Aerobic exercise attenuates pulmonary injury induced by exposure to cigarette smoke

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Arquivos
art_BISELLI_Aerobic_exercise_attenuates_pulmonary_injury_induced_by_exposure_2012_eng.pdf (1.44 MB)
Citações na Scopus
103
Tipo de produção
article
Data de publicação
2012
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
EUROPEAN RESPIRATORY SOC JOURNALS LTD
Autores
TOLEDO, A. C.
MAGALHAES, R. M.
HIZUME, D. C.
VIEIRA, R. P.
MORIYA, H. T.
Citação
EUROPEAN RESPIRATORY JOURNAL, v.39, n.2, p.254-264, 2012
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
It has recently been suggested that regular exercise reduces lung function decline and risk of chronic obstructive pulmonary disease (COPD) among active smokers; however, the mechanisms involved in this effect remain poorly understood. The present study evaluated the effects of regular exercise training in an experimental mouse model of chronic cigarette smoke exposure. Male C57BL/6 mice were divided into four groups (control, exercise, smoke and smoke+exercise). For 24 weeks, we measured respiratory mechanics, mean linear intercept, inflammatory cells and reactive oxygen species (ROS) in bronchoalveolar lavage (BAL) fluid, collagen deposition in alveolar walls, and the expression of antioxidant enzymes, matrix metalloproteinase 9, tissue inhibitor of metalloproteinase (TIMP) 1, interleukin (IL)-10 and 8-isoprostane in alveolar walls. Exercise attenuated the decrease in pulmonary elastance (p<0.01) and the increase in mean linear intercept (p=0.003) induced by cigarette smoke exposure. Exercise substantially inhibited the increase in ROS in BAL fluid and 8-isoprostane expression in lung tissue induced by cigarette smoke. In addition, exercise significantly inhibited the decreases in IL-10, TIMP1 and CuZn superoxide dismutase induced by exposure to cigarette smoke. Exercise also increased the number of cells expressing glutathione peroxidase. Our results suggest that regular aerobic physical training of moderate intensity attenuates the development of pulmonary disease induced by cigarette smoke exposure.
Palavras-chave
Aerobic exercise, chronic obstructive pulmonary disease, cigarette smoke
URI
https://observatorio.fm.usp.br/handle/OPI/985
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HU
Artigos e Materiais de Revistas Científicas - LIM/05
Artigos e Materiais de Revistas Científicas - LIM/20