Analysis of the coverage capacity of the StreptInCor candidate vaccine against Streptococcus pyogenes

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Arquivos
art_AMICIS_Analysis_of_the_coverage_capacity_of_the_StreptInCor_2014.PDF (1.99 MB)
Citações na Scopus
29
Tipo de produção
article
Data de publicação
2014
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER SCI LTD
Autores
GOULART, Cibelly
Citação
VACCINE, v.32, n.32, p.4104-4110, 2014
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Streptococcus pyogenes is responsible for infections as pharyngitis, sepsis, necrotizing fasciitis and streptococcal toxic shock syndrome. The M protein is the major bacterial antigen and consists of both polymorphic N-terminal portion and a conserved region. In the present study, we analyzed the in vitro ability of StreptInCor a C-terminal candidate vaccine against S. pyogenes to induce antibodies to neutralize/opsonize the most common S. pyogenes strains in Sao Paulo by examining the recognition by sera from StreptInCor immunized mice. We also evaluated the presence of cross-reactive antibodies against human heart valve tissue. Anti-StreptInCor antibodies were able to neutralize/opsonize at least 5 strains, showing that immunization with StreptInCor is effective against several S. pyogenes strains and can prevent infection and subsequent sequelae without causing autoimmune reactions.
Palavras-chave
Streptococcus pyogenes, Vaccine, Rheumatic fever, Immunization coverage, Immune response
URI
https://observatorio.fm.usp.br/handle/OPI/7364
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/19
Artigos e Materiais de Revistas Científicas - LIM/58
Artigos e Materiais de Revistas Científicas - LIM/60
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