Overdose deaths involving non-BZD hypnotic/sedatives in the USA: Trends analyses
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Citações na Scopus
12
Tipo de produção
article
Data de publicação
2022
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ELSEVIER
Autores
TARDELLI, Vitor S.
BIANCO, Marina C. M.
PRAKASH, Rashmika
SEGURA, Luis E.
FIDALGO, Thiago M.
MARTINS, Silvia S.
Citação
LANCET REGIONAL HEALTH-AMERICAS, v.10, article ID 100190, 11p, 2022
Resumo
Background There is sparse knowledge on overdose deaths resulting from non-benzodiazepines and gabapentinoids usage. We examined overdose death rate across demographics categories and the overdose death trends over time. Methods Using data from the National Center for Health Statistics (USA), we identified 21,167 persons that died with an overdose ICD code as the underlying cause of death and had a T42.6/T42.7 ICD code, which include gabapentinoids and z-drugs, among their multiple causes of death. The overdose death rate was calculated per 100,000 persons for every year between 2000 and 2018. We used joinpoint regression analyses to assess trends over time. Results We identified a rise in the proportion of deaths with a T42.6/T42.7 ICD code between 2000 and 2006 (yearly change: +0.06) and between 2006 and 2015 (yearly change: +0.32). From 2000 to 2008, the proportion of deaths with any other T code rose significantly (yearly change: +3.56). Between 2008 and 2018, there was also a significant rise (yearly change: +1.31). From 2000 to 2015, the proportion of deaths with a T42.6/T42.7 ICD code with any other T code rose (yearly change: +2.58). From 2000 to 2015, the proportion of deaths with a T42.6/T42.7 ICD code with a concurrent benzodiazepine T code rose (yearly change: +1.98). From 2000 to 2005, the proportion of alcohol T codes rose non-significantly (yearly change: +0.35). Finally, the proportion of alcohol T codes fell significantly between 2008 and 2018 (yearly change: - 0.74). Interpretation Deaths due to non-benzodiazepine hypnotics and gabapentinoids increased significantly over the last two decades. Clinicians should not assume that replacing benzodiazepines and opioids with these medications necessarily lowers risk to the patient.
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Referências
- Abrahamsson T, 2017, DRUG ALCOHOL DEPEN, V174, P58, DOI 10.1016/j.drugalcdep.2017.01.013
- Agarwal SD, 2019, JAMA NETW OPEN, V2, DOI 10.1001/jamanetworkopen.2018.7399
- Agrawal R, 2021, COMMUNITY MENT HLT J, V57, P920, DOI 10.1007/s10597-020-00686-5
- Bonnet U, 2017, EUR NEUROPSYCHOPHARM, V27, P1185, DOI 10.1016/j.euroneuro.2017.08.430
- Bonnet U, 2018, PSYCHIAT DANUB, V30, P142, DOI 10.24869/psyd.2018.142
- Centers For Disease Control and Prevention, 2020, US OP DISP RAT MAPS
- Centers for Disease Control and Prevention National Center for Health Statistics, MULT CCAUS DEATH 199
- Cho JN, 2020, J GEN INTERN MED, V35, P696, DOI 10.1007/s11606-019-05545-y
- Chua KP, 2021, JAMA NETW OPEN, V4, DOI 10.1001/jamanetworkopen.2021.20353
- D'Amico M, 1999, EUR J EPIDEMIOL, V15, P141, DOI 10.1023/A:1007570405888
- Evoy KE, 2021, INT J CLIN PHARM-NET, V43, P1055, DOI 10.1007/s11096-020-01217-8
- Food and Drug Administration, 2013, FDA DRUG SAFETY COMM
- Gillis D, 2019, HELIYON, V5, DOI 10.1016/j.heliyon.2019.e02515
- Gladden RM, 2019, MMWR-MORBID MORTAL W, V68, P737, DOI 10.15585/mmwr.mm6834a2
- Goodman CW, 2017, NEW ENGL J MED, V377, P411, DOI 10.1056/NEJMp1704633
- Hedegaard Holly, 2018, Natl Vital Stat Rep, V67, P1
- Hedegaard Holly, 2017, NCHS Data Brief, P1
- Hirschtritt Matthew E, 2018, Prev Med Rep, V9, P49, DOI 10.1016/j.pmedr.2017.12.010
- Johansen ME, 2018, JAMA INTERN MED, V178, P292, DOI 10.1001/jamainternmed.2017.7856
- Jones CM, 2015, AM J PREV MED, V49, P493, DOI 10.1016/j.amepre.2015.03.040
- Jones CM, 2013, JAMA-J AM MED ASSOC, V309, P657, DOI 10.1001/jama.2013.272
- Kaufmann CN, 2017, AM J EMERG MED, V35, P1414, DOI 10.1016/j.ajem.2017.04.023
- Kaufmann CN, 2016, PHARMACOEPIDEM DR S, V25, P637, DOI 10.1002/pds.3951
- Kim HJ, 2000, STAT MED, V19, P335, DOI 10.1002/(SICI)1097-0258(20000215)19:3<335::AID-SIM336>3.3.CO;2-Q
- Kripke Daniel F, 2016, F1000Res, V5, P918, DOI 10.12688/f1000research.8729.2
- Lembke A, 2018, NEW ENGL J MED, V378, P693, DOI 10.1056/NEJMp1715050
- McCall WV, 2017, AM J PSYCHIAT, V174, P18, DOI 10.1176/appi.ajp.2016.16030336
- Molero Y, 2019, BMJ-BRIT MED J, V365, DOI 10.1136/bmj.l2147
- Orsolini L, 2021, CLIN PSYCHOPHARM NEU, V19, P367, DOI 10.9758/cpn.2021.19.2.367
- Pauly NJ, 2020, J MANAG CARE SPEC PH, V26, P246, DOI 10.18553/jmcp.2020.26.3.246
- Peckham AM, 2017, CLIN DRUG INVEST, V37, P763, DOI 10.1007/s40261-017-0530-3
- Prince MA, 2013, DRUG ALCOHOL DEPEN, V133, P433, DOI 10.1016/j.drugalcdep.2013.06.033
- Siriwardena AN, 2008, BRIT J GEN PRACT, V58, P417, DOI 10.3399/bjgp08X299290
- Siriwardena AN, 2006, BRIT J GEN PRACT, V56, P964
- Statistical Methodology and Applications Branch SRP National Cancer Institute, 2020, JOINP REGR PROGR
- Stein MD, 2020, J SUBST ABUSE TREAT, V110, P37, DOI 10.1016/j.jsat.2019.12.007
- Strickler GK, 2020, MMWR SURVEILL SUMM, V69, P1, DOI 10.15585/mmwr.ss6901a1
- Tardelli VS, 2021, ADDICT BEHAV, V112, DOI 10.1016/j.addbeh.2020.106606
- Tori ME, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.2361
- Torrance N, 2020, BRIT J ANAESTH, V125, P159, DOI 10.1016/j.bja.2020.05.017
- von Elm E, 2007, BMJ-BRIT MED J, V335, P806
- Warner Margaret, 2016, Natl Vital Stat Rep, V65, P1
- Wilson N, 2020, MMWR-MORBID MORTAL W, V69, P290, DOI 10.15585/mmwr.mm6911a4
- Wong J, 2020, JAMA-J AM MED ASSOC, V324, P2211, DOI 10.1001/jama.2020.19224
- Zeng LN, 2020, FRONT PSYCHIATRY, V11, DOI 10.3389/fpsyt.2020.577429