The Extracellular Matrix of the Lateral Pharyngeal Wall in Obstructive Sleep Apnea

Imagem de Miniatura
Arquivos
art_MAUAD_The_Extracellular_Matrix_of_the_Lateral_Pharyngeal_Wall_2012_eng.pdf (4.77 MB)
Citações na Scopus
34
Tipo de produção
article
Data de publicação
2012
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
AMER ACAD SLEEP MEDICINE
Autores
DANTAS, Danielle Andrade da Silva
Citação
SLEEP, v.35, n.4, p.483-490, 2012
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Study Objectives: To compare the components of the extracellular matrix in the lateral pharyngeal muscular wall in patients with and without obstructive sleep apnea (OSA). This may help to explain the origin of the increased collapsibility of the pharynx in patients with OSA. Design: Specimens from the superior pharyngeal constrictor muscle, obtained during pharyngeal surgeries, were evaluated using histochemical and immunohistochemical analyses to determine the fractional area of collagen types I and II, elastic fibers, versican, fibronectin, and matrix metalloproteinases 1 and 2 in the endomysium. Setting: Academic tertiary center. Patiens: A total of 51 nonobese adult patients, divided into 38 patients with OSA and 13 nonsnoring control subjects without OSA. Interventions: Postintervention study performed on tissues from patients after elective surgery. Measurements and Results: Pharyngeal muscles of patients with OSA had significantly more collagen type I than pharyngeal muscles in control subjects. Collagen type I was correlated positively and independently with age. The other tested components of the extracellular matrix did not differ significantly between groups. In a logistic regression, an additive effect of both the increase of collagen type I and the increase in age with the presence of OSA was observed (odds ratio (OR), 2.06; 95% confidence interval (CI), 1.17-3.63), when compared with the effect of increased age alone (OR, 1.11; 95% CI, 1.03-1.20). Conclusion: Collagen type I in the superior pharyngeal constrictor muscle was more prevalent in patients with OSA and also increased with age. It was hypothesized that this increase could delay contractile-relaxant responses in the superior pharyngeal constrictor muscle at the expiratory-inspiratory phase transition, thus increasing pharyngeal collapsibility.
Palavras-chave
Extracellular matrix, obstructive sleep apnea, pharynx, collagen type I, pharyngeal constrictor muscle, inflammation
URI
https://observatorio.fm.usp.br/handle/OPI/967
Referências
  1. Thorpy M, 1996, SLEEP, V19, P152
  2. Boyd JH, 2004, AM J RESP CRIT CARE, V170, P541, DOI 10.1164/rccm.200308-1100OC
  3. Cahali MB, 2003, LARYNGOSCOPE, V113, P1961, DOI 10.1097/00005537-200311000-00020
  4. Cahali MB, 2004, SLEEP, V27, P942
  5. Cheng S, 2011, J BIOMECH, V44, P450, DOI 10.1016/j.jbiomech.2010.09.027
  6. CISTULLI PA, 1995, CHEST, V108, P631, DOI 10.1378/chest.108.3.631
  7. Erkilic S, 2002, J LARYNGOL OTOL, V116, P911
  8. Friberg D, 1998, AM J RESP CRIT CARE, V157, P586
  9. Gnepp DR, 2000, HUM PATHOL, V31, P813, DOI 10.1053/hupa.2000.8439
  10. Grainge CL, 2011, NEW ENGL J MED, V364, P2006, DOI 10.1056/NEJMoa1014350
  11. Haus JM, 2007, J APPL PHYSIOL, V103, P2068, DOI 10.1152/japplphysiol.00670.2007
  12. Jarvinen TAH, 2002, J MUSCLE RES CELL M, V23, P245, DOI 10.1023/A:1020904518336
  13. Kielty CM, 2002, J CELL SCI, V115, P2817
  14. Kieseier BC, 2001, BRAIN, V124, P341, DOI 10.1093/brain/124.2.341
  15. Kjaer M, 2004, PHYSIOL REV, V84, P649, DOI 10.1152/physrev.00031.2003
  16. Kovanen V, 2002, EXERC SPORT SCI REV, V30, P20, DOI 10.1097/00003677-200201000-00005
  17. Kuna ST, 1997, AM J RESP CRIT CARE, V155, P1991
  18. Kuna ST, 1997, AM J RESP CRIT CARE, V156, P874
  19. Kurosu H, 1979, Nihon Seikeigeka Gakkai Zasshi, V53, P1641
  20. LABATROBERT J, 1990, FEBS LETT, V268, P386, DOI 10.1016/0014-5793(90)81291-U
  21. Li KK, 2002, J ORAL MAXIL SURG, V60, P526, DOI 10.1053/joms.2002.31849
  22. Mackey AL, 2004, J APPL PHYSIOL, V97, P197, DOI 10.1152/japplphysiol.01174.2003
  23. MAGID A, 1985, SCIENCE, V230, P1280, DOI 10.1126/science.4071053
  24. MAYS PK, 1988, MECH AGEING DEV, V45, P203, DOI 10.1016/0047-6374(88)90002-4
  25. Montes GS, 1996, CELL BIOL INT, V20, P15, DOI 10.1006/cbir.1996.0004
  26. Morgan DL, 1999, J APPL PHYSIOL, V87, P2007
  27. Ohtsuka K, 2002, ACTA OTO-LARYNGOL, V546, P99
  28. Quilliot D, 2005, INT J OBESITY, V29, P1321, DOI 10.1038/sj.ijo.0803022
  29. SALONEN V, 1985, MUSCLE NERVE, V8, P125, DOI 10.1002/mus.880080208
  30. Sawai H, 1982, Nihon Seikeigeka Gakkai Zasshi, V56, P753
  31. SCHWAB RJ, 1995, AM J RESP CRIT CARE, V152, P1673
  32. Schwab RJ, 2006, AM J RESP CRIT CARE, V173, P453, DOI 10.1164/rccm.200412-1736OC
  33. Series F, 2004, AM J RESP CRIT CARE, V170, P1114, DOI 10.1164/rccm.200404-458OC
  34. Souza RR, 2002, BIOGERONTOLOGY, V3, P325
  35. Steier J, 2010, RESP PHYSIOL NEUROBI, V171, P54, DOI 10.1016/j.resp.2010.01.012
  36. Tsuji M, 1989, Nihon Seikeigeka Gakkai Zasshi, V63, P860
  37. WOODSON BT, 1991, LARYNGOSCOPE, V101, P1318
  38. Yaman Z, 2000, CLEFT PALATE-CRAN J, V37, P197, DOI 10.1597/1545-1569(2000)037<0197:ROTSPC>2.3.CO;2
  39. Zanotti S, 2007, MATRIX BIOL, V26, P615, DOI 10.1016/j.matbio.2007.06.004

Coleções
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/05
Artigos e Materiais de Revistas Científicas - LIM/09
Artigos e Materiais de Revistas Científicas - LIM/32