Genetic and ElectroNic medIcal records to predict oUtcomeS in Heart Failure patients (GENIUS-HF) - design and rationale
Carregando...
Citações na Scopus
7
Tipo de produção
article
Data de publicação
2014
Título da Revista
ISSN da Revista
Título do Volume
Editora
BIOMED CENTRAL LTD
Autores
BERNARDEZ-PEREIRA, Sabrina
SPINA, Joceli Mabel Rocha
SILVA, Rafael Muniz Miranda da
Citação
BMC CARDIOVASCULAR DISORDERS, v.14, article ID 32, 5p, 2014
Resumo
Background: Studies adopting electronic medical records and genomic information are becoming widespread. Through this new modality in research, it is possible to study how genetic variants influence susceptibility towards chronic conditions and can improve patient care. Our aim is to develop a biobank with 2,000 heart failure patients treated in a tertiary cardiology hospital containing electronic medical records data and biologic samples for performing genome-wide association studies for validation and development of medical decision routines aimed at helping the clinical management of patients. Methods/Design: Patients between 18 and 80 years old with heart failure diagnosis of different etiologies and left ventricular ejection fraction <= 50% in the past 2 years will be eligible for enrollment on the cohort. After consent, patients will be submitted to clinical baseline, echocardiography, cardiograph impedance and biochemical evaluation. Study data will be collected and managed using Research Electronic Data Capture tools. The follow up will take place every 6 months to assess cardiovascular outcomes ( all-cause mortality, cardiovascular mortality, hospitalization for worsening heart failure and current medication use). Initial analytical strategy will focus on the establishment of the accuracy of electronic medical records extraction protocols for main predictor factors of morbidity and mortality in heart failure. Discussion: Building a biobank with biologic samples and clinical data of 2,000 heart failure patients we will perform genome- wide association studies. By this way, we pretend to study how genetic variants influence susceptibility towards chronic conditions. Besides, it will be created a working group focused on the development and implementation of algorithms for validation and application of medical routines using the electronic medical records of the Heart Institute (InCor - HCFMUSP).
Palavras-chave
Biobank, Genome-wide association, Electronic data, Cardiovascular outcomes
Referências
- Bocchi Edimar Alcides, 2012, Arq Bras Cardiol, V98, P1, DOI 10.1590/S0066-782X2012000700001
- Bocchi EA, 2013, J AM COLL CARDIOL, V62, P949, DOI 10.1016/j.jacc.2013.06.013
- Cervo S, 2013, BMC MED ETHICS, V14, DOI 10.1186/1472-6939-14-30
- Dries DL, 2009, CIRC-CARDIOVASC GENE, V2, P540, DOI 10.1161/CIRCGENETICS.109.922898
- Harris PA, 2009, J BIOMED INFORM, V42, P377, DOI 10.1016/j.jbi.2008.08.010
- Kohane IS, 2011, NAT REV GENET, V12, P417, DOI 10.1038/nrg2999
- Marcondes-Braga FG, 2012, CHEST, V142, P457, DOI 10.1378/chest.11-2892
- McCarty CA, 2008, AM J MED GENET A, V146A, P3026, DOI 10.1002/ajmg.a.32559
- McCarty CA, 2011, BMC MED GENOMICS, V4, DOI 10.1186/1755-8794-4-13
- MCKEE PA, 1971, NEW ENGL J MED, V285, P1441, DOI 10.1056/NEJM197112232852601
- McMurray JJV, 2012, EUR HEART J, V33, P1787, DOI 10.1093/eurheartj/ehs104
- MILLER SA, 1988, NUCLEIC ACIDS RES, V16, P1215, DOI 10.1093/nar/16.3.1215
- Rainen L, 2002, CLIN CHEM, V48, P1883