Response to Cold Pressor Test Predicts Long-Term Changes in Pulse Wave Velocity in Men

Imagem de Miniatura
Arquivos
art_KRIEGER_Response_to_Cold_Pressor_Test_Predicts_Long_Term_2014.PDF (455.4 KB)
Citações na Scopus
8
Tipo de produção
article
Data de publicação
2014
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
OXFORD UNIV PRESS
Autores
BELLINAZZI, Vera Regina
SPOSITO, Andrei C.
SCHREIBER, Roberto
MILL, Jose G.
NADRUZ JR., Wilson
Citação
AMERICAN JOURNAL OF HYPERTENSION, v.27, n.2, p.157-161, 2014
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Aortic stiffness is associated with increased cardiovascular mortality. However, the determinants of aortic stiffness progression are not fully established. This study evaluated the predictive value of blood pressure (BP) response to cold pressor test (CPT) in the progression of carotidfemoral pulse wave velocity (PWV) in men and women. A total of 408 individuals (165 men, 243 women) from Vitoria, Brazil, underwent BP evaluation, clinical and laboratorial investigations, and CPT and PWV assessment. Five years later, the studied individuals were re-evaluated, except for the CPT. In men, 5-year PWV change correlated inversely with baseline PWV (P < 0.001) and directly with BP response to CPT (P < 0.05) and 5-year BP change (P < 0.05). In women, 5-year PWV change correlated inversely with baseline PWV (P < 0.001) and directly with age (P < 0.01), glycemia (P < 0.05) and 5-year BP change (P < 0.05) but not with BP response to CPT. Further linear regression analysis showed that 5-year PWV change was associated with baseline PWV, systolic BP response to CPT, and 5-year systolic BP change in men and with baseline PWV, age, glycemia, and 5-year systolic BP change in women. BP response to CPT was a predictor of PWV progression in men after 5 years of follow-up. These findings provide further insights into the pathophysiologic mechanisms of arterial stiffness, suggesting that elevated sympathetic reactivity may be a predisposing factor for future increases in aortic stiffness, at least in men.
Palavras-chave
blood pressure, hypertension, sex differences, sympathetic reactivity
URI
https://observatorio.fm.usp.br/handle/OPI/5359
Referências
  1. Adamopoulos D, 2009, AM J HYPERTENS, V22, P958, DOI 10.1038/ajh.2009.106
  2. Brandt MC, 2012, J AM COLL CARDIOL, V60, P1956, DOI 10.1016/j.jacc.2012.08.959
  3. Bruno Rosa M, 2012, Front Physiol, V3, P284, DOI 10.3389/fphys.2012.00284
  4. Casey DP, 2011, HYPERTENSION, V57, P421, DOI 10.1161/HYPERTENSIONAHA.110.164517
  5. Casey DP, 2012, HYPERTENSION, V59, P145, DOI 10.1161/HYPERTENSIONAHA.111.182337
  6. Cavalcante JL, 2011, J AM COLL CARDIOL, V57, P1511, DOI 10.1016/j.jacc.2010.12.017
  7. Hassellund SS, 2010, HYPERTENSION, V55, P131, DOI 10.1161/HYPERTENSIONAHA.109.143164
  8. Hering D, 2013, J HYPERTENS, V31, P1893, DOI 10.1097/HJH.0b013e3283622e58
  9. Hines EA, 1936, AM HEART J, V11, P1, DOI 10.1016/S0002-8703(36)90370-8
  10. Johansen NB, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0037165
  11. KASAGI F, 1995, HYPERTENSION, V25, P71
  12. Kneale BJ, 2000, J AM COLL CARDIOL, V36, P1233, DOI 10.1016/S0735-1097(00)00849-4
  13. Mattace-Raso FUS, 2007, J HYPERTENS, V25, P1421, DOI 10.1097/HJH.0b013e32811d6a07
  14. Santos PCJD, 2011, AM J HYPERTENS, V24, P278, DOI 10.1038/ajh.2010.244
  15. Seidlerova J, 2013, BLOOD PRESSURE, V22, P173, DOI 10.3109/08037051.2012.749578
  16. Swierblewska E, 2010, J HYPERTENS, V28, P979, DOI 10.1097/HJH.0b013e328336ed9a
  17. Utescu MS, 2013, HYPERTENSION, V62, P154, DOI 10.1161/HYPERTENSIONAHA.113.01200
  18. Vlachopoulos C, 2010, J AM COLL CARDIOL, V55, P1318, DOI 10.1016/j.jacc.2009.10.061
  19. WHO MONICA project principal investigators, 1988, J CLIN EPIDEMIOL, V41, P105
  20. Zhang MZ, 2013, AM J HYPERTENS, V26, P1132, DOI 10.1093/ajh/hpt075

Coleções
Artigos e Materiais de Revistas Científicas - FM/MCP
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/13