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https://observatorio.fm.usp.br/handle/OPI/57909
Title: | Human Papillomavirus 16 Lineage A Variants Associated With Persistent Genital Infections in Men: The HPV Infection in Men (HIM) Study |
Authors: | FERREIRA, Matthew Thomas; LOPEZ, Rossana Veronica Mendoza; GONCALVES, Milena Giulia; FERREIRA, Silvaneide; SIRAK, Bradley; BAGGIO, Maria Luizai; LAZCANO-PONCE, Eduardo; NYITRAY, Alan G.; GIULIANO, Anna R.; VILLA, Luisa L.; SICHERO, Laura; LIN, Huiyi; MESSINA, Jane; CAMPBELL, Christine Pierce; GAGE, Christine; INGLES, Donna J.; ISAACS, Kim; KENNEDY, Kayoko; BOBANIC, Andrea; RAHMAN, Shams; SCHABATH, Matthew; NYITRAY, Alan; RATHWELL, Julie; PAULA, Lenice Galan de; CINTRA, Ricardo; CERNICCHIARO, Filomena; RIBEIRO, Graca; OTERO, Rosaria; BOCALON, Roberta; ANTUNES, Juliana; SILVA, Fernanda; TERRERI, Rossana; VALDEZ, Aurelio Cruz; VASQUEZ, Rene de Jesus Alvear; JUAREZ, Oscar Rojas; SOSA, Rossana del Carmen Gonzalez; VENCES, Rosangel Rios; SEGURA, Martha Huerta; GALVAN, Alicia Rodriguez; RODRIGUEZ, Paula Roman; VELEZ, Ana Laura Landa; GARCIA, Griselda Diaz; ABARCA, Veronica Chavez; QUEVEDO, Gisela Flores; NEVAREZ, Maria del Pilar Hernandez; MARTINEZ, Guillermina Sanchez; ROJAS, Adriana Ortiz; FLORES, Carlos Omar Barrera; MANGONE, Flavia Rotea; PAVANELLI, Ana Carolina |
Citation: | JOURNAL OF INFECTIOUS DISEASES, v.228, n.12, p.1748-1757, 2023 |
Abstract: | We show for the first time the influence of human papillomavirus (HPV) 16 nucleotide variability on the risk of persistent infection in the male genitalia. Our data suggest differences in the natural history of HPV-16 variants between men and women. Background Human papillomavirus (HPV) 16 non-A lineage variants have higher carcinogenic potential for cervical cancer. HPV-16 variants natural history among males is not established. We evaluated HPV-16 variants prevalence and persistence in the external genitalia of men enrolled in the prospective HPV Infection in Men (HIM) Study. Methods The HIM Study included men from the United States, Brazil, and Mexico. HPV-16 variants were distinguished using polymerase chain reaction sequencing. The prevalence of HPV-16 variants was assessed, and associations with infection persistence were estimated. Results We characterized the HPV-16 variants for 1700 genital swab samples from 753 men and 22 external genital lesions in 17 men. The prevalence of HPV-16 lineages differed by country and marital status (P < .001). Overall, 90.9% of participants harbored lineage A variants. The prevalence of non-A lineages was heterogenous among countries. HPV-16 lineage A variants were associated with a 2.69-fold increased risk of long-term persistent infections compared with non-A lineages. All high-grade penile intraepithelial neoplasia harbored lineage A variants and occurred in the context of long-term persistent infections with the same variants. Conclusions The prevalence and persistence of HPV-16 variants observed at the male external genitalia suggest differences in the natural history of these variants between men and women, which may be associated with intrinsic differences in the infected genital epithelia. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MDR Artigos e Materiais de Revistas Científicas - HC/ICESP Artigos e Materiais de Revistas Científicas - LIM/24 Artigos e Materiais de Revistas Científicas - ODS/03 |
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