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https://observatorio.fm.usp.br/handle/OPI/57737
Title: | Sex differences in dementia risk and risk factors: Individual-participant data analysis using 21 cohorts across six continents from the COSMIC consortium |
Authors: | GONG, Jessica; HARRIS, Katie; LIPNICKI, Darren M.; CASTRO-COSTA, Erico; LIMA-COSTA, Maria Fernanda; DINIZ, Breno S.; XIAO, Shifu; LIPTON, Richard B.; KATZ, Mindy J.; WANG, Cuiling; PREUX, Pierre-Marie; GUERCHET, Maelenn; GBESSEMEHLAN, Antoine; RITCHIE, Karen; ANCELIN, Marie-Laure; SKOOG, Ingmar; NAJAR, Jenna; STERNER, Therese Rydberg; SCARMEAS, Nikolaos; YANNAKOULIA, Mary; KOSMIDIS, Mary H.; GUAITA, Antonio; ROLANDI, Elena; DAVIN, Annalisa; GUREJE, Oye; TROMPET, Stella; GUSSEKLOO, Jacobijn; RIEDEL-HELLER, Steffi; PABST, Alexander; ROHR, Susanne; SHAHAR, Suzana; SINGH, Devinder Kaur Ajit; RIVAN, Nurul Fatin Malek; BOXTEL, Martin van; KOHLER, Sebastian; GANGULI, Mary; CHANG, Chung-Chou; JACOBSEN, Erin; HAAN, Mary; DING, Ding; ZHAO, Qianhua; XIAO, Zhenxu; NARAZAKI, Kenji; CHEN, Tao; CHEN, Sanmei; NG, Tze Pin; GWEE, Xinyi; NUMBERS, Katya; MATHER, Karen A.; SCAZUFCA, Marcia; LOBO, Antonio; DE-LA-CAMARA, Concepcion; LOBO, Elena; SACHDEV, Perminder S.; BRODATY, Henry; HACKETT, Maree L.; PETERS, Sanne A. E.; WOODWARD, Mark |
Citation: | ALZHEIMERS & DEMENTIA, v.19, n.8, p.3365-3378, 2023 |
Abstract: | IntroductionSex differences in dementia risk, and risk factor (RF) associations with dementia, remain uncertain across diverse ethno-regional groups. MethodsA total of 29,850 participants (58% women) from 21 cohorts across six continents were included in an individual participant data meta-analysis. Sex-specific hazard ratios (HRs), and women-to-men ratio of hazard ratios (RHRs) for associations between RFs and all-cause dementia were derived from mixed-effect Cox models. ResultsIncident dementia occurred in 2089 (66% women) participants over 4.6 years (median). Women had higher dementia risk (HR, 1.12 [1.02, 1.23]) than men, particularly in low- and lower-middle-income economies. Associations between longer education and former alcohol use with dementia risk (RHR, 1.01 [1.00, 1.03] per year, and 0.55 [0.38, 0.79], respectively) were stronger for men than women; otherwise, there were no discernible sex differences in other RFs. DiscussionDementia risk was higher in women than men, with possible variations by country-level income settings, but most RFs appear to work similarly in women and men. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/IPq Artigos e Materiais de Revistas Científicas - LIM/23 |
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