Association between family history of mood disorders and clinical characteristics of bipolar disorder: Results from the Brazilian bipolar research network

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art_BERUTTI_Association_between_family_history_of_mood_disorders_and_2014.PDF (260.42 KB)
Citações na Scopus
16
Tipo de produção
article
Data de publicação
2014
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER SCIENCE BV
Autores
SCIPPA, Angela
KAPCZINSKI, Flavio
Citação
JOURNAL OF AFFECTIVE DISORDERS, v.161, p.104-108, 2014
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Objectives: To compare clinical characteristics of bipolar disorder (BD) in patients with and without a family history of mood disorders (FHMD) in a large sample from the Brazilian Research Network of Bipolar Disorders, Methods: Four-hundred eighty-eight DSM-lV BD patients participating in the Brazilian Research Network of Bipolar Disorders were included. Participants were divided between those with FHMD (n=230) and without FHMD (n=258). We compared these two groups on demographic and clinical variables and performed a logistic regression to identify which variables were most strongly associated with positive family history of mood disorders. Results: BD patients with FHMD presented with significantly higher lifetime prevalence of any anxiety disorder, obsessive-compulsive disorder, social phobia, substance abuse, and were more likely to present history of suicide attempts, family history of suicide attempts and suicide, and more psychiatric hospitalizations than BD patients without FHMD. Logistic regression showed that the variables most strongly associated with a positive FHMD were any comorbid anxiety disorder, comorbid substance abuse, and family history of suicide. Limitations: Cross-sectional study and verification of FHMD by indirect information. Conclusion: BD patients with FHMD differ from BD patients without FHMD in rates of comorbid anxiety disorder and substance abuse, number of hospitalizations and suicide attempts. As FHMD is routinely assessed in clinical practice, these findings may help to identify patients at risk for particular manifestations of BD and may point to a common, genetically determined neurobiological substrate that increases the risk of conditions such as comorbidities and suicidality in BD patients.
Palavras-chave
Bipolar disorder, Family history, Mood disorder, Comorbidity, Impulsivity
URI
https://observatorio.fm.usp.br/handle/OPI/7649
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - LIM/21
Artigos e Materiais de Revistas Científicas - ODS/03