Subtle Gray Matter Changes in Temporo-Parietal Cortex Associated with Cardiovascular Risk Factors

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art_VALLADA_Subtle_gray_matter_changes_in_Temporo-Parietal_Cortex_associated_2011.PDF (236.69 KB)
Citações na Scopus
19
Tipo de produção
article
Data de publicação
2011
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
IOS PRESS
Autores
ANDREI, Anna
Citação
JOURNAL OF ALZHEIMERS DISEASE, v.27, n.3, p.575-589, 2011
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Vascular risk factors may play an important role in the pathophysiology of Alzheimer's disease (AD). While there is consistent evidence of gray matter (GM) abnormalities in earlier stages of AD, the presence of more subtle GM changes associated with vascular risk factors in the absence of clinically significant vascular events has been scarcely investigated. This study aimed to examine GM changes in elderly subjects with cardiovascular risk factors. We predicted that the presence of cardiovascular risk would be associated with GM abnormalities involving the temporal-parietal cortices and limbic structures. We recruited 248 dementia-free subjects, age range 66-75 years, from the population-based "Sao Paulo Ageing and Health Study", classified in accordance to their Framingham Coronary Heart Disease Risk (FCHDR) score to undergo an MRI scan. We performed an overall analysis of covariance, controlled to total GM and APOE4 status, to investigate the presence of regional GM abnormalities in association with FCHDR subgroups (high-risk, medium-risk, and low-risk), and followed by post hoc t-test. We also applied a co-relational design in order to investigate the presence of linear progression of the GM vulnerability in association with cardiovascular risk factor. Voxel-based morphometry showed that the presence of cardiovascular risk factors were associated with regional GM loss involving the temporal cortices bilaterally. Those results retained statistical significance after including APOE4 as a covariate of interest. We also observed that there was a negative correlation between FCHDR scores and rGM distribution in the parietal cortex. Subclinical cerebrovascular abnormalities involving GM loss may provide an important link between cardiovascular risk factors and AD.
Palavras-chave
Alzheimer's disease, elderly, MRI, population-based, vascular risk factors
URI
https://observatorio.fm.usp.br/handle/OPI/6486
Referências
  1. Almeida JRC, 2005, BRAZ J MED BIOL RES, V38, P431, DOI 10.1590/S0100-879X2005000300014
  2. Almeida OP, 2008, AM J GERIAT PSYCHIAT, V16, P92, DOI 10.1097/JGP.0b013e318157cad2
  3. ALVES TCD, J ALZHEIMERS DIS, V20, P749
  4. Alves TCDF, 2006, NEUROL RES, V28, P579, DOI 10.1179/016164106X130416
  5. Alves TCTF, 2005, J NEUROIMAGING, V15, P150, DOI 10.1177/1051228404272880
  6. Biessels GJ, 2006, J NEUROL NEUROSUR PS, V77, P304, DOI 10.1136/jnnp.2005.069583
  7. Borch-Johnsen K, 2007, DAN MED BULL, V54, P157
  8. Brett M, 2002, NAT REV NEUROSCI, V3, P243, DOI 10.1038/nrn756
  9. Cechetto David F, 2008, Expert Rev Neurother, V8, P743, DOI 10.1586/14737175.8.5.743
  10. Chamorro A, 1996, STROKE, V27, P388
  11. Chen XH, 2006, PSYCHIAT RES-NEUROIM, V147, P105, DOI 10.1016/j.pscychresns.2006.01.009
  12. Cherbuin N, 2008, J GERONTOL A-BIOL, V63, P501
  13. Craft S, 2009, ARCH NEUROL-CHICAGO, V66, P300, DOI 10.1001/archneurol.2009.27
  14. Curiati PK, 2009, AM J NEURORADIOL, V30, P1850, DOI 10.3174/ajnr.A1727
  15. DeCarli C, 2005, NEUROBIOL AGING, V26, P491, DOI 10.1016/j.neurobiolaging.2004.05.004
  16. De Jong GI, 1999, NEUROSCIENCE, V91, P203, DOI 10.1016/S0306-4522(98)00659-9
  17. DeJong GI, 1997, ANN NY ACAD SCI, V826, P56
  18. de la Torre JC, 2000, NEUROBIOL AGING, V21, P331, DOI 10.1016/S0197-4580(00)00111-1
  19. de la Torre JC, 2008, NEURODEGENER DIS, V5, P126, DOI 10.1159/000113681
  20. de la Torre JC, 2009, INT REV NEUROBIOL, V84, P35, DOI 10.1016/S0074-7742(09)00403-6
  21. De La Torre JC, 2002, ANN NY ACAD SCI, V977, P196
  22. DELATORRE JC, 1992, BRAIN RES, V582, P186, DOI 10.1016/0006-8993(92)90132-S
  23. den Heijer T, 2003, DIABETOLOGIA, V46, P1604, DOI 10.1007/s00125-003-1235-0
  24. Elias MF, 1997, EXP AGING RES, V23, P201, DOI 10.1080/03610739708254281
  25. Eriksson SH, 2009, HUM BRAIN MAPP, V30, P3351, DOI 10.1002/hbm.20757
  26. Erkinjuntti Timo, 2009, V24, P79, DOI 10.1159/000197886
  27. Erten-Lyons D, 2009, NEUROLOGY, V72, P354, DOI 10.1212/01.wnl.0000341273.18141.64
  28. Espeseth T, 2008, NEUROBIOL AGING, V29, P329, DOI 10.1016/j.neurobiolaging.2006.10.030
  29. Espeseth T, 2006, COGN AFFECT BEHAV NE, V6, P31, DOI 10.3758/CABN.6.1.31
  30. Farkas E, 2004, BRAIN RES, V1008, P252, DOI 10.1016/j.brainres.2004.02.037
  31. Faul F, 2007, BEHAV RES METHODS, V39, P175, DOI 10.3758/BRM.41.4.1149
  32. Ferri CP, 2005, LANCET, V366, P2112
  33. Fitzpatrick AL, 2009, ARCH NEUROL-CHICAGO, V66, P336, DOI 10.1001/archneurol.2008.582
  34. Friston KJ, 1996, NEUROIMAGE, V4, P223, DOI 10.1006/nimg.1996.0074
  35. Garrido GEJ, 2002, J NEUROL NEUROSUR PS, V73, P508, DOI 10.1136/jnnp.73.5.508
  36. Giannakopoulos P, 2009, STROKE, V40, P983, DOI 10.1161/STROKEAHA.108.530337
  37. Giele JLP, 2004, STROKE, V35, P742, DOI 10.1161/01.STR.0000117572.56058.2A
  38. Glatt SJ, 2007, BIOL PSYCHIAT, V62, P282, DOI 10.1016/j.biopsych.2006.09.015
  39. Gold SM, 2007, DIABETOLOGIA, V50, P711, DOI 10.1007/s00125-007-0602-7
  40. Good CD, 2002, NEUROIMAGE, V17, P29, DOI 10.1006/nimg.2002.1202
  41. Grundy SM, 1998, CIRCULATION, V97, P1876
  42. Gudbjornsdottir S, 2009, DIABETIC MED, V26, P53, DOI 10.1111/j.1464-5491.2008.02633.x
  43. Henskens LH, 2009, J HYPERTENS, V27, P1446, DOI 10.1097/HJH.0b013e32832b5204
  44. Hiekikanen H, 2007, BRAIN INJURY, V21, P1307, DOI 10.1080/02699050701739549
  45. HONEA RA, NEUROLOGY, V74, P113
  46. Honea RA, 2009, J ALZHEIMERS DIS, V18, P553, DOI 10.3233/JAD-2009-1163
  47. Inoue Kazuo, 2007, J Stroke Cerebrovasc Dis, V16, P14, DOI 10.1016/j.jstrokecerebrovasdis.2006.08.001
  48. Inoue T, 1996, DIABETES RES CLIN PR, V31, P81, DOI 10.1016/0168-8227(96)01196-5
  49. Irie F, 2008, ARCH NEUROL-CHICAGO, V65, P89, DOI 10.1001/archneurol.2007.29
  50. Isoniemi H, 2006, NEUROLOGY, V67, P756, DOI 10.1212/01.wnl.0000234140.64954.12
  51. Ito Hirono, 2008, J Stroke Cerebrovasc Dis, V17, P35, DOI 10.1016/j.jstrokecerebrovasdis.2007.11.002
  52. Jeerakathil T, 2004, STROKE, V35, P1857, DOI 10.1161/01.STR.0000135226.53499.85
  53. Kalaria RN, 2008, LANCET NEUROL, V7, P812, DOI 10.1016/S1474-4422(08)70169-8
  54. Kannel WB, 1997, ADV INTERNAL MED, V42, P39
  55. Kappagoda CT, 2009, J CARDIOPULM REHABIL, V29, P207, DOI 10.1097/HCR.0b013e3181af6be5
  56. Kim SH, 2006, J AM COLL CARDIOL, V48, P293, DOI 10.1016/j.jacc.2006.03.043
  57. Kivipelto M, 2008, J CELL MOL MED, V12, P2762, DOI 10.1111/j.1582-4934.2008.00296.x
  58. Knopman D, 2001, NEUROLOGY, V56, P42
  59. Knopman DS, 2005, NEUROLOGY, V65, P876, DOI 10.1212/01.wnl.0000176074.09733.a8
  60. Koga H, 2009, J STROKE CEREBROVASC, V18, P32, DOI 10.1016/j.jstrokecerebrovasdis.2008.07.010
  61. Korf ESC, 2006, DIABETES CARE, V29, P2268, DOI 10.2337/dc06-0243
  62. Korf ESC, 2004, HYPERTENSION, V44, P29, DOI 10.1161/01.HYP.0000132475.32317.bb
  63. Korf ESC, 2007, DIABETIC MED, V24, P166, DOI 10.1111/j.1464-5491.2007.02049.x
  64. Kuczynski B, 2009, NEUROLOGY, V72, P738, DOI 10.1212/01.wnl.0000343005.35498.e5
  65. Kuller LH, 1998, STROKE, V29, P388
  66. Kumar A, 2008, J MAGN RESON IMAGING, V27, P14, DOI 10.1002/jmri.21224
  67. Kwon HM, 2006, STROKE, V37, P466, DOI 10.1161/01.STR.0000199081.17935.81
  68. Last D, 2007, DIABETES CARE, V30, P1193, DOI 10.2337/dc06-2052
  69. Launer LJ, 2000, NEUROBIOL AGING, V21, P49, DOI 10.1016/S0197-4580(00)00096-8
  70. Launer LJ, 2009, STROKE, V40, pS53, DOI 10.1161/STROKEAHA.108.533075
  71. Lopez OL, 2008, NEUROLOGY, V70, P1664, DOI 10.1212/01.wnl.0000306696.82017.66
  72. Luchsinger JA, 2005, NEUROLOGY, V65, P545, DOI 10.1212/01.wnl.0000172914.08967.dc
  73. MANOLIO TA, 1994, STROKE, V25, P318
  74. Massaro JM, 2004, STAT MED, V23, P351, DOI 10.1002/sim.1743
  75. Matsuda H, 2007, J NUCL MED, V48, P1289, DOI 10.2967/jnumed.106.037218
  76. Mercuro Giuseppe, 2003, Ital Heart J, V4, P363
  77. Meyer JS, 2000, ANN NY ACAD SCI, V903, P411, DOI 10.1111/j.1749-6632.2000.tb06393.x
  78. Miura K, 2009, CIRCULATION, V119, P1892, DOI 10.1161/CIRCULATIONAHA.108.823112
  79. Mosconi L, 2007, EXP GERONTOL, V42, P129, DOI 10.1016/j.exger.2006.05.016
  80. Mosconi Lisa, 2004, Expert Rev Neurother, V4, P831, DOI 10.1586/14737175.4.5.831
  81. Mueller SG, 2008, NEUROIMAGE, V42, P42, DOI 10.1016/j.neuroimage.2008.04.174
  82. Prince M, 2004, INT J GERIATR PSYCH, V19, P178, DOI 10.1002/gps.1059
  83. Prince M, 2007, BMC PUBLIC HEALTH, V7, DOI 10.1186/1471-2458-7-165
  84. Qiu Chengxuan, 2009, Dialogues Clin Neurosci, V11, P111
  85. Rafnsson SB, 2009, VASC MED, V14, P51, DOI 10.1177/1358863X08095027
  86. Rasgon NL, 2011, NEUROBIOL AGING, V32, P1942, DOI 10.1016/j.neurobiolaging.2009.12.005
  87. Raz N, 2007, ANN NY ACAD SCI, V1097, P84, DOI 10.1196/annals.1379.018
  88. Razay G, 2007, ARCH NEUROL-CHICAGO, V64, P93, DOI 10.1001/archneur.64.1.93
  89. Reiman EM, 2007, ANN NY ACAD SCI, V1097, P94, DOI 10.1196/annals.1379.011
  90. Riello R, 2005, AGING CLIN EXP RES, V17, P329
  91. Rimajova M, 2008, J ALZHEIMERS DIS, V13, P137
  92. Romero JR, 2009, STROKE, V40, P1590, DOI 10.1161/STROKEAHA.108.535245
  93. Roquer J, 2009, CEREBROVASC DIS, V27, P25, DOI 10.1159/000200439
  94. Rosendoff C, 2007, AM J GERIATR CARDIOL, V16, P143, DOI 10.1111/j.1076-7460.2007.06696.x
  95. Rutter MK, 2005, DIABETES, V54, P3252, DOI 10.2337/diabetes.54.11.3252
  96. Salat DH, 2009, NEUROIMAGE, V44, P1247, DOI 10.1016/j.neuroimage.2008.10.030
  97. Sawada H, 2000, J NEUROL NEUROSUR PS, V68, P653, DOI 10.1136/jnnp.68.5.653
  98. Scazufca M, 2008, INT PSYCHOGERIATR, V20, P394, DOI 10.1017/S1041610207005625
  99. SCAZUFCA M, 2007, INT PSYCHOGERIATR, V17, P1
  100. Scazufca M, 2008, INT J EPIDEMIOL, V37, P721, DOI 10.1093/ije/dym154
  101. Scazufca M, 2008, INT J EPIDEMIOL, V37, P879, DOI 10.1093/ije/dyn125
  102. Schuff N, 2009, BRAIN, V132, P1067, DOI 10.1093/brain/awp007
  103. Seshadri S, 2004, NEUROLOGY, V63, P1591
  104. Seshadri S, 2006, INT REV PSYCHIATR, V18, P409, DOI 10.1080/09540260600935413
  105. Sethi Ankur, 2008, Exp Clin Cardiol, V13, P113
  106. Shintani S, 1998, J NEUROL SCI, V160, P82, DOI 10.1016/S0022-510X(98)00182-8
  107. Sonnen JA, 2009, ARCH NEUROL-CHICAGO, V66, P315, DOI 10.1001/archneurol.2008.579
  108. Stuerenburg HJ, 2005, NEUROENDOCRINOL LETT, V26, P261
  109. Szekely CA, 2008, NEUROLOGY, V70, P17, DOI 10.1212/01.wnl.0000284596.95156.48
  110. Taki Y, 2008, OBESITY, V16, P119, DOI 10.1038/oby.2007.4
  111. Teipel SJ, 2009, J ALZHEIMERS DIS, V17, P571, DOI 10.3233/JAD-2009-1077
  112. Terribilli D, 2011, NEUROBIOL AGING, V32, P354, DOI 10.1016/j.neurobiolaging.2009.02.008
  113. Tiehuis AM, 2008, STROKE, V39, P1600, DOI 10.1161/STROKEAHA.107.506089
  114. Tonstad S, 2003, J CARDIOVASC RISK, V10, P129, DOI 10.1097/01.hjr.0000060836.46105.ae
  115. Uehara T, 1999, STROKE, V30, P378
  116. Using nontraditional risk factors in coronary heart disease risk assessment, 2009, ANN INTERN MED, V151, P474
  117. van der Flier WM, 2005, STROKE, V36, P2116, DOI 10.1161/01.STR.0000179092.59909.42
  118. Viswanathan A, 2009, NEUROLOGY, V72, P368, DOI 10.1212/01.wnl.0000341271.90478.8e
  119. Wessels AM, 2006, DIABETOLOGIA, V49, P2474, DOI 10.1007/s00125-006-0283-7
  120. Wilson PWF, 1998, CIRCULATION, V97, P1837
  121. Wisdom NM, 2011, NEUROBIOL AGING, V32, P63, DOI 10.1016/j.neurobiolaging.2009.02.003
  122. Xu GF, 2009, BRAIN, V132, P383, DOI 10.1093/brain/awn254
  123. Xu WL, 2009, DIABETES, V58, P71, DOI 10.2337/db08-0586
  124. Yakushev I, 2009, NEUROIMAGE, V44, P43, DOI 10.1016/j.neuroimage.2008.07.015
  125. Yang K, 2009, DIABETES EDUCATOR, V35, P770, DOI 10.1177/0145721709338528
  126. Ystad Martin A, 2009, BMC Med Imaging, V9, P17, DOI 10.1186/1471-2342-9-17
  127. Zivadinov R, 2009, NEUROLOGY, V73, P504, DOI 10.1212/WNL.0b013e3181b2a706

Coleções
Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - FM/MPR
Artigos e Materiais de Revistas Científicas - LIM/21
Artigos e Materiais de Revistas Científicas - LIM/23
Artigos e Materiais de Revistas Científicas - LIM/39