Sex differences in the relationship between hepatic steatosis, mood and disorders

Imagem de Miniatura
Arquivos
art_GOULART_Sex_differences_in_the_relationship_between_hepatic_steatosis_2023.PDF (458.33 KB)
Citações na Scopus
3
Tipo de produção
article
Data de publicação
2023
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
PERGAMON-ELSEVIER SCIENCE LTD
Autores
GOULART, Alessandra C.
BIANCHI, Leonardo L. T.
BISMARCHI, Danielle
MINAME, Marcio H.
LOURENCA, Ana Carolina Melillo
HENARES, Bruna B.
GARCIA, Ariane T.
ALMEIDA, Mozar S. de
MACHADO, Thiago A. O.
SYLLOS, Danielli H.
Citação
JOURNAL OF PSYCHOSOMATIC RESEARCH, v.168, article ID 111216, 8p, 2023
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Objective: To investigate the association between non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD), mental symptoms (mood, anxiety disorders and distress) by sex.Methods: This a cross-sectional study performed in working-age adults from a Health Promotion Center (primary care) in Sa similar to o Paulo, Brazil. Self-reported mental symptoms from rating scales (21-item Beck Anxiety Inventory, Patient Health Questionnaire-9, and K6 distress scale) were evaluated by hepatic steatosis (NAFLD and ALD). Logistic regression models estimated the association between hepatic steatosis subtypes and mental symptoms by Odds ratios (OR) adjusted by confounders in the total sample and sex stratified.Results: Among 7241 participants (70.5% men, median age: 45 years), the frequency of steatosis was of 30.7% (25.1% NAFLD), being higher in men than women (70.5% vs. 29.5%, p < 0.0001), regardless of the steatosis subtype. Metabolic risk factors were similar in both subtypes of steatosis, but not mental symptoms. Overall, NAFLD was inversely associated with anxiety (OR = 0.75, 95%CI 0.63-0.90) and positively associated with depression (OR = 1.17, 95%CI 1.00-1.38). On the other hand, ALD was positively associated with anxiety (OR = 1.51; 95%CI 1.15-2.00). In sex-stratified analyses, only men presented an association of anxiety symptoms with NAFLD (OR = 0.73; 95%CI 0.60-0.89) and ALD (OR = 1.60; 95%CI 1.18-2.16).Conclusions: The complex association between different types of steatosis (NAFLD and ALD), mood and anxiety disorders indicates the need for a deeper understanding of their common causal pathways.
Palavras-chave
Hepatic steatosis, Mental symptoms, Primary care, Screening
URI
https://observatorio.fm.usp.br/handle/OPI/53255
Referências
  1. Beck AT, 1997, ASSESSMENT, V4, P211, DOI 10.1177/107319119700400301
  2. Beltran-Carrillo VJ, 2022, INT J QUAL STUD HEAL, V17, DOI 10.1080/17482631.2022.2056967
  3. Buzzetti E, 2017, PHARMACOL RES, V120, P97, DOI 10.1016/j.phrs.2017.03.014
  4. Callaway C.W., 1988, ANTHROPOMETRIC STAND, P41
  5. Ceylan-Isik AF, 2010, LIFE SCI, V87, P133, DOI 10.1016/j.lfs.2010.06.002
  6. Chapman LK, 2009, J ANXIETY DISORD, V23, P387, DOI 10.1016/j.janxdis.2008.12.003
  7. Cho IY, 2021, EPIDEMIOL PSYCH SCI, V30, DOI 10.1017/S204579602000116X
  8. Choi JM, 2021, FRONT MED-LAUSANNE, V7, DOI 10.3389/fmed.2020.585618
  9. Colognesi M, 2020, BIOMEDICINES, V8, DOI 10.3390/biomedicines8070229
  10. Eslam M, 2020, J HEPATOL, V73, P202, DOI 10.1016/j.jhep.2020.03.039
  11. Frojd S, 2011, ALCOHOL ALCOHOLISM, V46, P192, DOI 10.1093/alcalc/agq096
  12. Furman D, 2019, NAT MED, V25, P1822, DOI 10.1038/s41591-019-0675-0
  13. GBD 2016 Alcohol Collaborators, 2018, LANCET, V392, P1015, DOI [DOI 10.1016/S0140-6736(18)31310-2, 10.1016/S0140-6736(18)31310-2]
  14. Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
  15. Gu YP, 2022, J AFFECT DISORDERS, V301, P8, DOI 10.1016/j.jad.2021.12.128
  16. Kessler RC, 2003, ARCH GEN PSYCHIAT, V60, P184, DOI 10.1001/archpsyc.60.2.184
  17. Kiecolt-Glaser JK, 2015, AM J PSYCHIAT, V172, P1075, DOI 10.1176/appi.ajp.2015.15020152
  18. Kim D, 2019, ALIMENT PHARM THER, V50, P590, DOI 10.1111/apt.15395
  19. Kroenke K, 2001, J GEN INTERN MED, V16, P606, DOI 10.1046/j.1525-1497.2001.016009606.x
  20. Le Strat Y, 2015, LIVER INT, V35, P1910, DOI 10.1111/liv.12612
  21. Lee JW, 2021, J AFFECT DISORDERS, V278, P259, DOI 10.1016/j.jad.2020.09.073
  22. Lemyre A, 2019, AM J DRUG ALCOHOL AB, V45, P230, DOI 10.1080/00952990.2018.1536882
  23. Lima CT, 2005, ALCOHOL ALCOHOLISM, V40, P584, DOI 10.1093/alcalc/agh202
  24. Linkas J, 2022, BMC PSYCHOL, V10, DOI 10.1186/s40359-022-00779-8
  25. Lowe MR, 2006, APPETITE, V46, P16, DOI 10.1016/j.appet.2005.01.014
  26. Macavei B, 2016, EUR REV MED PHARMACO, V20, P5081
  27. Martin FPJ, 2012, NUTRIENTS, V4, P554, DOI 10.3390/nu4060554
  28. McFarlane AC, 1998, ADDICT BEHAV, V23, P813, DOI 10.1016/S0306-4603(98)00098-7
  29. Moreno-Peral P, 2014, J AFFECT DISORDERS, V168, P337, DOI 10.1016/j.jad.2014.06.021
  30. Mullish BH, 2014, ALIMENT PHARM THER, V40, P880, DOI 10.1111/apt.12925
  31. Osorio FD, 2011, INT J PSYCHIAT CLIN, V15, P255, DOI 10.3109/13651501.2011.605955
  32. Peirce JM, 2019, J NEUROSCI RES, V97, P1223, DOI 10.1002/jnr.24476
  33. Powell EE, 2021, LANCET, V397, P2212, DOI 10.1016/S0140-6736(20)32511-3
  34. Renna ME, 2018, DEPRESS ANXIETY, V35, P1081, DOI 10.1002/da.22790
  35. Santos I.S., CAD SAUDE PUBLICA
  36. Sanyal Arun J, 2002, Gastroenterology, V123, P1705, DOI 10.1053/gast.2002.36572
  37. Sayiner M, 2020, HEPATOL INT, V14, P556, DOI 10.1007/s12072-020-10038-w
  38. Scott KM, 2008, INT J OBESITY, V32, P192, DOI 10.1038/sj.ijo.0803701
  39. Sepanlou SG, 2020, LANCET GASTROENTEROL, V5, P245, DOI 10.1016/S2468-1253(19)30349-8
  40. Shaheen AA, 2021, LIVER INT, V41, P2308, DOI 10.1111/liv.14973
  41. Simon GE, 2006, ARCH GEN PSYCHIAT, V63, P824, DOI 10.1001/archpsyc.63.7.824
  42. Socci V, 2017, FRONT NUTR, V4, DOI 10.3389/fnut.2017.00019
  43. Swendsen JD, 1998, COMPR PSYCHIAT, V39, P176, DOI 10.1016/S0010-440X(98)90058-X
  44. Tovmasyan A, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0262670
  45. von Volkmann HL, 2013, MED ULTRASON, V15, P16, DOI 10.11152/mu.2013.2066.151.hlv1qmu2
  46. Williams CD, 2011, GASTROENTEROLOGY, V140, P124, DOI 10.1053/j.gastro.2010.09.038
  47. Xiao JL, 2021, FRONT MED-LAUSANNE, V8, DOI 10.3389/fmed.2021.691696
  48. Ye Q, 2020, LANCET GASTROENTEROL, V5, P739, DOI 10.1016/S2468-1253(20)30077-7
  49. Youssef NA, 2013, LIVER INT, V33, P1062, DOI 10.1111/liv.12165
  50. Zhai MM, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-84577-z

Coleções
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - LIM/23