Stress amplifies lung tissue mechanics, inflammation and oxidative stress induced by chronic inflammation
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Citações na Scopus
9
Tipo de produção
article
Data de publicação
2012
Título da Revista
ISSN da Revista
Título do Volume
Editora
INFORMA HEALTHCARE
Autores
VIEIRA, Rodolfo P.
LANCAS, Tatiana
Citação
EXPERIMENTAL LUNG RESEARCH, v.38, n.7, p.344-354, 2012
Resumo
Background: Mechanisms linking behavioral stress and inflammation are poorly understood, mainly in distal lung tissue. Objective: We have investigated whether the forced swim stress (FS) could modulate lung tissue mechanics, iNOS, cytokines, oxidative stress activation, eosinophilic recruitment, and remodeling in guinea pigs (GP) with chronic pulmonary inflammation. Methods: The GP were exposed to ovalbumin or saline aerosols (2x/wk/4wks, OVA, and SAL). Twenty-four hours after the 4th inhalation, the GP were submitted to the FS protocol (5x/wk/2wks, SAL-S, and OVA-S). Seventy-two hours after the 7th inhalation, lung strips were cut and tissue resistance (Rt) and elastance (Et) were obtained (at baseline and after OVA and Ach challenge). Strips were submitted to histopathological evaluation. Results: The adrenals' weight, the serum cortisol, and the catecholamines were measured. There was an increase in IL-2, IL-5, IL-13, IFN-gamma, iNOS, 8-iso-PGF2 alpha, and in %Rt and %Et after Ach challenge in the SAL-S group compared to the SAL one. The OVA-S group has had an increase in %Rt and %Et after the OVA challenge, in %Et after the Ach and in IL-4, 8-iso-PGF2 alpha, and actin compared to the OVA. Adrenal weight and cortisol serum were increased in stressed animals compared to nonstressed ones, and the catecholamines were unaltered. Conclusion & clinical relevance: Repeated stress has increased distal lung constriction, which was associated with an increase of actin, IL-4, and 8-iso-PGF2 alpha levels. Stress has also induced an activation of iNOS, cytokines, and oxidative stress pathways.
Palavras-chave
cytokines, iNOS, isoprostane, lung distal tissue mechanics, stress
Referências
- Angeli P, 2008, AM J PHYSIOL-LUNG C, V294, pL1197, DOI 10.1152/ajplung.00199.2007
- Bailey MT, 2009, J IMMUNOL, V182, P7888, DOI 10.4049/jimmunol.0800891
- BOULOUX P, 1985, ANN CLIN BIOCHEM, V22, P194
- Briest W, 2003, CARDIOVASC RES, V57, P379, DOI 10.1016/S0008-6363(02)00700-9
- Capelozzi MA, 2007, RESP PHYSIOL NEUROBI, V156, P171, DOI 10.1016/j.resp.2006.09.004
- Chakir J, 2003, J ALLERGY CLIN IMMUN, V111, P1293, DOI 10.1067/mai.2003.1557
- Chen E, 2007, BRAIN BEHAV IMMUN, V21, P993, DOI 10.1016/j.bbi.2007.03.009
- Chi DS, 2003, NITRIC OXIDE-BIOL CH, V8, P127, DOI 10.1016/S1089-8603(02)00148-9
- Fenske M, 1996, J EXP ANIM SCI, V38, P13
- Fernandes Lynette B, 2007, Ther Adv Respir Dis, V1, P25, DOI 10.1177/1753465807080740
- Forsythe P, 2004, AM J RESP CRIT CARE, V169, P220, DOI 10.1164/rccm.200307-979OC
- Haddad JJ, 2002, J NEUROIMMUNOL, V133, P1, DOI 10.1016/S0165-5728(02)00357-0
- Lancas T, 2006, J APPL PHYSIOL, V100, P1610, DOI 10.1152/japplphysiol.00828.2005
- Machida K, 2005, AM J PHYSIOL-LUNG C, V288, pL860, DOI 10.1152/ajplung.00131.2004
- Mauad T, 2004, AM J RESP CRIT CARE, V170, P857, DOI 10.1164/rccm.200403-305OC
- Miller M, 2006, AM J PHYSIOL-LUNG C, V290, pL162, DOI 10.1152/ajplung.00252.2005
- Nittoh T, 1998, EUR J PHARMACOL, V354, P73, DOI 10.1016/S0014-2999(98)00426-9
- Okuyama Kaori, 2007, Allergol Int, V56, P29, DOI 10.2332/allergolint.O-06-435
- Portela CD, 2002, AM J PHYSIOL-LUNG C, V282, pL1289, DOI 10.1152/ajplung.00352.2001
- Prado CM, 2006, AM J RESP CELL MOL, V35, P457, DOI 10.1165/rcmb.2005-0391OC
- Sivonova M, 2004, STRESS, V7, P183, DOI 10.1080/10253890400012685
- Starling CM, 2009, RESP PHYSIOL NEUROBI, V165, P185, DOI 10.1016/j.resp.2008.11.011
- Tiberio Iolanda F. L. C., 2003, Experimental Lung Research, V29, P165, DOI 10.1080/01902140303772
- Torres RL, 2004, BRAZ J MED BIOL RES, V37, P185
- Tulic MK, 2003, CHEST, V123, p348S, DOI 10.1378/chest.123.3_suppl.348S
- Vieira RP, 2007, AM J RESP CELL MOL, V37, P660, DOI 10.1165/rcmb.2007-01080C
- Vig RS, 2006, ANN NY ACAD SCI, V1088, P65, DOI 10.1196/annals.1366.023
- Viveros-Paredes JM, 2006, INT IMMUNOPHARMACOL, V6, P774, DOI 10.1016/j.intimp.2005.11.011
- Wicke KM, 2007, PSYCHOPHARMACOLOGY, V195, P95, DOI 10.1007/s00213-007-0874-0
- Wright RJ, 2005, CURR OPIN ALLERGY CL, V5, P23, DOI 10.1097/00130832-200502000-00006
- Xisto DG, 2005, AM J RESP CRIT CARE, V171, P829, DOI 10.1164/rccm.200408-997OC
- Yang EV, 2006, CANCER RES, V66, P10357, DOI 10.1158/0008-5472.CAN-06-2496
- Zhang HY, 1999, AM J RESP CELL MOL, V21, P658
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Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - FM/MCM
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Artigos e Materiais de Revistas Científicas - LIM/05
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Artigos e Materiais de Revistas Científicas - LIM/05