Vitamin B6-Dependent Enzymes in the Human Malaria Parasite Plasmodium falciparum: A Druggable Target?

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art_SCHETTERT_Vitamin_B6_Dependent_Enzymes_in_the_Human_Malaria_2014.PDF (4.28 MB)
Citações na Scopus
18
Tipo de produção
article
Data de publicação
2014
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
HINDAWI PUBLISHING CORPORATION
Autores
KRONENBERGER, Thales
LINDNER, Jasmin
MEISSNER, Kamila A.
ZIMBRES, Flavia M.
CORONADO, Monika A.
SAUER, Frank M.
WRENGER, Carsten
Citação
BIOMED RESEARCH INTERNATIONAL, article ID 108516, 11p, 2014
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Malaria is a deadly infectious disease which affects millions of people each year in tropical regions. There is no effective vaccine available and the treatment is based on drugs which are currently facing an emergence of drug resistance and in this sense the search for new drug targets is indispensable. It is well established that vitamin biosynthetic pathways, such as the vitamin B6 de novo synthesis present in Plasmodium, are excellent drug targets. The active form of vitamin B6, pyridoxal 5-phosphate, is, besides its antioxidative properties, a cofactor for a variety of essential enzymes present in the malaria parasite which includes the ornithine decarboxylase (ODC, synthesis of polyamines), the aspartate aminotransferase (AspAT, involved in the protein biosynthesis), and the serine hydroxymethyltransferase (SHMT, a key enzyme within the folate metabolism).
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https://observatorio.fm.usp.br/handle/OPI/5517
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Artigos e Materiais de Revistas Científicas - LIM/13
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - ODS/03