Multi-centre analysis of networks and genes modulated by hypothalamic stimulation in patients with aggressive behaviours

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art_GOUVEIA_Multicentre_analysis_of_networks_and_genes_modulated_by_2023.PDF (6.24 MB)
Citações na Scopus
1
Tipo de produção
article
Data de publicação
2023
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
eLIFE SCIENCES PUBL LTD
Autores
GOUVEIA, Flavia Venetucci
GERMANN, Jurgen
ELIAS, Gavin J. B.
BOUTET, Alexandre
LOH, Aaron
RIOS, Adriana Lucia Lopez
DIAZ, Cristina Torres
LOPEZ, William Omar Contreras
Citação
ELIFE, v.12, article ID e84566, 27p, 2023
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Deep brain stimulation targeting the posterior hypothalamus (pHyp-DBS) is being investigated as a treatment for refractory aggressive behavior, but its mechanisms of action remain elusive. We conducted an integrated imaging analysis of a large multi-centre dataset, incorporating volume of activated tissue modeling, probabilistic mapping, normative connectomics, and atlas-derived transcriptomics. Ninety-one percent of the patients responded positively to treatment, with a more striking improvement recorded in the pediatric population. Probabilistic mapping revealed an optimized surgical target within the posterior-inferior-lateral region of the posterior hypothalamic area. Normative connectomic analyses identified fiber tracts and functionally connected with brain areas associated with sensorimotor function, emotional regulation, and monoamine production. Functional connectivity between the target, periaqueductal gray and key limbic areas - together with patient age - were highly predictive of treatment outcome. Transcriptomic analysis showed that genes involved in mechanisms of aggressive behavior, neuronal communication, plasticity and neuroinflammation might underlie this functional network.
Palavras-chave
deep brain stimulation, hypothalamus, aggressive behaviour, imaging connectomics, imaging transcriptomics, magnetic resonance imaging, Human
URI
https://observatorio.fm.usp.br/handle/OPI/57455
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Artigos e Materiais de Revistas Científicas - FM/MNE
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - LIM/23
Artigos e Materiais de Revistas Científicas - LIM/45