Ultra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study: a mediation analysis

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Citações na Scopus
2
Tipo de produção
article
Data de publicação
2024
DOI
Scopus
Web of Science
PubMed
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Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER HEIDELBERG
Autores
MORALES-BERSTEIN, Fernanda
BIESSY, Carine
VIALLON, Vivian
GONCALVES-SOARES, Ana
CASAGRANDE, Corinne
HEMON, Bertrand
KLIEMANN, Nathalie
CAIRAT, Manon
LOPEZ, Jessica Blanco
NAHAS, Aline Al
Citação
EUROPEAN JOURNAL OF NUTRITION, v.63, n.2, p.377-396, 2024
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
PurposeTo investigate the role of adiposity in the associations between ultra-processed food (UPF) consumption and head and neck cancer (HNC) and oesophageal adenocarcinoma (OAC) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.MethodsOur study included 450,111 EPIC participants. We used Cox regressions to investigate the associations between the consumption of UPFs and HNC and OAC risk. A mediation analysis was performed to assess the role of body mass index (BMI) and waist-to-hip ratio (WHR) in these associations. In sensitivity analyses, we investigated accidental death as a negative control outcome.ResultsDuring a mean follow-up of 14.13 +/- 3.98 years, 910 and 215 participants developed HNC and OAC, respectively. A 10% g/d higher consumption of UPFs was associated with an increased risk of HNC (hazard ratio [HR] = 1.23, 95% confidence interval [CI] 1.14-1.34) and OAC (HR = 1.24, 95% CI 1.05-1.47). WHR mediated 5% (95% CI 3-10%) of the association between the consumption of UPFs and HNC risk, while BMI and WHR, respectively, mediated 13% (95% CI 6-53%) and 15% (95% CI 8-72%) of the association between the consumption of UPFs and OAC risk. UPF consumption was positively associated with accidental death in the negative control analysis.ConclusionsWe reaffirmed that higher UPF consumption is associated with greater risk of HNC and OAC in EPIC. The proportion mediated via adiposity was small. Further research is required to investigate other mechanisms that may be at play (if there is indeed any causal effect of UPF consumption on these cancers).
Palavras-chave
Epidemiology, Food processing, NOVA classification, Oesophageal cancer, Head and neck cancer, Adiposity, Mediation analysis
URI
https://observatorio.fm.usp.br/handle/OPI/59092
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Artigos e Materiais de Revistas Científicas - FM/Outros