Predicting Dementia Due to Alzheimer's Disease and Behavioral Variant Frontotemporal Dementia Using Algorithms with the Addenbrooke's Cognitive Examination-Revised Subscores Combined with Sociodemographic Factors

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art_AMARAL-CARVALHO_Predicting_Dementia_Due_to_Alzheimers_Disease_and_Behavioral_2023.PDF (2.01 MB)
Citações na Scopus
0
Tipo de produção
article
Data de publicação
2023
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
BENTHAM SCIENCE PUBL LTD
Autores
MARIANO, Luciano Inacio
SOUZA, Leonardo Cruz de
GUIMARAES, Henrique Cerqueira
BAHIA, Valeria Santoro
BARBOSA, Maira Tonidandel
Citação
CURRENT ALZHEIMER RESEARCH, v.20, n.5, p.341-349, 2023
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background: Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) are important causes of dementia with challenging differential diagnoses in many cases. Addenbrooke's Cognitive Examination-Revised (ACE-R) is a cognitive battery that may be useful to differentiate the two disorders.Objective: The objectibe of this study is to investigate the value of the ACE-R combined with sociodemographic factors in the differential diagnosis between AD and bvFTD.Methods The ACE-R was administered to 102 patients with mild dementia due to probable AD, 37 with mild bvFTD, and 135 controls. Performances of patients and controls were analyzed by logistic regression and by ROC curves to refine the diagnostic accuracy of the ACE-R in AD and bvFTD.Results: The ACE-R subscores Attention and Orientation, Fluency, and Memory, in combination with schooling differentiated AD from controls with an area under the ROC curve (AUC) of 0.936 (86% sensitivity and 87% specificity). The ACE-R subscores Attention and Orientation, Fluency, and Language, in combination with sex (male), age, and schooling, discriminated bvFTD from controls with an AUC of 0.908 (81% sensitivity and 95% specificity). In the differentiation between AD and bvFTD, the ACE-R subscores Attention and Orientation, Fluency, and Language, together with age, displayed an AUC of 0.865 (78% sensitivity and 85% specificity).Conclusion: The combination of ACE-R scores with sociodemographic data allowed good differentiation between AD and bvFTD in the study sample.
Palavras-chave
Cognition, dementia, frontotemporal dementia, alzheimer's disease, aging, neuropsychological tests
URI
https://observatorio.fm.usp.br/handle/OPI/57461
Referências
  1. Alexopoulos P, 2010, DEMENT GERIATR COGN, V29, P448, DOI 10.1159/000312685
  2. Amaral-Carvalho V, 2022, ARCH CLIN NEUROPSYCH, V37, P437, DOI 10.1093/arclin/acab071
  3. Amaral-Carvalho V, 2012, COGN BEHAV NEUROL, V25, P72, DOI 10.1097/WNN.0b013e318259594b
  4. [Anonymous], 1988, Dementia Rating Scale (DRS)
  5. [Anonymous], 2017, Global action plan on the public health response to dementia 2017-2025
  6. Bier JC, 2004, J NEUROL, V251, P428, DOI 10.1007/s00415-004-0345-z
  7. Brigola Allan Gustavo, 2018, Dement. neuropsychol., V12, P157, DOI 10.1590/1980-57642018dn12-020008
  8. Camozzato AL, 2008, INT PSYCHOGERIATR, V20, P383, DOI 10.1017/S1041610207006254
  9. Carvalho Viviane Amaral, 2007, Dement. neuropsychol., V1, P212, DOI 10.1590/s1980-57642008dn10200015
  10. Carvalho VA, 2010, COGN BEHAV NEUROL, V23, P8, DOI 10.1097/WNN.0b013e3181c5e2e5
  11. César KG, 2017, INT PSYCHOGERIATR, V29, P1345, DOI 10.1017/S1041610217000734
  12. Chaves MLF, 2007, ALZ DIS ASSOC DIS, V21, P210
  13. Clerc M.T., 2014, Dementia: Prevalence, P87
  14. CUMMINGS JL, 1994, NEUROLOGY, V44, P2308, DOI 10.1212/WNL.44.12.2308
  15. FAZEKAS F, 1987, AM J ROENTGENOL, V149, P351, DOI 10.2214/ajr.149.2.351
  16. Foss Maria Paula, 2013, Dement. neuropsychol., V7, P374, DOI 10.1590/S1980-57642013DN74000004
  17. Hancock P, 2009, INT PSYCHOGERIATR, V21, P526, DOI 10.1017/S1041610209008941
  18. Hergert DC, 2022, APPL NEUROPSYCH-ADUL, V29, P651, DOI 10.1080/23279095.2020.1803323
  19. Johnson JK, 2005, ARCH NEUROL-CHICAGO, V62, P925, DOI 10.1001/archneur.62.6.925
  20. Larner AJ, 2014, INT PSYCHOGERIATR, V26, P555, DOI 10.1017/S1041610213002329
  21. Lonie JA, 2010, BRIT J PSYCHIAT, V197, P135, DOI 10.1192/bjp.bp.110.077958
  22. McKhann GM, 2011, ALZHEIMERS DEMENT, V7, P263, DOI 10.1016/j.jalz.2011.03.005
  23. Miller BL, 1997, NEUROLOGY, V48, P937, DOI 10.1212/WNL.48.4.937
  24. Mioshi E, 2006, INT J GERIATR PSYCH, V21, P1078, DOI 10.1002/gps.1610
  25. Moguilner S, 2022, J NEURAL ENG, V19, DOI 10.1088/1741-2552/ac87d0
  26. Nitrini R, 2009, INT PSYCHOGERIATR, V21, P622, DOI 10.1017/S1041610209009430
  27. Rascovsky K, 2011, BRAIN, V134, P2456, DOI 10.1093/brain/awr179
  28. Seblova D, 2020, AGEING RES REV, V58, DOI 10.1016/j.arr.2019.101005
  29. Smid Jerusa, 2022, Dement. neuropsychol., V16, P1, DOI [10.1590/1980-5764-dn-2022-s101pt, 10.1590/1980-5764-DN-2022-S101PT]
  30. Tsoi KKF, 2015, JAMA INTERN MED, V175, P1450, DOI 10.1001/jamainternmed.2015.2152
  31. van Hooren SAH, 2007, AGING NEUROPSYCHOL C, V14, P40, DOI 10.1080/138255890969483

Coleções
Artigos e Materiais de Revistas Científicas - FM/MNE
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/15
Artigos e Materiais de Revistas Científicas - LIM/45