Indigenous people from Amazon show genetic signatures of pathogen-driven selection

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Citações na Scopus
Tipo de produção
article
Data de publicação
2023
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
AMER ASSOC ADVANCEMENT SCIENCE
Autores
COUTO-SILVA, Caina M.
NUNES, Kelly
SILVA, Marcos Araujo Castro e
V, Lygia Pereira
COMAS, David
HUNEMEIER, Tabita
Citação
SCIENCE ADVANCES, v.9, n.10, 2023
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Ecological conditions in the Amazon rainforests are historically favorable for the transmission of numerous tropical diseases, especially vector-borne diseases. The high diversity of pathogens likely contributes to the strong selective pressures for human survival and reproduction in this region. However, the genetic basis of human adaptation to this complex ecosystem remains unclear. This study investigates the possible footprints of genetic adaptation to the Amazon rainforest environment by analyzing the genomic data of 19 native populations. The results based on genomic and functional analysis showed an intense signal of natural selection in a set of genes related to Trypanosoma cruzi infection, which is the pathogen responsible for Chagas disease, a neglected tropical parasitic disease native to the Americas that is currently spreading worldwide.
Palavras-chave
URI
https://observatorio.fm.usp.br/handle/OPI/54331
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Coleções
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/13