Possible molecular mechanisms soy-mediated in preventing and treating nonalcoholic fatty liver disease

Imagem de Miniatura
Arquivos
art_OLIVEIRA_Possible_molecular_mechanisms_soy_mediated_in_preventing_and_2012.PDF (148.78 KB)
Citações na Scopus
20
Tipo de produção
article
Data de publicação
2012
DOI
SciELO
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
AULA MEDICA EDICIONES
Autores
OLIVEIRA, L. P. M.
JESUS, R. P. de
FREIRE, T. O.
LYRA, A. Castro
LYRA, L. G. C.
Citação
NUTRICION HOSPITALARIA, v.27, n.4, p.991-998, 2012
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The aim of this review is to describe the molecular mechanisms of nonalcoholic fatty liver disease (NAFLD) and to present evidence regarding the mechanisms of soy-mediated therapeutic activity in preventing and treating NAFLD. NAFLD is induced by multiple metabolic pathways, including an increase in the release of fatty acids from the adipose tissue (lipolysis), insulin resistance (IR), and an increase in ""de novo"" fatty acid synthesis. Furthermore, NAFLD is correlated with a decrease in liver beta-oxidation, an increase in oxygen free radical production, and an increase in pro-inflammatory cytokine production, which leads to an increase in liver fat and, subsequently, to tissue damage. The bioactive compounds in soy can prevent and treat NAFLD by modulating lipid metabolism and regulating the expression of related transcription factors. Soy intake decreases the expression of sterol regulatory-element binding protein-1c (SREBP-1) and increases the expression of SREBP-2, which are transcription factors associated with the regulation of hepatic lipogenesis and reduction of cholesterol synthesis and absorption in the liver, respectively. Besides, interactions between soy components, such as standard amino acids, polyunsaturated fat, and the isoflavonoid-enriched fraction, are believed to improve fatty acid oxidation in the liver parenchyma by increasing the expression of peroxisome proliferator-activated receptor alpha (PPAR alpha)-regulated genes, thus decreasing lipid accumulation in the liver. Therefore, including soy-derived foods in the diet as a therapeutic tool for patients with NAFLD might improve their clinical evolution. (Nutr Hosp. 2012;27:991-998) DOI: 10.3305/nh.2012.27.4.5833
Palavras-chave
Soy, Dietary supplements, NAFLD, Stealosis
URI
https://observatorio.fm.usp.br/handle/OPI/618
Referências
  1. Adams LA, 2009, AM J GASTROENTEROL, V104, P861, DOI 10.1038/ajg.2009.67
  2. Adams LA, 2006, J CLIN GASTROENTEROL, V40, pS34
  3. Albano E, 2005, GUT, V54, P987, DOI 10.1136/gut.2004.057968
  4. Ascencio C, 2004, J NUTR, V134, P522
  5. Astley SB, 2007, GENES NUTR, V2, P11, DOI 10.1007/s12263-007-0011-z
  6. Badger TM, 2008, EXP BIOL MED, V233, P1242, DOI 10.3181/0802-RM-60
  7. Camma C, 2006, HEPATOLOGY, V43, P64, DOI 10.1002/hep.20983
  8. Chaia K, 2010, NUTR HOSP, V25, P622
  9. Chang Ji Ho, 2008, Nutr Res Pract, V2, P152, DOI 10.4162/nrp.2008.2.3.152
  10. Das K, 2010, HEPATOLOGY, V51, P1593, DOI 10.1002/hep.23567
  11. Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
  12. de Luis DA, 2010, NUTR HOSP, V25, P730, DOI 10.3305/nh.2010.25.5.4643
  13. Dentin R, 2006, DIABETES, V55, P2159, DOI 10.2337/db06-0200
  14. Donnelly KL, 2005, J CLIN INVEST, V115, P1343, DOI 10.1172/JCI200523621
  15. Eguchi Y, 2006, J GASTROENTEROL, V41, P462, DOI 10.1007/s00535-006-1790-5
  16. Ekstedt M, 2006, HEPATOLOGY, V44, P865, DOI 10.1002/hep.21327
  17. Fartoux L, 2005, GUT, V54, P1003, DOI 10.1136/gut.2004.050302
  18. Ferre P, 2007, HORM RES, V68, P72, DOI 10.1159/000100426
  19. Fon TK, 2011, J LIPIDS
  20. Gudbrandsen OA, 2006, BRIT J NUTR, V96, P249, DOI 10.1079/BJN20061837
  21. Gudbrandsen OA, 2009, NUTRITION, V25, P574, DOI 10.1016/j.nut.2008.10.020
  22. Hashimoto T, 2000, J BIOL CHEM, V275, P28918, DOI 10.1074/jbc.M910350199
  23. Jayagopal V, 2002, DIABETES CARE, V25, P1709, DOI 10.2337/diacare.25.10.1709
  24. Koek GH, 2011, CLIN CHIM ACTA, V412, P1297, DOI 10.1016/j.cca.2011.04.013
  25. Kotronen A, 2007, J CLIN ENDOCR METAB, V92, P3490, DOI 10.1210/jc.2007-0482
  26. Kotronen A, 2008, ARTERIOSCL THROM VAS, V28, P27, DOI 10.1161/ATVBAHA.107.147538
  27. Kugelmas M, 2003, HEPATOLOGY, V38, P413, DOI 10.1053/jhep.2003.50316
  28. Liu Q, 2010, LIPIDS HEALTH DIS, V9, DOI 10.1186/1476-511X-9-42
  29. Noriega-Lopez L, 2007, J BIOL CHEM, V282, P20657, DOI 10.1074/jbc.M701045200
  30. Ong JP, 2005, OBES SURG, V15, P310, DOI 10.1381/0960892053576820
  31. Pettinelli P, 2011, NUTR HOSP, V26, P441, DOI [10.1590/S0212-16112011000300003, 10.3305/nh.2011.26.3.5119]
  32. Pipe EA, 2009, J NUTR, V139, P1700, DOI 10.3945/jn.109.109595
  33. Postic C, 2008, J CLIN INVEST, V118, P829, DOI 10.1172/JCI34275
  34. Romero-Gomez M, 2006, REV ESP ENFERM DIG, V98, P605
  35. Ronis MJ, 2009, J NUTR, V139, P1431, DOI 10.3945/jn.109.107029
  36. Schreuder TCMA, 2008, WORLD J GASTROENTERO, V14, P2474, DOI 10.3748/wjg.14.2474
  37. Shapiro H, 2011, CLIN NUTR, V30, P6, DOI 10.1016/j.clnu.2010.06.001
  38. Shim Jee-Youn, 2007, Nutr Res Pract, V1, P266, DOI 10.4162/nrp.2007.1.4.266
  39. Shukla A, 2007, J NUTR BIOCHEM, V18, P313, DOI 10.1016/j.jnutbio.2006.05.007
  40. Simmen FA, 2010, J NUTR BIOCHEM, V21, P1106, DOI 10.1016/j.jnutbio.2009.09.008
  41. Stepanova M, 2010, GUT, V59, P1410, DOI 10.1136/gut.2010.213553
  42. Takahashi Y, 2008, J NUTR BIOCHEM, V19, P682, DOI 10.1016/j.jnutbio.2007.09.003
  43. Taniguchi CM, 2006, NAT REV MOL CELL BIO, V7, P85, DOI 10.1038/nrm1837
  44. Tarantino G, 2007, J GASTROEN HEPATOL, V22, P293, DOI 10.1111/j.1440-1746.2007.04824.x
  45. Tilg H, 2010, HEPATOLOGY, V52, P1836, DOI 10.1002/hep.24001
  46. Torre-Villalvazo I, 2008, J NUTR, V138, P462
  47. Tovar AR, 2005, J LIPID RES, V46, P1823, DOI 10.1194/jlr.M500067-JLR200
  48. Ustundag B, 2007, DIGEST DIS SCI, V52, P2006, DOI 10.1007/s10620-006-9251-9
  49. Vanni E, 2010, DIGEST LIVER DIS, V42, P320, DOI 10.1016/j.dld.2010.01.016
  50. Vidali M, 2008, J HEPATOL, V48, P399, DOI 10.1016/j.jhep.2007.10.011
  51. Westerbacka J, 2005, J CLIN ENDOCR METAB, V90, P2804, DOI 10.1210/jc.2004-1983
  52. Yang HY, 2011, NUTRITION, V27, P943, DOI 10.1016/j.nut.2010.09.004
  53. Yatsuji S, 2009, J GASTROEN HEPATOL, V24, P248, DOI 10.1111/j.1440-1746.2008.05640.x
  54. Yessoufou A, 2010, SWISS MED WKLY, V140, P4, DOI 10.4414/smw.2010.13071
  55. Younossi ZM, 2004, J CLIN GASTROENTEROL, V38, P705, DOI 10.1097/01.mcg.0000135372.10846.2a
  56. Younossi ZM, 2005, HEPATOLOGY, V42, P665, DOI 10.1002/hep.20838
  57. Zivkovic AM, 2007, AM J CLIN NUTR, V86, P285

Coleções
Artigos e Materiais de Revistas Científicas - FM/MGT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/07