Melanoma in Children, Adolescents, and Young Adults: A Clinical Pathological Study in a Brazilian Population

Imagem de Miniatura
Arquivos
art_SANCHEZ_Melanoma_in_Children_Adolescents_and_Young_Adults_A_2014.PDF (637.64 KB)
Citações na Scopus
8
Tipo de produção
article
Data de publicação
2014
Scopus
Web of Science
Título da Revista
ISSN da Revista
Título do Volume
Editora
LIPPINCOTT WILLIAMS & WILKINS
Autores
FRANCO, Dilcilea D. G. S.
SANGUEZA, Martin
Citação
AMERICAN JOURNAL OF DERMATOPATHOLOGY, v.36, n.8, p.620-628, 2014
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Malignant melanoma in children, adolescents, and young adults is unusual, especially before puberty. In children (age, 0-14 years), most primary lesions are thick and atypical (amelanotic, simulating pyogenic granuloma). In the population of adolescents and young adults (age, 15-39 years), melanoma is the third most common cancer, only behind lymphoma and breast cancer. Our study investigated the records of 89 patients diagnosed with cutaneous melanoma at age 0-39 years at Hospital das Cl nicas, Medical School, University of Sao Paulo between 1992 and 2002. They were divided into group A (0-14 years of age) and group B (15-39 years of age). The histopathology of all cases was reexamined. Statistical analysis of the data presented was performed, and the obtained data were compared with the literature. The frequency of melanoma in the group aged 15-39 years was higher in women, and the most affected site was the trunk. Additionally, melanomas were more frequent at an earlier age in patients with family history of melanoma (P = 0.014). Most cases were diagnosed, at histopathology, as superficial spreading melanoma. Thick nodular melanomas with Breslow values higher than 2 mm were associated with lymph node metastasis (P < 0.05). Our study revealed that melanoma in children, adolescents, and young adults may present peculiar behavior and outcome, which might reflect the genetic and yet not fully unraveled pathogenesis of this complex disease.
Palavras-chave
melanoma, children, adolescents, young adults
URI
https://observatorio.fm.usp.br/handle/OPI/8764
Referências
  1. Aldrink JH, 2009, J PEDIATR SURG, V44, P1514, DOI 10.1016/j.jpedsurg.2008.12.003
  2. Balch CM, 2009, J CLIN ONCOL, V27, P6199, DOI 10.1200/JCO.2009.23.4799
  3. Bandarchi B, 2010, DERMATOL RES PRACT, V2010, P1, DOI [DOI 10.1155/2010/583748, 10.1155/2010/583748]
  4. Bataille V, 2013, MED HYPOTHESES, V81, P846, DOI 10.1016/j.mehy.2013.05.031
  5. Bataille V, 2004, EUR J CANCER, V40, P429, DOI 10.1016/j.ejca.2003.09.030
  6. Berk DR, 2010, PEDIATR DERMATOL, V27, P244, DOI 10.1111/j.1525-1470.2009.01078.x
  7. Bleyer A, 2006, NIH PUB, V06-5767
  8. Bradford PT, 2009, ARCH DERMATOL, V145, P427, DOI 10.1001/archdermatol.2008.609
  9. Bressac-de-Paillerets B, 2002, BIOCHIMIE, V84, P67, DOI 10.1016/S0300-9084(01)01360-8
  10. Busam KJ, 2009, AM J SURG PATHOL, V33, P1386, DOI 10.1097/PAS.0b013e3181ac1927
  11. Cadili A, 2010, CAN J SURG, V53, P32
  12. Cerroni L, 2010, AM J SURG PATHOL, V34, P314, DOI 10.1097/PAS.0b013e3181cf7fa0
  13. Chang YM, 2009, INT J EPIDEMIOL, V38, P814, DOI 10.1093/ije/dyp166
  14. Cordoro KM, 2013, J AM ACAD DERMATOL, V68, P913, DOI 10.1016/j.jaad.2012.12.953
  15. Daniotti M, 2009, J INVEST DERMATOL, V129, P1759, DOI 10.1038/jid.2008.422
  16. Durbec F, 2012, BRIT J DERMATOL, V166, P727, DOI 10.1111/j.1365-2133.2011.10772.x
  17. Ferrari A, 2005, PEDIATRICS, V115, P649, DOI 10.1542/peds.2004-0471
  18. Gamba CS, 2013, JAMA DERMATOL JUN, P1
  19. Gerami P, 2013, AM J SURG PATHOL, V37, P1387, DOI 10.1097/PAS.0b013e31828fc283
  20. Gosh P, 2009, EXPERT REV DERMATOL, V4, P131
  21. Gualandri L, 2009, J EUR ACAD DERMATOL, V23, P283, DOI 10.1111/j.1468-3083.2008.03041.x
  22. Han D, 2012, ANN SURG ONCOL, V19, P3888, DOI 10.1245/s10434-012-2554-5
  23. Jhappan C, 2003, ONCOGENE, V22, P3099, DOI 10.1038/sj.onc.1206450
  24. Kirkwood JM, 2009, SEMIN ONCOL, V36, P419, DOI 10.1053/j.seminoncol.2009.07.001
  25. Lambie M, 2011, ANN PLAS SURG, V67, P85, DOI 10.1097/SAP.0b013e3181e0fcbc
  26. Lewis KG, 2008, DERMATOL SURG, V34, P152, DOI 10.1111/j.1524-4725.2007.34032.x
  27. Lohmann CM, 2002, AM J SURG PATHOL, V26, P47, DOI 10.1097/00000478-200201000-00005
  28. Ludgate MW, 2009, CANCER, V115, P631, DOI 10.1002/cncr.24047
  29. Mark PP, 2008, J INVEST DERMATOL, V128, P2905
  30. Mones JM, 2003, AM J DERMATOPATH, V25, P223, DOI 10.1097/00000372-200306000-00007
  31. Neier M, 2012, J PEDIAT HEMATOL ONC, V34, pS51, DOI 10.1097/MPH.0b013e31824e3852
  32. Pappo AS, 2003, EUR J CANCER, V39, P2651, DOI 10.1016/j.ejca.2003.06.001
  33. Paradela S, 2011, ARCH PATHOL LAB MED, V135, P307, DOI 10.1043/2009-0503-RA.1
  34. Paradela S, 2010, CANCER-AM CANCER SOC, V116, P4334, DOI 10.1002/cncr.25222
  35. Raskin L, 2011, AM J SURG PATHOL, V35, P243, DOI 10.1097/PAS.0b013e31820393ee
  36. Rouhani Panta, 2008, Cancer Control, V15, P248
  37. Strouse JJ, 2005, J CLIN ONCOL, V23, P4735, DOI 10.1200/JCO.2005.02.899
  38. Su LD, 2003, CANCER, V97, P499, DOI 10.1002/cncr.11074
  39. Thomas JM, 2008, NAT CLIN PRACT ONCOL, V5, P18, DOI 10.1038/ncponc1014
  40. Tucker MA, 1997, JAMA-J AM MED ASSOC, V277, P1439, DOI 10.1001/jama.277.18.1439
  41. Weir HK, 2011, J AM ACAD DERMATOL, V65
  42. White RL, 2011, ANN SURG ONCOL, V18, P3593, DOI 10.1245/s10434-011-1826-9

Coleções
Artigos e Materiais de Revistas Científicas - LIM/06
Artigos e Materiais de Revistas Científicas - FM/MDT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - ODS/03