Immunological parameters in elderly women: Correlations with aerobic power, muscle strength and mood state

Imagem de Miniatura
Arquivos
art_RASO_Immunological_parameters_in_elderly_women_Correlations_with_aerobic_2012_eng.pdf (1.26 MB)
Citações na Scopus
5
Tipo de produção
article
Data de publicação
2012
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
ACADEMIC PRESS INC ELSEVIER SCIENCE
Autores
SHEPHARD, Roy J.
Citação
BRAIN BEHAVIOR AND IMMUNITY, v.26, n.4, p.597-606, 2012
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Purpose: Our objective was to relate immunological data for healthy but sedentary elderly women to aerobic power, strength, and mood state. Methods: We measured peak aerobic power and one-repetition maximum strength along with mood (depression and fatigue), quality of life and carbohydrate intake on 42 women aged 60-77 years. Standard immunological techniques determined natural killer cell count and cytotoxic activity (NKCA), proliferative responses to phytohemaglutinin and OKT3, various lymphocyte subpopulations (CD3(+), CD3(-)CD19(+), CD56(+), CD4(+), CD8(+), CD56(dim) and CD56(bright)), and markers of activation, maturation, down-regulation and susceptibility to apoptosis (CD25(+), CD28(+), CD45RA(+), CD45RO(+), CD69(+), CD95(+), HLA-DR+). Results: Correlations of immune parameters with aerobic power and strength were very similar for absolute and relative immunological data. In the group as a whole, the only correlation with aerobic power was -0.35 (relative CD4(+)CD69(+) count), but in subjects with values <22.6 mL kg(-1) min(-1) correlations ranged from -0.57 (relative CD4(+)CD45RO(+)) to 0.92 (absolute CD56(dim)HLA-DR+). In terms of muscle strength, univariate correlation coefficients ranged from -0.34 (relative and absolute CD3(+)CD4(+)CD8(+)) to +0.48 (absolute CD3(+)HLA-DR+.) and +0.50 (absolute CD8(+)CD45RA(+)CD45RO(+)). Neither NKCA nor lymphocyte proliferation were correlated with aerobic power or muscle strength. Although mood state and quality of life can sometimes be influenced by an individual's fitness level, our multivariate analyses suggested that depression, fatigue and quality of life were more important determinants of immune profile than our fitness measures. Conclusions: Psychological changes associated with aging may have a substantial adverse effect upon the immune system, and immunological function may be enhanced more by addressing these issues than by focusing upon aerobic or resistance training.
Palavras-chave
Aerobic power, Aging, Depression, Fatigue, Immune system, Muscle strength, Quality of life
URI
https://observatorio.fm.usp.br/handle/OPI/961
Referências
  1. ANTONACI S, 1987, DIAGN CLIN IMMUNOL, V5, P55
  2. Arai Milton Hideaki, 2006, Immun Ageing, V3, P9, DOI 10.1186/1742-4933-3-9
  3. BENYEHUDA A, 1992, CANCER INVEST, V10, P525, DOI 10.3109/07357909209024815
  4. Beziat V, 2011, J IMMUNOL, V186, P6753, DOI 10.4049/jimmunol.1100330
  5. Bruunsgaard H, 2000, IMMUNOL CELL BIOL, V78, P523, DOI 10.1046/j.1440-1711.2000.00965.x
  6. Chidrawar Shivani M, 2006, Immun Ageing, V3, P10, DOI 10.1186/1742-4933-3-10
  7. CRIST DM, 1989, GERONTOLOGY, V35, P66
  8. Droppelman LF, 1971, MANUAL PROFILE MOOD
  9. FIATARONE MA, 1989, J GERONTOL, V44, pM37
  10. Flynn MG, 1999, J APPL PHYSIOL, V86, P1905
  11. Franklin BA, 2006, ACSMS GUIDELINES EXE
  12. Ginaldi L, 1999, IMMUNOL RES, V20, P109, DOI 10.1007/BF02786467
  13. Grubeck-Loebenstein B, 2009, AGING CLIN EXP RES, V21, P201
  14. James SJ, 1991, PRINCIPLES PRACTICE, P3
  15. Kapasi ZF, 2003, J GERONTOL A-BIOL, V58, P636
  16. LAPERRIERE A, 1994, MED SCI SPORT EXER, V26, P182, DOI 10.1249/00005768-199402000-00008
  17. Le Garff-Tavernier M, 2010, AGING CELL, V9, P527, DOI 10.1111/j.1474-9726.2010.00584.x
  18. Linton P.J., 1987, IMMUNOL REV, V160, P9
  19. McFarlin BK, 2004, MED SCI SPORT EXER, V36, P1876, DOI 10.1249/01.MSS.0000145465.71269.10
  20. Miyaji C, 1997, J CLIN IMMUNOL, V17, P420, DOI 10.1023/A:1027324626199
  21. NASRULLAH I, 1992, J APPL PHYSIOL, V73, P1932
  22. NIEMAN DC, 1993, MED SCI SPORT EXER, V25, P823, DOI 10.1249/00005768-199307000-00011
  23. Pawelec G, 2002, FRONT BIOSCI, V7, pD1056
  24. Raso V, 2007, MED SCI SPORT EXER, V39, P2152, DOI 10.1249/mss.0b013e318156e9fa
  25. Rea IM, 1999, EXP GERONTOL, V34, P79, DOI 10.1016/S0531-5565(98)00058-8
  26. Ross KN, 2004, MED SCI SPORT EXER, V36, pS151, DOI 10.1097/00005768-200405001-00717
  27. Ruvakina D., 1998, BLOOD, V92, P2410
  28. Shephard R.J., 1997, PHYS ACTIVITY TRAINI
  29. Shinkai S, 1998, CAN J PHYSIOL PHARM, V76, P562, DOI 10.1139/cjpp-76-5-562
  30. Simpson RJ, 2010, GERONTOLOGY, V56, P449, DOI 10.1159/000270905
  31. Simpson RJ, 2011, EXERC SPORT SCI REV, V39, P23, DOI 10.1097/JES.0b013e318201f39d
  32. Skevington SM, 2004, QUAL LIFE RES, V13, P299, DOI 10.1023/B:QURE.0000018486.91360.00
  33. Solana R, 2000, VACCINE, V18, P1613, DOI 10.1016/S0264-410X(99)00495-8
  34. Spielmann G, 2011, BRAIN BEHAV IMMUN, V25, P1521, DOI 10.1016/j.bbi.2011.07.226
  35. Strindhall J, 2007, EXP GERONTOL, V42, P753, DOI 10.1016/j.exger.2007.05.001
  36. Tabachnick B. G., 2001, USING MULTIVARIATE S
  37. Targonski PV, 2007, VACCINE, V25, P3066, DOI 10.1016/j.vaccine.2007.01.025
  38. UTSUYAMA M, 1992, MECH AGEING DEV, V63, P57, DOI 10.1016/0047-6374(92)90016-7
  39. Woods JA, 1999, MECH AGEING DEV, V109, P1, DOI 10.1016/S0047-6374(99)00014-7
  40. Yoshiuchi K, 2007, PHYSIOL BEHAV, V92, P963, DOI 10.1016/j.physbeh.2007.07.001
  41. Yosiuchi K., 2006, AM J GERIAT PSYCHIAT, V14, P62

Coleções
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - FM/MOT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/IOT
Artigos e Materiais de Revistas Científicas - LIM/03
Artigos e Materiais de Revistas Científicas - LIM/41
Carregar mais