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https://observatorio.fm.usp.br/handle/OPI/5168
Title: | Comparison Among Clomipramine, Fluoxetine, and Placebo for the Treatment of Anxiety Disorders in Children and Adolescents |
Authors: | COSTA, Carolina Zadrozny Gouvea da; MORAIS, Rosa Magaly Campelo Borba de; ZANETTA, Dirce Maria Trevisan; TURKIEWICZ, Gizela; NETO, Francisco Lotufo; MORIKAWA, Marcia; RODRIGUES, Camila Luisi; LABBADIA, Eunice Monteiro; ASBAHR, Fernando Ramos |
Citation: | JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY, v.23, n.10, p.687-692, 2013 |
Abstract: | Objective: The purpose of this study was to test the efficacy of clomipramine and fluoxetine, controlled by placebo, and compare their action in children and adolescents with anxiety disorders. Method: Thirty subjects (ages 7-17 years), who were diagnosed with generalized anxiety disorder and/or separation anxiety disorder and/or social phobia, were submitted to a 12 week double-blind, randomized, placebo-controlled trial of clomipramine and fluoxetine. The instruments included: the Schedule for Affective Disorders and Schizophrenia, the Multidimensional Anxiety Scale for Children, the Children's Depression Inventory, the Clinical Global Impressions, and the Children's Global Assessment Scale. Results: All groups (clomipramine [n=9], fluoxetine [n=10], placebo [n=11]) showed a significant improvement after 12 weeks of treatment. There were significant differences between the fluoxetine and placebo groups in some ratings of anxiety severity and impairment. No significant differences were observed between clomipramine and placebo groups or between fluoxetine and clomipramine groups. Conclusions: Treatment with placebo showed an unusual high response rate. Clomipramine showed similar efficacy compared with fluoxetine, although it was not superior to placebo. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MPS Artigos e Materiais de Revistas Científicas - HC/ICESP Artigos e Materiais de Revistas Científicas - HC/IPq Artigos e Materiais de Revistas Científicas - LIM/23 |
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art_COSTA_Comparison_Among_Clomipramine_Fluoxetine_and_Placebo_for_the_2013.PDF | publishedVersion (English) | 202.52 kB | Adobe PDF | View/Open |
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