
  12. Brook RD, 2008, CLIN SCI, V115, P175, DOI 10.1042/CS20070444
  13. Buijsse B, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0038901
  14. Burgaz S, 2002, CHEMOSPHERE, V47, P57, DOI 10.1016/S0045-6535(01)00185-0
  15. Burtis CA, 2008, TIETZ FUNDAMENTOS CL
  16. Buss H, 1997, FREE RADICAL BIO MED, V23, P361, DOI 10.1016/S0891-5849(97)00104-4
  17. Castano-Vinyals G, 2004, OCCUP ENVIRON MED, V61, DOI 10.1136/oem.2003.008375
  18. Curfs DMJ, 2004, AM J PATHOL, V164, P101, DOI 10.1016/S0002-9440(10)63101-X
  19. Delfino RJ, 2009, ENVIRON HEALTH PERSP, V117, P1232, DOI 10.1289/ehp.0800194
  20. Demetriou CA, 2012, OCCUP ENVIRON MED, V69, P619, DOI 10.1136/oemed-2011-100566
  21. de Miranda RM, 2012, AIR QUAL ATMOS HLTH, V5, P63, DOI 10.1007/s11869-010-0124-1
  22. Desai A, 2001, INFLAMMATION, V25, P179, DOI 10.1023/A:1011088431191
  23. ELLMAN GL, 1959, ARCH BIOCHEM BIOPHYS, V82, P70, DOI 10.1016/0003-9861(59)90090-6
  24. Espinola-Klein C, 2007, AM J CARDIOL, V99, P808, DOI 10.1016/j.amjcard.2006.10.041
  25. Fan RF, 2012, ENVIRON INT, V42, P53, DOI 10.1016/j.envint.2011.03.021
  26. Freire C, 2009, SCI TOTAL ENVIRON, V407, P1562, DOI 10.1016/j.scitotenv.2008.10.068
  27. FRIEDEWA.WT, 1972, CLIN CHEM, V18, P499
  28. Grotto D, 2007, J PHARMACEUT BIOMED, V43, P619, DOI 10.1016/j.jpba.2006.07.030
  29. HABIG WH, 1974, J BIOL CHEM, V249, P7130
  30. HALLIWELL B, 1992, J LAB CLIN MED, V119, P598
  31. Hansen AM, 2004, MUTAT RES-GEN TOX EN, V557, P7, DOI 10.1016/j.mrgentox.2003.09.007
  32. Hansen AM, 2008, INT J HYG ENVIR HEAL, V211, P471, DOI 10.1016/j.ijheh.2007.09.012
  33. Holvoet P, 1998, ARTERIOSCL THROM VAS, V18, P100
  34. Hong YC, 2009, TOXICOL LETT, V184, P139, DOI 10.1016/j.toxlet.2008.11.001
  35. Huang HB, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0037412
  36. Huttunen K, 2012, ENVIRON RES, V116, P44, DOI 10.1016/j.envres.2012.04.004
  37. Jaffe M., 1886, Z PHYSL CHEM, V10, P391
  38. JONGENEELEN FJ, 1988, ANN OCCUP HYG, V32, P35, DOI 10.1093/annhyg/32.1.35
  39. Knaapen AM, 2007, MUTAT RES-FUND MOL M, V621, P31, DOI 10.1016/j.mrfmmm.2006.12.010
  40. Kunzli N, 2005, ENVIRON HEALTH PERSP, V113, P201, DOI 10.1289/ehp.7523
  41. Lasheras C, 2002, FREE RADICAL RES, V36, P875, DOI 10.1080/1071576021000005311
  42. Lewne M, 2006, INT ARCH OCC ENV HEA, V79, P220, DOI 10.1007/s00420-005-0047-6
  43. Liu HH, 2010, INT J HYG ENVIR HEAL, V213, P93, DOI 10.1016/j.ijheh.2009.12.005
  44. Lodovici M, 2011, J TOXICOL, V2011, P9, DOI [10.1155/2011/487074, DOI 10.1155/2011/487074]
  45. Manini P, 2006, TOXICOL LETT, V167, P142, DOI 10.1016/j.toxlet.2006.08.016
  46. Manno M, 2010, TOXICOL LETT, V192, P3, DOI 10.1016/j.toxlet.2009.05.001
  47. Marie C, 2009, ENVIRON MOL MUTAGEN, V50, P88, DOI 10.1002/em.20439
  48. Marotta F, 2011, J BIOL REG HOMEOS AG, V25, P221
  49. Merlo F, 1998, CANCER EPIDEM BIOMAR, V7, P147
  50. Mills NL, 2009, NAT CLIN PRACT CARD, V6, P36, DOI 10.1038/ncpcardio1399
  51. Mineo C, 2006, CIRC RES, V98, P1352, DOI 10.1161/01.RES.0000225982.01988.93
  52. Moller P, 1996, CHEM-BIOL INTERACT, V102, P17, DOI 10.1016/0009-2797(96)03729-5
  53. PAGLIA DE, 1967, J LAB CLIN MED, V70, P158
  54. Pereira CEL, 2007, BRAZ J MED BIOL RES, V40, P1353, DOI 10.1590/S0100-879X2006005000164
  55. Perla-Kajan J, 2007, AMINO ACIDS, V32, P561, DOI 10.1007/s00726-006-0432-9
  56. Petchpoung K, 2011, ENVIRON TOXICOL PHAR, V31, P160, DOI 10.1016/j.etap.2010.10.006
  57. Piccardo MT, 2004, SCI TOTAL ENVIRON, V330, P39, DOI 10.1016/j.scitotenv.2004.02.024
  58. Podechard N, 2008, TOXICOL LETT, V177, P130, DOI 10.1016/j.toxlet.2008.01.006
  59. Pope CA, 2002, JAMA-J AM MED ASSOC, V287, P1132, DOI 10.1001/jama.287.9.1132
  60. Pope CA, 2004, ENVIRON HEALTH PERSP, V112, P339, DOI 10.1289/ehp.6588
  61. Roehrs M, 2011, BMC NEPHROL, V12, DOI 10.1186/1471-2369-12-59
  62. Rossner P, 2008, MUTAT RES-FUND MOL M, V642, P21, DOI 10.1016/j.mrfmmm.2008.03.004
  63. SALONEN JT, 1992, LANCET, V339, P883
  64. Schnabel R, 2005, J AM COLL CARDIOL, V45, P1631, DOI 10.1016/j.jacc.2005.02.053
  65. Sellappa S, 2011, ASIAN PAC J CANCER P, V12, P713
  66. Sharman JE, 2002, ARCH ENVIRON HEALTH, V57, P536
  67. Sivonova M, 2004, STRESS, V7, P183, DOI 10.1080/10253890400012685
  68. Soares SRC, 2009, ATHEROSCLEROSIS, V207, P368, DOI 10.1016/j.atherosclerosis.2009.04.041
  69. Sorensen M, 2003, MUTAT RES-REV MUTAT, V544, P255, DOI 10.1016/j.mrrev.2003.06.010
  70. Steinvil A, 2008, ENVIRON RES, V106, P51, DOI 10.1016/j.envres.2007.08.006
  71. Teixeira EC, 2009, ATMOS ENVIRON, V43, P2213, DOI 10.1016/j.atmosenv.2008.12.051
  72. Umannova L, 2011, TOXICOL LETT, V206, P121, DOI 10.1016/j.toxlet.2011.06.029
  73. US EPA, 2002, POL ORG MATT
  74. Vogel CFA, 2005, ENVIRON HEALTH PERSP, V113, P1536, DOI 10.1289/ehp.8094
  75. World Health Organization, 2005, WHO AIR QUAL GUID PA
  76. WU R, 1995, CLIN EXP IMMUNOL, V102, P174
  77. Yoon HS, 2012, INT J HYG ENVIR HEAL, V215, P458, DOI 10.1016/j.ijheh.2012.02.007
  78. Yoshida T, 2010, BIOL PHARM BULL, V33, P7

Coleções
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/05
Artigos e Materiais de Revistas Científicas - ODS/03
Artigos e Materiais de Revistas Científicas - ODS/11