Parental age and the risk of bipolar disorder in the offspring: A systematic review and meta-analysis

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Arquivos
art_POLGA_Parental_age_and_the_risk_of_bipolar_disorder_2022.PDF (1.33 MB)
Citações na Scopus
6
Tipo de produção
article
Data de publicação
2022
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY
Autores
POLGA, Natalia
BLOCH, Michael H.
Citação
ACTA PSYCHIATRICA SCANDINAVICA, v.145, n.6, p.568-577, 2022
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Objectives Whether parental age, i.e., paternal or maternal, at childbirth is associated with the risk of bipolar disorder (BD) in offspring remains unclear. We conducted a meta-analysis of observational studies to address this gap. Methods PubMed, PsycINFO, Embase, and Web of Science were searched up to June 2021. Studies investigating the associations between parental age at childbirth (exposure) and the risk of BD in offspring (outcome) were eligible for inclusion in our study. Paternal and maternal age were examined separately. Odds ratio (OR) was used as the effect size index. Data were pooled through random-effects meta-analyses. Results Seven studies involving 3,183,539 participants and 23,253 individuals with BD were included in our meta-analyses. Meta-analyses indicated an increased risk of BD in the offspring of the older paternal age groups (35-44 years old [k = 5; OR = 1.09; 95% CI 1.05, 1.14; p < 0.0001] and >= 45 years old [k = 5; OR = 1.44; 95% CI 1.19, 1.14; p = 0.0001]) in comparison with the reference category (25-34 years old). Meta-analysis also indicated an increased risk of BD in the offspring of the older maternal age group (>= 40 years old [k = 3; OR = 1.20; 95% CI 1.10, 1.31; p < 0.0001]) in comparison with the reference category (20-29 years old). Conclusions Advanced paternal and maternal age were both associated with an increased risk of BD in offspring. Further studies are needed to investigate the mechanisms behind this association.
Palavras-chave
bipolar disorder, epidemiology, meta-analysis [publication type], parents, risk factors
URI
https://observatorio.fm.usp.br/handle/OPI/47243
Referências
  1. Agnew-Blais J, 2016, LANCET PSYCHIAT, V3, P342, DOI 10.1016/S2215-0366(15)00544-1
  2. Balduzzi S, 2019, EVID-BASED MENT HEAL, V22, P153, DOI 10.1136/ebmental-2019-300117
  3. Birur B, 2017, NPJ SCHIZOPHR, V3, DOI 10.1038/s41537-017-0013-9
  4. Bortolato B, 2017, BIPOLAR DISORD, V19, P84, DOI 10.1111/bdi.12490
  5. Brown A, 2013, PSYCHIAT RES, V208, P225, DOI 10.1016/j.psychres.2013.05.024
  6. Buizer-Voskamp JE, 2011, SCHIZOPHR RES, V129, P128, DOI 10.1016/j.schres.2011.03.021
  7. Cao B, 2019, NORD J PSYCHIAT, DOI 10.1080/08039488.2018.1529196
  8. Chudal R, 2014, BIPOLAR DISORD, V16, P624, DOI 10.1111/bdi.12182
  9. Collaborators G, 2019, LANCET PSYCHIAT
  10. Crippa A, 2016, J STAT SOFTW, V72, DOI 10.18637/jss.v072.c01
  11. Dickstein DP, 2017, J AM ACAD CHILD PSY, V56, P369, DOI 10.1016/j.jaac.2017.03.005
  12. Elbers RG, 2019, CHAPTER 8 ASSESSING
  13. Fountoulakis KN, 2019, INT J PSYCHIAT CLIN, V23, P90, DOI 10.1080/13651501.2018.1519079
  14. Frans EM, 2016, PSYCHOL MED, V46, P2981, DOI 10.1017/S0033291716001744
  15. Goes FS, 2021, MOL PSYCHIATR, V26, P4127, DOI 10.1038/s41380-019-0611-1
  16. Goldmann JM, 2019, TRENDS GENET, V35, P828, DOI 10.1016/j.tig.2019.08.005
  17. Goldmann JM, 2016, NAT GENET, V48, P935, DOI 10.1038/ng.3597
  18. Gratten J, 2016, NAT GENET, V48, P718, DOI 10.1038/ng.3577
  19. Hultman CM, 2012, SCHIZOPHR RES, V136, pS3, DOI 10.1016/S0920-9964(12)70012-9
  20. Khan A, 2019, PLOS BIOL, V17, DOI 10.1371/journal.pbio.3000353
  21. Kupfer DJ, 2005, JAMA-J AM MED ASSOC, V293, P2528, DOI 10.1001/jama.293.20.2528
  22. Lehrer DS, 2016, AM J MED GENET B, V171, P495, DOI 10.1002/ajmg.b.32334
  23. Lichtenstein P, 2009, LANCET, V373, P234, DOI 10.1016/S0140-6736(09)60072-6
  24. Malaspina D, 2001, ARCH GEN PSYCHIAT, V58, P361, DOI 10.1001/archpsyc.58.4.361
  25. Malhotra D, 2011, NEURON, V72, P951, DOI 10.1016/j.neuron.2011.11.007
  26. McGrath JJ, 2014, JAMA PSYCHIAT, V71, P301, DOI 10.1001/jamapsychiatry.2013.4081
  27. Miller B, 2011, SCHIZOPHRENIA BULL, V37, P1039, DOI 10.1093/schbul/sbq011
  28. Page MJ, 2021, BMJ-BRIT MED J, V372, DOI 10.1136/bmj.n71
  29. Polderman TJC, 2015, NAT GENET, V47, P702, DOI 10.1038/ng.3285
  30. Post RM, 2016, BIPOLAR DISORD, V18, P315, DOI 10.1111/bdi.12401
  31. Priebe L, 2012, MOL PSYCHIATR, V17, P421, DOI 10.1038/mp.2011.8
  32. Shao L, 2008, BIOL PSYCHIAT, V64, P89, DOI 10.1016/j.biopsych.2007.11.010
  33. Smoller JW, 2003, AM J MED GENET C, V123C, P48, DOI 10.1002/ajmg.c.20013
  34. Solmi M, 2022, MOL PSYCHIATR, V27, P281, DOI 10.1038/s41380-021-01161-7
  35. Talati A, 2013, AM J PSYCHIAT, V170, P1178, DOI 10.1176/appi.ajp.2013.12121500
  36. Uher R, 2014, FRONT PSYCHIATRY, V5, DOI 10.3389/fpsyt.2014.00048
  37. Vervoort I, 2022, PEDIATR RES, V91, P757, DOI 10.1038/s41390-021-01435-4
  38. Vieta E, 2018, NAT REV DIS PRIMERS, V4, DOI 10.1038/nrdp.2018.8
  39. Weiser M, 2020, PSYCHOL MED, V50, P431, DOI 10.1017/S0033291719000242
  40. Wells G., NEWCASTLE OTTAWA SCA
  41. Wohl M, 2007, EUR PSYCHIAT, V22, P22, DOI 10.1016/j.eurpsy.2006.08.007
  42. Wu S, 2017, ACTA PSYCHIAT SCAND, V135, P29, DOI 10.1111/acps.12666

Coleções
Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - LIM/21
Artigos e Materiais de Revistas Científicas - LIM/23