Predementic diagnosis and biomarkers of dementia in Alzheimer's disease
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2012
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NOVA SCIENCE PUBLISHERS, INC.
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Citação
Forlenza, O. V.; Diniz, B. S.; Gattaz, W. F.. Predementic diagnosis and biomarkers of dementia in Alzheimer's disease. In: . RESEARCH PROGRESS IN ALZHEIMER'S DISEASE AND DEMENTIA (V): NOVA SCIENCE PUBLISHERS, INC., 2012. p.113-140.
Resumo
In next decades, Alzheimer's disease (AD) will reach an epidemic status unless more effective therapeutic interventions are made available. These treatments should target the modification of specific pathological cascades that lead to neurodegeneration in AD. There is evidence of a long pre-clinical stage in AD, in which neuritic plaques and neurofibrillary tangles gradually accumulate in affected brain areas. At the earliest stages of this process, no significant cognitive or functional impairment is detected by conventional clinical methods. New technologies based on structural and functional neuroimaging, and on the biochemical analysis of cerebrospinal fluid may depict correlates of intracerebral pathology in individuals with mild, pre-dementia symptoms. These methods are commonly referred to as AD-related biomarkers. Therefore, the combination of clinical and biological information yields better diagnostic accuracy to identify individuals at high risk of AD. The relevance of this diagnosis relies on the hypothesis that pharmacological interventions with disease-modifying compounds are likely to produce clinically relevant benefits if started early enough in the continuum towards dementia. In this paper, we review the clinical characteristics of the prodromal and transitional states from normal cognitive ageing to dementia in AD. We further address recent developments in biomarker research to support the early diagnosis and prediction of dementia, and discuss the challenges and perspectives for the development of disease-modifying therapies. © 2012 by Nova Science Publishers, Inc. All rights reserved.
Palavras-chave
Alzheimer's disease, Amyloid-β protein, Biomarkers, Mild cognitive impairment, Neuroimaging, Pathophysiology, Tau protein
Referências
- Abreu, I.D., Nunes, P.V., Diniz, B.S., Forlenza, O.V., Combining functional scales and cognitive tests in screening for mild cognitive impairment at a university-based memory clinic in Brazil (2008) Rev Bras Psiquiatr, 30 (4), pp. 346-349
- Aisen, P.S., Saumier, D., Briand, R., Laurin, J., Gervais, F., Tremblay, P., Garceau, D., A Phase II study targeting amyloid-beta with 3APS in mild-to-moderate Alzheimer disease (2006) Neurology, 67, pp. 1757-1763
- Aizenstein, H.J., Nebes, R.D., Saxton, J.A., Price, J., Mathis, C., Tsopelas, N.D., Ziolko, S.K., Houck, P.R., Frequent amyloid deposition without significant cognitive impairment among the elderly (2008) Arch Neurol, 65, pp. 1509-1517
- Albert, M.S., DeKosky, S.T., Dickson, D., Dubois, B., Feldman, H.H., Fox, N.C., Gamst, A., Phelps, C.H., The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease (2011) Alzheimers Dement, 7 (3), pp. 270-279
- Andreasen, N., Minthon, L., Davidsson, P., Vanmechelen, E., Vanderstichele, H., Winblad, B., Blennow, K., Evaluation of CSF-tau and CSF-Abeta42 as diagnostic markers for Alzheimer disease in clinical practice (2001) Arch Neurol, 58, pp. 373-379
- Apostolova, L.G., Dinov, I.D., Dutton, R.A., Hayashi, K.M., Toga, A.W., Cummings, J.L., Thompson, P.M., 3D comparison of hippocampal atrophy in amnestic mild cognitive impairment and Alzheimer's disease (2006) Brain, 129, pp. 2867-2873
- Arai, H., Ishiguro, K., Ohno, H., Moriyama, M., Itoh, N., Okamura, N., Matsui, T., Kohno, H., CSF phosphorylated tau protein and mild cognitive impairment: a prospective study (2000) Exp Neurol, 166, pp. 201-203
- Assini, A., Cammarata, S., Vitali, A., Colucci, M., Giliberto, L., Borghi, R., Inglese, M.L., Dagna-Bricarelli, F., Plasma levels of amyloid beta-protein 42 are increased in women with mild cognitive impairment (2004) Neurology, 63, pp. 828-831
- Barbosa, I., Huguet, R., Mendonça, V., Sousa, L., Neves, F., Bauer, M., Teixeira, A., Increased plasma levels of soluble TNF receptor I in patients with bipolar disorder (2011) Eur Arch Psychiatry Clin Neurosci, 261 (2), pp. 139-143
- Blacker, D., Lee, H., Muzikansky, A., Martin, E.C., Tanzi, R., McArdle, J.J., Moss, M., Albert, M., Neuropsychological measures in normal individuals that predict subsequent cognitive decline (2007) Arch Neurol, 64, pp. 862-871
- Blasko, I., Jellinger, K., Kemmler, G., Krampla, W., Jungwirth, S., Wichart, I., Tragl, K.H., Fischer, P., Conversion from cognitive health to mild cognitive impairment and Alzheimer's disease: prediction by plasma amyloid beta 42, medial temporal lobe atrophy and homocysteine (2008) Neurobiol Aging, 29, pp. 1-11
- Blass, J.P., Alzheimer's disease and Alzheimer's dementia: distinct but overlapping entities (2002) Neurobiol Aging, 23, pp. 1077-1084
- Blennow, K., Hampel, H., CSF markers for incipient Alzheimer's disease (2003) Lancet Neurol, 2, pp. 605-613
- Blennow, K., Cerebrospinal fluid protein biomarkers for Alzheimer's disease (2004) NeuroRx, 1, pp. 213-225
- Blennow, K., Hampel, H., Weiner, M., Zetterberg, H., Cerebrospinal fluid and plasma biomarkers in Alzheimer disease (2010) Nat Rev Neurol, 6 (3), pp. 131-144
- Bouwman, F.H., Schoonenboom, S.N., van der Flier, W.M., van Elk, E.J., Kok, A., Barkhof, F., Blankenstein, M.A., Scheltens, P., CSF biomarkers and medial temporal lobe atrophy predict dementia in mild cognitive impairment (2007) Neurobiol Aging, 28, pp. 1070-1074
- Brookmeyer, R., Gray, S., Kawas, C., Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset (1998) Am J Public Health, 88, pp. 1337-1342
- Brookmeyer, R., Gray, S., Kawas, C., Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset (1998) Am J Public Health, 88, pp. 1337-1342
- Brookmeyer, R., Johnson, E., Ziegler-Graham, K., Arrighi, H.M., Forecasting the global burden of Alzheimer's disease (2007) Alzheimers Dement, 3, pp. 186-191
- Bruscoli, M., Lovestone, S., Is MCI really just early dementia? A systematic review of conversion studies (2004) Int Psychogeriatr, 16 (2), pp. 129-140
- Brys, M., Pirraglia, E., Rich, K., Rolstad, S., Mosconi, L., Switalski, R., Glodzik-Sobanska, L., Mehta, P., Prediction and longitudinal study of CSF biomarkers in mild cognitive impairment (2009) Neurobiol Aging, 30, pp. 682-690
- Buchhave, P., Zetterberg, H., Blennow, K., Minthon, L., Janciauskiene, S., Hansson, O., Soluble TNF receptors are associated with Abeta metabolism and conversion to dementia in subjects with mild cognitive impairment (2008) Neurobiology of Aging, , [ahead of print]
- Buerger, K., Ewers, M., Pirttil, T., Zinkowski, R., Alafuzoff, I., Teipel, S.J., DeBernardis, J., Soininen, H., CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease (2006) Brain, 129, pp. 3035-3041
- Burton, C.L., Strauss, E., Bunce, D., Hunter, M.A., Hultsch, D.F., Functional abilities in older adults with mild cognitive impairment (2009) Gerontology, 55 (5), pp. 570-581
- Busatto, G.F., Diniz, B.S., Zanetti, M.V., Voxel-based morphometry in Alzheimer's disease (2008) Expert Rev Neurother, 8, pp. 1691-1702
- Busse, A., Hansel, A., Gühne, U., Angermeyer, M.C., Riedel-Heller, S.G., Mild cognitive impairment: long-term course of four clinical subtypes (2006) Neurology, 67, pp. 2176-2185
- Caroli, A., Frisoni, G., the Alzheimer's Disease Neuroimaging I. The dynamics of Alzheimer's disease biomarkers in the Alzheimer's Disease Neuroimaging Initiative cohort (2010) Neurobiol Aging, 31 (8), pp. 1263-1274
- Chetelat, G., Desgranges, B., de la Sayette, V., Viader, F., Eustache, F., Baron, J.C., Mild cognitive impairment: Can FDG-PET predict who is to rapidly convert to Alzheimer's disease? (2003) Neurology, 60 (8), pp. 1374-1377
- Chetelat, G., Landeau, B., Eustache, F., Mezenge, F., Viader, F., de la Sayette, V., Desgranges, B., Baron, J.C., Using voxel-based morphometry to map the structural changes associated with rapid conversion in MCI: a longitudinal MRI study (2005) NeuroImage, 27, pp. 934-946
- Chetelat, G., Eustache, F., Viader, F., De La Sayette, V., Pölerin, A., Mäzenge, F., Hannequin, D., Desgranges, B., FDG-PET measurement is more accurate than neuropsychological assessments to predict global cognitive deterioration in patients with mild cognitive impairment (2005) Neurocase, 11 (1), pp. 14-25
- Citron, M., Alzheimer's disease: strategies for disease modification (2010) Nat Rev Drug Discov, 9, pp. 387-398
- Clark, C., Xie, S., Chittams, J., Ewbank, D., Peskind, E., Galasko, D., Morris, J., Weitlauf, S.L., Cerebrospinal fluid tau and beta-amyloid: how well do these biomarkers reflect autopsy-confirmed dementia diagnoses? (2003) Arch Neurol, 60, pp. 1696-1702
- Cunningham, C., Campion, S., Lunnon, K., Murray, C.L., Woods, J.F., Deacon, R.M., Rawlins, J.N., Perry, V.H., Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease (2009) Biol Psychiatry, 65, pp. 304-312
- Davatzikos, C., Xu, F., An, Y., Fan, Y., Resnick, S.M., Longitudinal progression of Alzheimer's-like patterns of atrophy in normal older adults: the SPARE-AD index (2009) Brain, 132, pp. 2026-2035
- de Leon, M.J., Convit, A., Wolf, O.T., Tarshish, C.Y., DeSanti, S., Rusinek, H., Tsui, W., Fowler, J., Prediction of cognitive decline in normal elderly subjects with 2-[(18)F]fluoro-2-deoxy-D-glucose/poitron-emission tomography (FDG/PET) (2001) Proc Natl Acad Sci USA, 98 (19), pp. 10966-10971
- Diniz, B., Pinto, J., Forlenza, O.V., Do CSF total tau, phosphorylated tau, and β-amyloid 42 help to predict progression of mild cognitive impairment to Alzheimer's disease? A systematic review and meta-analysis of the literature (2008) World J Biol Psychiatry, 9 (3), pp. 172-182
- Diniz, B.S., Nunes, P.V., Yassuda, M.S., Forlenza, O., Diagnosis of mild cognitive impairment revisited after one year. Preliminary results of a prospective study (2009) Dement Geriatr Cogn Disord, 27, pp. 224-231
- Diniz, B.S., Pinto, J.A., Gonzaga, M.L., Guimarães, F.M., Gattaz, W.F., Forlenza, O.V., To treat or not to treat? A meta-analysis of the use of cholinesterase inhibitors in mild cognitive impairment for delaying progression to Alzheimer's disease (2009) Eur Arch Psychiatry Clin Neurosci, 259, pp. 248-256
- Diniz, B.S., Teixeira, A.L., Talib, L.L., Mendonça, V.A., Gattaz, W.F., Forlenza, O.V., Serum brain-derived neurotrophic factor level is reduced in antidepressant-free patients with late-life depression (2010) World J Biol Psychiatry, 11 (3), pp. 550-555
- Drzezga, A., Grimmer, T., Riemenschneider, M., Lautenschlager, N., Siebner, H., Alexopoulus, P., Minoshima, S., Kurz, A., Prediction of individual clinical outcome in MCI by means of genetic assessment and (18)F-FDG PET (2005) J Nucl Med, 46 (10), pp. 1625-1632
- Dubois, B., Feldman, H.H., Jacova, C., Dekosky, S., Barberger-Gateau, P., Cummings, J., Delacourte, A., Jicha, G., Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria (2007) Lancet Neurol, 6, pp. 734-746
- Edison, P., Archer, H.A., Hinz, R., Hammers, A., Pavese, N., Tai, Y.F., Hotton, G., Brooks, D.J., Amyloid, hypometabolism, and cognition in Alzheimer disease: an [11C]PIB and [18F]FDG PET study (2007) Neurology, 68, pp. 501-508
- Elias, M.F., Beiser, A., Wolf, P.A., Au, R., White, R.F., D'Agostino, R.B., The preclinical phase of alzheimer disease: A 22-year prospective study of the Framingham Cohort (2000) Arch Neurol, 57, pp. 808-813
- Fagan, A.M., Mintun, M.A., Mach, R.H., Lee, S.Y., Dence, C.S., Shah, A.R., LaRossa, G.N., Holtzman, D.M., Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans (2006) Ann Neurol, 59 (3), pp. 512-519
- Fagan, A., Roe, C.M., Xiong, C., Mintun, M.A., Morris, J., Holtzman, D., Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults (2007) Arch Neurol, 64, pp. 343-349
- Fagan, A.M., Mintun, M.A., Shah, A.R., Aldea, P., Roe, C.M., Mach, R.H., Marcus, D., Holtzman, D.M., Cerebrospinal fluid tau and ptau(181) increase with cortical amyloid deposition in cognitively normal individuals: implications for future clinical trials of Alzheimer's disease (2009) EMBO Mol Med, 1 (8-9), pp. 371-380
- Feldman, H.H., Ferris, S., Winblad, B., Sfikas, N., Mancione, L., He, Y., Tekin, S., del Ser, T., Effect of rivastigmine on delay to diagnosis of Alzheimer's disease from mild cognitive impairment: the InDDEx study (2007) Lancet Neurol, 6, pp. 501-512
- Fellgiebel, A., Siessmeier, T., Scheurich, A., Winterer, G., Bartenstein, P., Schmidt, L.G., Möller, M.J., Association of elevated phospho-tau levels with Alzheimer-typical 18F-fluoro-2-deoxy-D-glucose positron emission tomography findings in patients with mild cognitive impairment (2004) BPS, 56, pp. 279-283
- Ferreira, L.K., Diniz, B.S., Forlenza, O.V., Busatto, G.F., Zanetti, M.V., Neurostructural predictors of Alzheimer's disease: A meta-analysis of VBM studies (2001) Neurobiol Aging, , [epub ahead of print]
- Fischer, P., Jungwirth, S., Zehetmayer, S., Weiss-gram, S., Hoenigschnabl, S., Gelpi, E., Krampla, W., Tragl, K.H., Conversion of subtypes of mild cognitive impairment to Alzheimer dementia (2007) Neurology, 68, pp. 288-291
- Fjell, A.M., Walhovd, K.B., Fennema-Notestine, C., McEvoy, L.K., Hagler, D.J., Holland, D., Blennow, K., Dale, A.M., Alzheimer's Disease Neuroimaging Initiative. Brain atrophy in healthy aging is related to CSF levels of Aβ1-42 (2010) Cereb Cortex, 20 (9), pp. 2069-2079
- Forlenza, O.V., Chiu, E., Mild cognitive impairment: a concept ready to move on? (2008) Cur Opin Psychiatry, 21, pp. 529-532
- Forlenza, O.V., Diniz, B.S., Nunes, P.V., Memoria, C.M., Yassuda, M.S., Gattaz, W.F., Diagnostic transitions in mild cognitive impairment subtypes (2009) Int Psychogeriatr, 21 (6), pp. 1088-1095
- Forlenza, O.V., Diniz, B.S., Talib, L.L., Mendonca, V.A., Ojopi, E.B., Gattaz, W.F., Teixeira, A.L., Increased serum IL-1beta level in Alzheimer's disease and mild cognitive impairment (2009) Dement Geriatr Cogn Disord, 28 (6), pp. 507-512
- Forlenza, O.V., Diniz, B.S., Talib, L.L., Radanovic, M., Yassuda, M.S., Ojopi, E.B., Gattaz, W.F., Clinical and biological predictors of Alzheimer's disease in patients with amnestic mild cognitive impairment (2010) Rev Bras Psiquiatr, 32 (3), pp. 216-222
- Forlenza, O.V., Diniz, B.S., Teixeira, A.L., Ojopi, E.B., Talib, L.L., Mendonca, V.A., Izzo, G., Gattaz, W.F., Effect of brain-derived neurotrophic factor Val66Met polymorphism and serum levels on the progression of mild cognitive impairment (2010) World J Biol Psychiatry, 11 (6), pp. 774-780
- Forlenza, O.V., Torres, C.A., Talib, L.L., de Paula, V.R., Joaquim, H.G., Diniz, B.S., Gattaz, B.S., Increased platelet GSK3B activity in patients with mild cognitive impairment and Alzheimer's disease (2010) J Psychiatr Res, 45 (2), pp. 220-224
- Forlenza, O.V., Diniz, B.S., Radanovic, M., Santos, F.S., Talib, L.L., Gattaz, W.F., Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial (2011) Br J Psychiatry, 198 (5), pp. 351-356
- Forsberg, A., Engler, H., Almkvist, O., Blomquist, G., Hagman, G., Wall, A., Ringheim, A., Nordberg, A., PET imaging of amyloid deposition in patients with mild cognitive impairment (2008) Neurobiol Aging, 29, pp. 1456-1465
- Frank, R.A., Galasko, D., Hampel, H., Hardy, J., de Leon, M.J., Mehta, P.D., Rogers, J., Trojanowski, J.Q., National Institute on Aging Biological Markers Working G. Biological markers for therapeutic trials in Alzheimer's disease. Proceedings of the biological markers working group
- NIA initiative on neuroimaging in Alzheimer's disease (2003) Neurobiol Aging, 24, pp. 521-536
- Gomez-Isla, T., Blesa, R., Boada, M., Clarimen, J., del Ser, T., Domenech, G., Ferro, J.M., Martinez-Lage, J.M., A randomized, double-blind, placebo controlled-trial of triflusal in mild cognitive impairment: the TRIMCI study (2008) Alzheimer Dis Assoc Disord, 22, pp. 21-29
- Graff-Radford, N.R., Crook, J.E., Lucas, J., Boeve, B.F., Knopman, D.S., Ivnik, R.J., Smith, G.E., Younkin, S.G., Association of low plasma Abeta42/Abeta40 ratios with increased imminent risk for mild cognitive impairment and Alzheimer disease (2007) Arch Neurol, 64 (3), pp. 354-362
- Grassi-Oliveira, R., Stein, L.M., Lopes, R.P., Teixeira, A.L., Bauer, M.E., Low plasma brain-derived neurotrophic factor and childhood physical neglect are associated with verbal memory impairment in major depression--a preliminary report (2008) Biol Psychiatry, 64, pp. 281-285
- Grassi-Oliveira, R., Brietzke, E., Pezzi, J., Lopes, R., Teixeira, A., Bauer, M., Increased soluble tumor necrosis factor-alpha receptors in patients with major depressive disorder (2009) Psychiatry Clin Neurosci, 63, pp. 202-208. , 19175760
- Hämäläinen, A., Tervo, S., Grau-Olivares, M., Niskanen, E., Pennanen, C., Huuskonen, J., Kivipelto, M., Vanhanen, M., Voxel-based morphometry to detect brain atrophy in progressive mild cognitive impairment (2007) NeuroImage, 37, pp. 1122-1131
- Hampel, H., Teipel, S.J., Fuchsberger, T., Andreasen, N., Wiltfang, J., Otto, M., Shen, Y., Farlow, M., Value of CSF beta-amyloid1-42 and tau as predictors of Alzheimer's disease in patients with mild cognitive impairment (2004) Mol Psychiatry, 9, pp. 705-710
- Hansson, O., Zetterberg, H., Buchhave, P., Londos, E., Blennow, K., Minthon, L., Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study (2006) Lancet Neurol, 5 (3), pp. 228-234
- Hansson, O., Buchhave, P., Zetterberg, H., Blennow, K., Minthon, L., Warkentin, S., Combined rCBF and CSF biomarkers predict progression from mild cognitive impairment to Alzheimer's disease (2009) Neurobiol Aging, 30, pp. 165-173
- Hansson, O., Zetterberg, H., Vanmechelen, E., Vanderstichele, H., Andreasson, U., Londos, E., Wallin, A., Blennow, K., Evaluation of plasma Abeta(40) and Abeta(42) as predictors of conversion to Alzheimer's disease in patients with mild cognitive impairment (2010) Neurobiol Aging, 31 (3), pp. 357-367
- Hashimoto, R., Hirata, Y., Asada, T., Yamashita, F., Nemoto, K., Mori, T., Moriguchi, Y., Ohnishi, T., Effect of the brain-derived neurotrophic factor and the apolipoprotein E polymorphisms on disease progression in preclinical Alzheimer's disease (2009) Genes Brain Behav, 8 (1), pp. 43-52
- Herholz, K., Salmon, E., Perani, D., Baron, J.C., Holthoff, V., Frölich, L., Schönknecht, P., Heiss, W.D., Discrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PET (2002) Neuroimage, 17 (1), pp. 302-316
- Holmes, C., Boche, D., Wilkinson, D., Yadegarfar, G., Hopkins, V., Bayer, A., Jones, R.W., Neal, J.W., Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial (2008) Lancet, 372, pp. 216-223
- Hooper, C., Killick, R., Lovestone, S., The GSK3 hypothesis of Alzheimer's disease (2008) J Neurochem, 104, pp. 1433-1439
- Hye, A., Kerr, F., Archer, N., Foy, C., Poppe, M., Brown, R., Hamilton, G., Lovestone, S., Glycogen synthase kinase-3 is increased in white cells early in Alzheimer's disease (2005) Neurosci Lett, 373, pp. 1-4
- Jack, C., Lowe, V., Weigand, S., Wiste, H., Senjem, M., Knopman, D., Shiung, M., Kemp, B., Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease (2009) Brain, 132 (5), pp. 1355-1365
- Jack, C.R., Knopman, D.S., Jagust, W.J., Shaw, L.M., Aisen, P.S., Weiner, M.W., Petersen, R.C., Trojanowski, J.Q., Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade (2010) Lancet Neurol, 9 (1), pp. 119-128
- Jefferson, A.L., Byerly, L.K., Vanderhill, S., Lambe, S., Wong, S., Ozonoff, A., Karlawish, J.H., Characterization of activities of daily living in individuals with mild cognitive impairment (2008) Am J Geriatr Psychiatry, 16 (5), pp. 375-383
- Josephs, K.A., Whitwell, J.L., Ahmed, Z., Shiung, M.M., Weigand, S.D., Knopman, D.S., Boeve, B.F., Jack Jr., C.R., Beta-amyloid burden is not associated with rates of brain atrophy (2008) Ann Neurol, 63 (2), pp. 204-212
- Jorm, A.F., Assessment of cognitive impairment and dementia using informant report (1996) Clin Psychol Rev, 16, pp. 51-73
- Jovicich, J., Czanner, S., Han, X., Salat, D., van der Kouwe, A., Quinn, B., Pacheco, J., Fischl, B., MRI-derived measurements of human subcortical, ventricular and intracranial brain volumes. Reliability effects of scan sessions, acquisition sequences, data analyses, scanner upgrade, scanner vendors and field strengths (2009) Neuroimage, 46 (1), pp. 177-192
- Kemppainen, N.M., Aalto, S., Wilson, I.A., Nagren, K., Helin, S., Brack, A., Oikonen, V., Viitanen, M., PET amyloid ligand [11C]PIB uptake is increased in mild cognitive impairment (2007) Neurology, 68, pp. 1603-1606
- Kim, K.R., Lee, K.S., Cheong, H.K., Eom, J.S., Oh, B.H., Hong, C.H., Characteristic profiles of instrumental activities of daily living in different subtypes of mild cognitive impairment (2009) Dement Geriatr Cogn Disord, 27 (3), pp. 278-285
- Klunk, W., Engler, H., Nordberg, A., Wang, Y., Blomqvist, G., Holt, D.P., Bergström, M., Estrada, S., Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B (2004) Ann Neurol, 55, pp. 306-319
- Lewczuk, P., Beck, G., Ganslandt, O., Esselmann, H., Deisenhammer, F., Regeniter, A., Petereit, H.F., Oschmann, P., International quality control survey of neurochemical dementia diagnostics (2006) Neurosci Lett, 409, pp. 1-4
- Loewenstein, D.A., Acevedo, A., Agron, J., Duara, R., Stability of neurocognitive impairment in different subtypes of mild cognitive impairment (2007) Dement Geriatr Cogn Disord, 23, pp. 82-86
- Lopez, O.L., Kuller, L.H., Mehta, P.D., Becker, J.T., Gach, H.M., Sweet, R.A., Chang, Y.F., DeKosky, S.T., Plasma amyloid levels and the risk of AD in normal subjects in the Cardiovascular Health Study (2008) Neurology, 70 (19), pp. 1664-1671
- Maruyama, M., Arai, H., Sugita, M., Tanji, H., Higuchi, M., Okamura, N., Matsui, T., Yoshida, H., Cerebrospinal fluid amyloid beta(1-42) levels in the mild cognitive impairment stage of Alzheimer's disease (2001) Exp Neurol, 172, pp. 433-436
- Mathis, C., Wang, Y., Holt, D.P., Huang, G.F., Debnath, M.L., Klunk, W., Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents (2003) J Med Chem, 46, pp. 2740-2754
- Mattson, M.P., Pathways towards and away from Alzheimer's disease (2004) Nature, 430, pp. 631-639
- Mattsson, N., Zetterberg, H., Hansson, O., Andreasen, N., Parnetti, L., Jonsson, M., Herukka, S.K., Ewers, M., CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment (2009) JAMA, 302, pp. 385-393
- Mattsson, N., Blennow, K., Zetterberg, H., Inter-laboratory variation in cerebrospinal fluid biomarkers for Alzheimer's disease: united we stand, divided we fall (2010) Clin Chem lab Med, 48, pp. 603-607
- McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., Stadlan, E.M., Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease (1984) Neurology, 34 (7), pp. 939-944
- Mielke, R., Pietrzyk, U., Jacobs, A., Fink, G.R., Ichimiya, A., Kessler, J., Herholz, K., Heiss, W.D., HMPAO SPET and FDG PET in Alzheimer's disease and vascular dementia: comparison of perfusion and metabolic pattern (1994) Eur J Nucl Med, 21 (10), pp. 1052-1060
- Mitchell, A., Shiri-Feshki, M., Rate of progression of mild cognitive impairment to dementia - meta-analysis of 41 robust inception cohort studies (2009) Acta Psychiatr Scand, 119 (4), pp. 252-265
- Morris, J.C., Roe, C.M., Grant, E.A., Head, D., Storandt, M., Goate, A.M., Fagan, A.M., Mintun, M.A., Pittsburgh compound B imaging and prediction of progression from cognitive normality to symptomatic Alzheimer disease (2009) Arch Neurol, 66 (12), pp. 1469-1475
- Mosconi, L., Perani, D., Sorbi, S., Herholz, K., Nacmias, B., Holthoff, V., Salmon, E., Pupi, A., MCI conversion to dementia and the APOE genotype: a prediction study with FDG-PET (2004) Neurology, 63 (12), pp. 2332-2340
- Mosconi, L., Tsui, W.H., Herholz, K., Pupi, A., Drzezga, A., Lucignani, G., Reiman, E.M., de Leon, M.J., Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias (2008) J Nucl Med, 49 (3), pp. 390-398
- Mrak, R.E., Neuropathology and the Neuroinflammation Idea (2009) J Alzheimer Dis, 18 (3), pp. 473-481
- Nobili, F., Salmaso, D., Morbelli, S., Girtler, N., Piccardo, A., Brugnolo, A., Dessi, B., Pagani, M., Principal component analysis of FDG PET in amnestic MCI (2008) Eur J Nucl Med Mol Imaging, 35 (12), pp. 2191-2202
- Nordlund, A., Rolstad, S., Klang, O., Lind, K., Pedersen, M., Blennow, K., Edman, A., Wallin, A., Episodic memory and speed/attention deficits are associated with Alzheimer-typical CSF abnormalities in MCI (2008) JINS, 14, pp. 582-590
- Okello, A., Koivunen, J., Edison, P., Archer, H.A., Turkheimer, F.E., Nagren, K., Bullock, R., Brooks, D.J., Conversion of amyloid positive and negative MCI to AD over 3 years: an 11C-PIB PET study (2009) Neurology, 73, pp. 754-760
- Padovani, A., Borroni, B., Colciaghi, F., Abnormalities in the pattern of platelet amyloid precursor protein forms in patients with mild cognitive impairment and Alzheimer disease (2002) Arch Neurol, 59, pp. 71-75
- Padovani, A., Pastorino, L., Borroni, B., Pettenati, C., Cottini, E., Agosti, C., Lenzi, G.L., Di Luca, M., Amyloid precursor protein in platelets: a peripheral marker for the diagnosis of sporadic AD (2001) Neurology, 57, pp. 2243-2248
- Palmer, K., Wang, H.X., Bäckman, L., Winblad, B., Fratiglioni, L., Differential evolution of cognitive impairment in nondemented older persons: results from the Kungsholmen Project (2002) Am J Psychiatry, 159, pp. 436-442
- Parnetti, L., Lanari, A., Saggese, E., Spaccatini, C., Gallai, V., Cerebrospinal fluid biochemical markers in early detection and in differential diagnosis of dementia disorders in routine clinical practice (2003) Neurol Sci, 24, pp. 199-200
- Parnetti, L., Lanari, A., Silvestrelli, G., Saggese, E., Reboldi, P., Diagnosing prodromal Alzheimer's disease: role of CSF biochemical markers (2006) Mech Ageing Dev, 127, pp. 129-132
- Parra, M.A., Abrahams, S., Fabi, K., Logie, R., Luzzi, S., Della Sala, S., Short term memory binding deficits in Alzheimer's Disease (2009) Brain, 132, pp. 1057-1066
- Peng, S., Garzon, D.J., Marchese, M., Klein, W., Ginsberg, S.D., Francis, B.M., Mount, H.T., Fahnestock, M., Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease (2009) J Neurosci, 29, pp. 9321-9329
- Peng, S., Wuu, J., Mufson, E.J., Fahnestock, M., Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease (2005) J Neurochem, 93, pp. 1412-1421
- Pereira, F.S., Oliveira, A.M., Diniz, B.S., Forlenza, O.V., Yassuda, M.S., Cross-cultural adaptation, reliability and validity of the DAFS-R in a sample of Brazilian older adults (2010) Arch Clin Neuropsychol, 25, pp. 335-343
- Pereira, F.S., Yassuda, M.S., Oliveira, A.M., Diniz, B.S., Radanovic, M., Talib, L.L., Gattaz, W.F., Forlenza, O.V., Profiles of functional deficits in mild cognitive impairment and dementia: benefits from objective measurement (2010) J Int Neuropsychol Soc, 16, pp. 297-305
- Pereira, F.S., Yassuda, M.S., Oliveira, A.M., Forlenza, O.V., Executive dysfunction correlates with impaired functional status in older adults with varying degrees of cognitive impairment (2008) Int Psychogeriatr, 20, pp. 1104-1115
- Peres, K., Helmer, C., Amieva, H., Orgogozo, J., Rouch, I., Dartigues, J., Barberger-Gateau, P., Natural History of Decline in Instrumental Activities of Daily Living Performance over the 10 Years Preceding the Clinical Diagnosis of Dementia: A Prospective Population-Based Study (2008) J Am Geriatr Soc, 56 (1), pp. 37-44
- Petersen, R.C., Smith, G.E., Waring, S.C., Ivnik, R.J., Tangalos, E.G., Kokmen, E., Mild cognitive impairment: clinical characterization and outcome (1999) Arch Neurol, 56 (3), pp. 303-308
- Petersen, R.C., Stevens, J.C., Ganguli, M., Tangalos, E.G., Cummings, J.L., DeKosky, S.T., Practice parameter: early detection of dementia: mild cognitive impairment (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology (2001) Neurology, 56, pp. 1133-1142
- Petersen, R.C., Mild cognitive impairment as a diagnostic entity (2004) J Intern Med, 256, pp. 183-194
- Petersen, R.C., Thomas, R.G., Grundman, M., Bennett, D., Doody, R., Ferris, S., Galasko, D., Levey, A., Vitamin E and donepezil for the treatment of mild cognitive impairment (2005) New Engl J Med, 352, pp. 2379-2388
- Petersen, R.C., Knopman, D.S., MCI is a clinically useful concept (2006) Int Psychogeriatr, 18, pp. 314-394
- Petrie, E.C., Cross, D.J., Galasko, D., Schellenberg, G.D., Raskind, M.A., Peskind, E.R., Minoshima, S., Preclinical evidence of Alzheimer changes: convergent cerebrospinal fluid biomarker and fluorodeoxyglucose positron emission tomography findings (2009) Arch Neurol, 66, pp. 632-637
- Reiber, H., Dynamics of brain-derived proteins in cerebrospinal fluid (2001) Clin Chim Acta, pp. 310173-310186
- Reiman, E.M., Chen, K., Liu, X., Bandy, D., Yu, M., Lee, W., Ayutyanont, N., Langbaum, J.B., Fibrillar amyloid-beta burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease (2009) Proc Natl Acad Sci USA, 106, pp. 6820-6825
- Resnick, S.M., Sojkova, J., Zhou, Y., An, Y., Ye, W., Holt, D.P., Dannals, R.F., Ferrucci, L., Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [11C]PiB (2010) Neurology, 74, pp. 807-815
- Riemenschneider, M., Lautenschlager, N., Wagenpfeil, S., Diehl, J., Drzezga, A., Kurz, A., Cerebrospinal fluid tau and beta-amyloid 42 proteins identify Alzheimer disease in subjects with mild cognitive impairment (2002) Arch Neurol, 59, pp. 1729-1734
- Ridha, B.H., Barnes, J., Bartlett, J.W., Godbolt, A., Pepple, T., Rossor, M.N., Fox, N.C., Tracking atrophy progression in familial Alzheimer's disease: a serial MRI study (2006) Lancet Neurol, 5 (10), pp. 828-834
- Rowe, C.C., Ackerman, U., Browne, W., Mulligan, R., Pike, K.L., O'Keefe, G., Tochon-Danguy, H., Jones, G., Imaging of amyloid beta in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism (2008) Lancet Neurol, 7, pp. 129-135
- Rozzini, L., Chilovi, B.V., Conti, M., Bertoletti, E., Delrio, I., Trabucchi, M., Padovani, A., Conversion of amnestic Mild Cognitive Impairment to dementia of Alzheimer type is independent to memory deterioration (2007) Int J Geriatr Psychiatry, 22, pp. 1217-1222
- Salloway, S., Sperling, R., Gilman, S., Fox, N.C., Blennow, K., Raskind, M., Sabbagh, M., van Dyck, C.H., A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease (2009) Neurology, 73, pp. 2061-2070
- Scalzo, P., Kümmer, A., Bretas, T.L., Cardoso, F., Teixeira, A.L., Serum levels of brain-derived neurotrophic factor correlate with motor impairment in Parkinson's disease (2010) J Neurol, 257 (4), pp. 540-545
- Seo, S.W., Im, K., Lee, J.M., Kim, Y.H., Kim, S.T., Kim, S.Y., Yang, D.W., Na, D.L., Cortical thickness in single- versus multiple-domain amnestic mild cognitive impairment (2007) NeuroImage, 36, pp. 289-297
- Shaw, L., Vanderstichele, H., Knapik-Czajka, M., Clark, C., Aisen, P., Petersen, R., Blennow, K., Lewczuk, P., Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects (2009) Ann Neurol, 65 (4), pp. 403-413
- Singh, V., Chertkow, H., Lerch, J.P., Evans, A.C., Dorr, A.E., Kabani, N.J., Spatial patterns of cortical thinning in mild cognitive impairment and Alzheimer's disease (2006) Brain, 129, pp. 2885-2893
- Small, B.J., Fratiglioni, L., Viitanen, M., Winblad, B., Bäckman, L., The course of cognitive impairment in preclinical Alzheimer disease: three- and 6-year follow-up of a population-based sample (2000) Arch Neurol, 57, pp. 839-844
- Small, G.W., Kepe, V., Ercoli, L.M., Siddarth, P., Bookheimer, S.Y., Miller, K.J., Lavretsky, H., Vinters, H., PET of brain amyloid and tau in mild cognitive impairment (2006) New Engl J Med, 355, pp. 2652-2663
- Stephan, B.C., Matthews, F.E., McKeith, I.G., Bond, J., Brayne, C., Medical Research Council Cognitive Function and Aging Study. Early cognitive change in the general population: how do different definitions work? (2007) J Am Geriatr Soc, 55 (10), pp. 1534-1540
- Stomrud, E., Hansson, O., Blennow, K., Minthon, L., Londos, E., Cerebrospinal fluid biomarkers predict decline in subjective cognitive function over 3 years in healthy elderly (2007) Dement Geriatr Cogn Disord, 24 (2), pp. 118-124
- Sundelöf, J., Giedraitis, V., Irizarry, M.C., Sundström, J., Ingelsson, E., Rönnemaa, E., Arnlöv, J., Basun, H., Plasma beta amyloid and the risk of Alzheimer disease and dementia in elderly men: a prospective, population-based cohort study (2008) Arch Neurol, 65, pp. 256-263
- Sunderland, T., Linker, G., Mirza, N., Putnam, K.T., Friedman, D.L., Kimmel, L.H., Bergeson, J., Cohen, R.M., Decreased beta-amyloid1 and increased tau levels in cerebrospinal fluid of patients with Alzheimer disease (2003) JAMA, 289 (16), pp. 2094-2103
- Swerdlow, R.H., Is aging part of Alzheimer's disease, or is Alzheimer's disease part of aging? (2007) Neurobiol Aging, 28, pp. 1465-1480
- Swerdlow, R.H., Khan, S.M., The Alzheimer's disease mitochondrial cascade hypothesis: an update (2009) Exp Neurol, 218, pp. 308-315
- Tabert, M.H., Albert, S.M., Borukhova-Milov, L., Camacho, Y., Pelton, G., Liu, X., Stern, Y., Devanand, D.P., Functional deficits in patients with mild cognitive impairment: prediction of AD (2002) Neurology, 58, pp. 758-764
- Tan, Z.S., Beiser, A.S., Vasan, R.S., Roubenoff, R., Dinarello, C.A., Harris, T.B., Benjamin, E.J., Wolf, P.A., Inflammatory markers and the risk of Alzheimer disease: the Framingham Study (2007) Neurology, 68, pp. 1902-1908
- Tang, K., Hynan, L.S., Baskin, F., Rosenberg, R.N., Platelet amyloid precursor protein processing: a bio-marker for Alzheimer's disease (2006) J Neurol Sci, 240, pp. 53-58
- Tapia-Arancibia, L., Aliaga, E., Silhol, M., Arancibia, S., New insights into b