The Risk of Reinfection or Primary Hepatitis E Virus Infection at a Liver Transplant Center in Brazil: An Observational Cohort Study

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Citações na Scopus
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Tipo de produção
article
Data de publicação
2024
DOI
Scopus
Web of Science
PubMed
Dimensions
Título da Revista
ISSN da Revista
Título do Volume
Editora
MDPI
Autores
ZICKER, Michelle
PINHO, Joao R. R.
WELTER, Eliane A. R.
GUARDIA, Bianca D.
SILVA, Paulo G. T. M. da
SILVEIRA, Leonardo B. da
Citação
VIRUSES-BASEL, v.16, n.2, article ID 301, 12p, 2024
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The hepatitis E virus is a major etiological agent of chronic hepatitis in immunosuppressed individuals. Seroprevalence in the liver transplantation setting varies according to the seroprevalence of the general population in different countries. This was a prospective cohort study of liver transplant recipients in southeastern Brazil. Recipients were systematically followed for one year, with the objective of determining the prevalence, incidence, and natural history of HEV infection in this population. We included 107 liver transplant recipients and 83 deceased donors. Positivity for anti-HEV IgG was detected in 10.2% of the recipients and in 9.7% of the donors. None of the patients tested positive for HEV RNA at baseline or during follow-up. There were no episodes of reactivation or seroconversion, even in cases of serological donor-recipient mismatch or in recipients with acute hepatitis. Acute and chronic HEV infections seem to be rare events in the region studied. That could be attributable to social, economic, and environmental factors. Our data indicate that, among liver transplant recipients, hepatitis E should be investigated only when there are elevated levels of transaminases with no defined cause, as part of the differential diagnosis of seronegative hepatitis after transplantation.
Palavras-chave
hepatitis E, liver transplantation, prevalence, incidence, natural history, Brazil
URI
https://observatorio.fm.usp.br/handle/OPI/59097
Referências
  1. Abravanel F, 2014, J INFECT DIS, V209, P1900, DOI 10.1093/infdis/jiu032
  2. Agarwala P, 2018, INDIAN J GASTROENTER, V37, P160, DOI 10.1007/s12664-018-0840-2
  3. Aslan AT, 2020, WORLD J GASTROENTERO, V26, P5543, DOI 10.3748/wjg.v26.i37.5543
  4. Baylis SA, 2011, J CLIN MICROBIOL, V49, P1234, DOI 10.1128/JCM.02578-10
  5. Pisano MB, 2017, ARCH VIROL, V162, P787, DOI 10.1007/s00705-016-3171-6
  6. Buffaz C, 2014, EUR J CLIN MICROBIOL, V33, P1037, DOI 10.1007/s10096-013-2042-2
  7. Buti M, 2010, LIVER TRANSPLANT, V16, P106, DOI 10.1002/lt.21925
  8. Chorami M, 2021, ARCH IRAN MED, V24, P22, DOI 10.34172/aim.2021.04
  9. Conte DD, 2021, BRAZ J INFECT DIS, V25, DOI 10.1016/j.bjid.2021.101655
  10. Costa MB, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-85365-5
  11. da Silva CM, 2019, INT J INFECT DIS, V86, P114, DOI 10.1016/j.ijid.2019.06.027
  12. Moraes DFDD, 2021, ANIMALS-BASEL, V11, DOI 10.3390/ani11082290
  13. Darstein F, 2020, TRANSPL P, V52, P926, DOI 10.1016/j.transproceed.2020.01.011
  14. Araújo DCDE, 2020, INT J INFECT DIS, V101, P17, DOI 10.1016/j.ijid.2020.09.024
  15. European Assoc Study Liver, 2018, J HEPATOL, V68, P1256, DOI 10.1016/j.jhep.2018.03.005
  16. Ferreira AC, 2018, ARCH VIROL, V163, P43, DOI 10.1007/s00705-017-3562-3
  17. Frias M, 2021, J CLIN MICROBIOL, V59, DOI 10.1128/JCM.02075-20
  18. Galante A, 2015, TRANSPL INFECT DIS, V17, P617, DOI 10.1111/tid.12411
  19. Gomes-Gouvêa MS, 2013, HEPATOLOGY, V58, p1052A
  20. Haagsma EB, 2009, LIVER TRANSPLANT, V15, P1225, DOI 10.1002/lt.21819
  21. Hansrivijit P, 2021, WORLD J GASTROENTERO, V27, P1240, DOI 10.3748/wjg.v27.i12.1240
  22. Hartl J, 2016, VIRUSES-BASEL, V8, DOI 10.3390/v8080211
  23. Huang WJ, 2008, J MED VIROL, V80, P824, DOI 10.1002/jmv.21140
  24. Inagaki Y, 2015, EBIOMEDICINE, V2, P1607, DOI 10.1016/j.ebiom.2015.09.030
  25. jasp-stats, JASP Software, version 0.141.0
  26. Kamar N, 2008, NEW ENGL J MED, V358, P811, DOI 10.1056/NEJMoa0706992
  27. Kamar N, 2019, CSH PERSPECT MED, V9, DOI 10.1101/cshperspect.a031872
  28. Kamar N, 2012, LANCET, V379, P2477, DOI 10.1016/S0140-6736(11)61849-7
  29. Kamar N, 2011, GASTROENTEROLOGY, V140, P1481, DOI 10.1053/j.gastro.2011.02.050
  30. Komolmit P, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-64551-x
  31. Koning L, 2015, BMC INFECT DIS, V15, DOI 10.1186/s12879-015-1103-9
  32. le Coutre P, 2009, GUT, V58, P699, DOI 10.1136/gut.2008.165571
  33. Lee GH, 2016, GASTROENTEROLOGY, V150, P355, DOI 10.1053/j.gastro.2015.10.048
  34. Legrand-Abravanel F, 2011, EMERG INFECT DIS, V17, P30, DOI 10.3201/eid1701.100527
  35. Li PF, 2020, LIVER INT, V40, P1516, DOI 10.1111/liv.14468
  36. dos Santos DRL, 2010, J CLIN VIROL, V47, P276, DOI 10.1016/j.jcv.2009.12.021
  37. Markakis GE, 2022, J VIRAL HEPATITIS, V29, P698, DOI 10.1111/jvh.13709
  38. Mrzljak A, 2019, REV SOC BRAS MED TRO, V52, DOI 10.1590/0037-8682-0302-2019
  39. Nicola S., 2015, Hepatology, V62, p1060A
  40. Nishizawa T, 2021, VIRUS RES, V299, DOI 10.1016/j.virusres.2021.198355
  41. Ögüt S, 2022, TURK J GASTROENTEROL, V33, P68, DOI 10.5152/tjg.2021.21071
  42. Pas SD, 2012, EMERG INFECT DIS, V18, P869, DOI 10.3201/eid1805.111712
  43. Passos AM, 2013, J MED VIROL, V85, P615, DOI 10.1002/jmv.23494
  44. Passos-Castilho AM, 2017, BRAZ J INFECT DIS, V21, P535, DOI 10.1016/j.bjid.2017.05.004
  45. Passos-Castilho AM, 2014, J CLIN MICROBIOL, V52, P4425, DOI 10.1128/JCM.02286-14
  46. de Moraes ACP, 2021, BRAZ J INFECT DIS, V25, DOI 10.1016/j.bjid.2021.101587
  47. Pischke S, 2010, LIVER TRANSPLANT, V16, P74, DOI 10.1002/lt.21958
  48. Pourbaix A, 2017, TRANSPL INFECT DIS, V19, DOI 10.1111/tid.12624
  49. Purdy MA, 2022, J GEN VIROL, V103, DOI 10.1099/jgv.0.001778
  50. Reekie I, 2018, J CLIN VIROL, V107, P1, DOI 10.1016/j.jcv.2018.07.011
  51. Riveiro-Barciela M, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0103028
  52. Salvio AL, 2018, J APPL MICROBIOL, V125, P1208, DOI 10.1111/jam.14024
  53. Samala N, 2022, J VIRAL HEPATITIS, V29, P1134, DOI 10.1111/jvh.13739
  54. Schlosser B, 2012, J HEPATOL, V56, P500, DOI 10.1016/j.jhep.2011.06.021
  55. Sherman KE, 2014, J VIRAL HEPATITIS, V21, pE74, DOI 10.1111/jvh.12233
  56. Sinakos E, 2018, EPIDEMIOL INFECT, V146, P1619, DOI [10.1017/S0950268818001887, 10.1017/s0950268818001887]
  57. de Souza AJS, 2012, COMP IMMUNOL MICROB, V35, P477, DOI 10.1016/j.cimid.2012.04.004
  58. Stroffolini T, 2015, EUR J INTERN MED, V26, P348, DOI 10.1016/j.ejim.2015.03.012
  59. Tengan FM, 2019, INFECT DIS POVERTY, V8, DOI 10.1186/s40249-018-0514-4
  60. Torre P, 2021, WORLD J GASTROENTERO, V27, DOI 10.3748/wjg.v27.i28.4603
  61. Trinta KS, 2001, MEM I OSWALDO CRUZ, V96, P25, DOI 10.1590/S0074-02762001000100004

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Artigos e Materiais de Revistas Científicas - FM/Outros