Coronavirus disease-2019 and heart: assessment of troponin and cardiovascular comorbidities as prognostic markers in patients hospitalized with coronavirus disease-2019 in a tertiary center in Brazil

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art_PINESI_Coronavirus_disease2019_and_heart_assessment_of_troponin_and_2023.PDF (370.24 KB)
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0
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article
Data de publicação
2023
DOI
SciELO
Scopus
Web of Science
PubMed
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ASSOC MEDICA BRASILEIRA
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REVISTA DA ASSOCIACAO MEDICA BRASILEIRA, v.69, n.7, article ID e20230350, 8p, 2023
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Unidades Organizacionais
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Resumo
OBJECTIVE: Our study aimed to evaluate the correlation of cardiac troponin T levels with comorbidities and in-hospital outcomes in patients with coronavirus disease-2019 in Brazil.METHODS: Data from a cohort of 3,596 patients who were admitted with suspected coronavirus disease-2019 in a Brazilian tertiary center, between March and August 2020, were reviewed. A total of 2,441 (68%) patients had cardiac troponin T determined in the first 72 h of admission and were stratified into two groups: elevated cardiac troponin T (cardiac troponin T >0.014 ng/mL) and normal cardiac troponin T. Associations between troponin, comorbidities, biomarkers, and outcomes were assessed. Regression models were built to assess the association of several variables with in-hospital mortality.RESULTS: A total of 2,441 patients were embraced, of which 924 (38%) had normal cardiac troponin T and 1,517 (62%) had elevated cardiac troponin T. Patients with elevated cardiac troponin T were older and had more comorbidities, such as cardiovascular disease, hypertension, diabetes, arrhythmia, renal dysfunction, liver disease, stroke, cancer, and dementia. Patients with abnormal cardiac troponin T also had more altered laboratory parameters on admission (i.e., leukocytes, C-reactive protein, D-dimer, and B-type natriuretic peptide), as well as more need for intensive care unit, vasoactive drugs, mechanical ventilation, dialysis, and blood transfusion. All-cause mortality was markedly higher among patients with increased cardiac troponin T (42 vs. 16%, P<0.001). Multiple regression analysis demonstrated that in-hospital mortality was not independently associated with troponin elevation.CONCLUSION: This study showed that cardiac troponin T elevation at admission was common and associated with several comorbidities, biomarkers, and clinical outcomes in patients hospitalized with coronavirus disease-2019, but it was not an independent marker of in-hospital mortality.
Palavras-chave
COVID-19, Troponin, Cardiovascular disease, Myocardial ischemia
URI
https://observatorio.fm.usp.br/handle/OPI/56019
Referências
  1. [Anonymous], COR BRAS
  2. Bastos ML, 2020, BMJ-BRIT MED J, V370, DOI 10.1136/bmj.m2516
  3. Changal K, 2021, BMC CARDIOVASC DISOR, V21, DOI 10.1186/s12872-021-02450-3
  4. Corman VM, 2020, EUROSURVEILLANCE, V25, P23, DOI 10.2807/1560-7917.ES.2020.25.3.2000045
  5. Cunningham JW, 2021, CIRCULATION, V144, P177, DOI 10.1161/CIRCULATIONAHA.121.054969
  6. Guimaraes PO, 2021, IJC HEART VASC, V36, DOI 10.1016/j.ijcha.2021.100853
  7. Guo T, 2020, JAMA CARDIOL, V5, P811, DOI 10.1001/jamacardio.2020.1017
  8. Han H, 2020, J MED VIROL, V92, P819, DOI 10.1002/jmv.25809
  9. Huang C, 2020, LANCET, V395, P496, DOI 10.1016/S0140-6736(20)30252-X
  10. Imazio M, 2020, HEART, V106, P1127, DOI 10.1136/heartjnl-2020-317186
  11. Iorio A, 2022, AM J CARDIOL, V167, P125, DOI 10.1016/j.amjcard.2021.11.054
  12. Lala A, 2020, J AM COLL CARDIOL, V76, P533, DOI [10.1016/j.jacc.2020.06.007, 10.1101/2020.04.20.20072702]
  13. Marcilio I, 2020, CLINICS, V75, DOI 10.6061/clinics/2020/e2166
  14. Metkus TS, 2021, CIRCULATION, V143, P553, DOI 10.1161/CIRCULATIONAHA.120.050543
  15. Nasir Kansestani Atefeh, 2021, J Tehran Heart Cent, V16, P1, DOI 10.18502/jthc.v16i1.6594
  16. Omland T, 2020, CIRCULATION, V142, P1878, DOI 10.1161/CIRCULATIONAHA.120.050089
  17. Polcwiartek Christoffer, 2022, Am Heart J Plus, V14, P100131, DOI 10.1016/j.ahjo.2022.100131
  18. Sandoval Y, 2020, J AM COLL CARDIOL, V76, P1244, DOI 10.1016/j.jacc.2020.06.068
  19. Shi SB, 2020, JAMA CARDIOL, V5, P802, DOI 10.1001/jamacardio.2020.0950
  20. Torres-Torres J, 2022, VIRUSES-BASEL, V14, DOI 10.3390/v14020271
  21. von Elm E, 2008, J CLIN EPIDEMIOL, V61, P344, DOI 10.2471/BLT.07.045120
  22. Zhou F, 2020, LANCET, V395, P1054, DOI 10.1016/S0140-6736(20)30566-3

Coleções
Artigos e Materiais de Revistas Científicas - FM/MCP
Artigos e Materiais de Revistas Científicas - COVID-19
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/11
Artigos e Materiais de Revistas Científicas - LIM/13
Artigos e Materiais de Revistas Científicas - ODS/03