Chronic inflammatory diseases, subclinical atherosclerosis, and cardiovascular diseases: Design, objectives, and baseline characteristics of a prospective case-cohort study-ELSA-Brasil
Carregando...
Citações na Scopus
1
Tipo de produção
article
Data de publicação
2022
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER ESPANA
Autores
ALENCAR, Airlane
TELLES, Rosa W.
MACHADO, Luciana Andrade Carneiro
BARRETO, Sandhi Maria
Citação
CLINICS, v.77, article ID 100013, 7p, 2022
Resumo
Objectives: This analysis describes the protocol of a study with a case-cohort to design to prospectively evaluate the incidence of subclinical atherosclerosis and Cardiovascular Disease (CVD) in Chronic Inflammatory Disease (CID) participants compared to non-diseased ones. Methods: A high-risk group for CID was defined based on data collected in all visits on self-reported medical diagnosis, use of medicines, and levels of high-sensitivity C-Reactive Protein >10 mg/L. The comparison group is the Aleatory Cohort Sample (ACS): a group with 10% of participants selected at baseline who represent the entire cohort. In both groups, specific biomarkers for DIC, markers of subclinical atherosclerosis, and CVD morbimortality will be tested using weighted Cox. Results: The high-risk group (n = 2,949; aged 53.6 +/- 9.2; 65.5% women) and the ACS (n=1543; 52.2 +/- 8.8; 54.1% women) were identified. Beyond being older and mostly women, participants in the high-risk group present low average income (29.1% vs. 24.8%, p < 0.0001), higher BMI (Kg/m2) (28.1 vs. 26.9, p < 0.0001), higher waist circumference (cm) (93.3 vs. 91, p < 0.0001), higher frequencies of hypertension (40.2% vs. 34.5%, p < 0.0001), diabetes (20.7% vs. 17%, p = 0.003) depression (5.8% vs. 3.9%, p = 0.007) and higher levels of GlycA a new inflammatory marker (p < 0.0001) compared to the ACS. Conclusions: The high-risk group selected mostly women, older, lower-income/education, higher BMI, waist circumference, and of hypertension, diabetes, depression, and higher levels of GlycA when compared to the ACS. The strategy chosen to define the high-risk group seems adequate given that multiple sociodemographic and clinical characteristics are compatible with CID.
Palavras-chave
Cardiovascular disease, Coronary artery calcium (CAC), Carotid intima-media thickness (CIMT), Fatal and non-fatal cardiovascular events
Referências
- AGATSTON AS, 1990, J AM COLL CARDIOL, V15, P827, DOI 10.1016/0735-1097(90)90282-T
- Aquino EML, 2012, AM J EPIDEMIOL, V175, P315, DOI 10.1093/aje/kwr294
- Barlow WE, 1999, J CLIN EPIDEMIOL, V52, P1165, DOI 10.1016/S0895-4356(99)00102-X
- Behl T, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21249505
- Bensenor IM, 2016, AM HEART J, V174, P51, DOI 10.1016/j.ahj.2015.12.018
- Bensenor IM, 2013, REV SAUDE PUBL, V47, P37, DOI 10.1590/S0034-8910.2013047003780
- Boo S, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0176291
- Brant Luisa Campos Caldeira, 2017, Rev. bras. epidemiol., V20, P116, DOI 10.1590/1980-5497201700050010
- Cai RX, 2020, J HYPERTENS, V38, P1632, DOI 10.1097/HJH.0000000000002442
- Chor D, 2013, REV SAUDE PUBL, V47, P27, DOI 10.1590/S0034-8910.2013047003835
- Conroy RM, 2003, EUR HEART J, V24, P987, DOI 10.1016/S0195-668X(03)00114-3
- Cooksey R, 2018, SEMIN ARTHRITIS RHEU, V48, P367, DOI 10.1016/j.semarthrit.2018.03.005
- Fedeli LG, 2013, REV SAUDE PUBL, V47, P63, DOI 10.1590/S0034-8910.2013047003807
- FOURNET B, 1978, BIOCHEMISTRY-US, V17, P5206, DOI 10.1021/bi00617a021
- Giles JT, 2019, ARTHRITIS RHEUMATOL, V71, P1426, DOI 10.1002/art.40889
- Goff DC, 2014, J AM COLL CARDIOL, V63, P2935, DOI [10.1016/j.jacc.2013.11.005, 10.1161/01.cir.0000437741.48606.98]
- Gu MM, 2019, IMMUNOL INVEST, V48, P505, DOI 10.1080/08820139.2019.1567534
- Hippisley-Cox J, 2007, BMJ-BRIT MED J, V335, P136, DOI 10.1136/bmj.39261.471806.55
- Jeyarajah EJ, 2006, CLIN LAB MED, V26, P847, DOI 10.1016/j.cll.2006.07.006
- Jonsson R, 2013, JAMA-J AM MED ASSOC, V310, P1854, DOI 10.1001/jama.2013.278448
- Kuller LH, 2014, ARTHRITIS RHEUMATOL, V66, P497, DOI 10.1002/art.38268
- Laurent S, 2012, ANN MED, V44, pS93, DOI 10.3109/07853890.2011.653398
- LEWIS G, 1992, PSYCHOL MED, V22, P465, DOI 10.1017/S0033291700030415
- Libby P, 2018, J AM COLL CARDIOL, V72, P2071, DOI 10.1016/j.jacc.2018.08.1043
- Lohman TG, ANTHROPOMETRIC STAND
- Lotufo PA, 2015, SAO PAULO MED J, V133, P69, DOI 10.1590/1516-3180.2015.13320018
- Mill JG, 2013, REV SAUDE PUBL, V47, P54, DOI 10.1590/S0034-8910.2013047003851
- Myasoedova E, 2011, ANN RHEUM DIS, V70, P482, DOI 10.1136/ard.2010.135871
- Onland-Moret NC, 2007, J CLIN EPIDEMIOL, V60, P350, DOI 10.1016/j.jclinepi.2006.06.022
- Pereira AC, 2016, CLIN CARDIOL, V39, P352, DOI 10.1002/clc.22539
- Pereira AC, 2013, REV SAUDE PUBL, V47, P72, DOI 10.1590/S0034-8910.2013047003822
- Pradhan AD, 2002, JAMA-J AM MED ASSOC, V288, P980, DOI 10.1001/jama.288.8.980
- PRENTICE RL, 1986, BIOMETRIKA, V73, P1
- Ridker PM, 2007, JAMA-J AM MED ASSOC, V297, P611, DOI 10.1001/jama.297.6.611
- Ridker PM, 2000, NEW ENGL J MED, V342, P836, DOI 10.1056/NEJM200003233421202
- Rivera TL, 2009, ANN RHEUM DIS, V68, P828, DOI 10.1136/ard.2008.088054
- Roth GA, 2020, J AM COLL CARDIOL, V76, P2982, DOI 10.1016/j.jacc.2020.11.010
- Roth GA, 2018, LANCET, V392, P1736, DOI 10.1016/s0140-6736(18)32203-7
- Santos IS, 2014, ATHEROSCLEROSIS, V237, P227, DOI 10.1016/j.atherosclerosis.2014.09.004
- Schmidt MI, 2015, INT J EPIDEMIOL, V44, P68, DOI 10.1093/ije/dyu027
- Sultan AA, 2015, GUT, V64, P1220, DOI 10.1136/gutjnl-2014-308285
- Theander E, 2015, ARTHRITIS RHEUMATOL, V67, P2427, DOI 10.1002/art.39214
- Treff C, 2017, J HUM HYPERTENS, V31, P278, DOI 10.1038/jhh.2016.75
- Tunstall-Pedoe H., 2005, PREVENTING CHRONIC D, P200
- World Health Organization, 2004, ICD 10 INT CLASSIFIC
Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - FM/MCP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - HU
Artigos e Materiais de Revistas Científicas - LIM/07
Carregar mais Artigos e Materiais de Revistas Científicas - FM/MCP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - HU
Artigos e Materiais de Revistas Científicas - LIM/07