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Departamento de Patologia, Faculdade de Medicina - Docente

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Agora exibindo 1 - 7 de 7
  • bookPart
    Indications and Limitations of Fine Needle Aspiration Biopsy of Lateral Cervical Masses
    (2012) CARNEIRO, Paulo Campos; SILVA, Luiz Fernando Ferraz da
  • article 5 Citação(ões) na Scopus
    Safety and Efficacy of Low-Level Laser Therapy in Autoimmune Thyroiditis: Long-Term Follow-Up Study
    (2018) HOFLING, Danilo Bianchini; CHAVANTES, Maria Cristina; BUCHPIGUEL, Carlos Alberto; CERRI, Giovanni Guido; MARUI, Suemi; CARNEIRO, Paulo Campos; CHAMMAS, Maria Cristina
    Introduction. A randomized clinical trial (RCT) was performed to evaluate the efficacy of low-level laser therapy (LLLT) for hypothyroidism induced by chronic autoimmune thyroiditis (CAT). Objective. The objective was to assess the safety and actions of LLLT 6 years after completion of the RCT. Materials and Methods. Forty-three participants were invited to participate in this study 6 years after completion of the RCT. Twenty-five were subjected to LLLT (group L), and 18 were subjected to placebo (group P). Primary outcome measure: frequency of thyroid nodules, which were subjected to fine-needle aspiration biopsy. Secondary outcome measures: dose of levothyroxine required to treat hypothyroidism, thyroid peroxidase antibodies (anti-TPO), and anti-thyroglobulin antibodies (anti-Tg). Results. In group L, a nodule was observed in three patients, who all had a Bethesda II classification. In group P, a nodule was also observed in three patients, with two classified as Bethesda II and one as Bethesda III. The levothyroxine dose required by group L was significantly lower than that required by group P (P = 0 002). The anti-TPO and anti-Tg levels did not differ between the groups. Conclusion. LLLT, by the methods described, has been shown to be safe for the treatment of hypothyroidism resulting from CAT.
  • article 0 Citação(ões) na Scopus
    Insights concerning partial verification bias in retrospective FNAC studies Reply
    (2015) DIAZ, Katya Pulido; GERHARD, Rene; DOMINGUES, Regina Barros; MARTINS, Leandro Liporoni; RIBEIRO, Ana Carolina Prado; LOPES, Mrcio Ajudarte; CARNEIRO, Paulo Campos; VARGAS, Pablo Agustin
  • conferenceObject
    (2017) HOFLING, Danilo; CHAVANTES, M. Cristina; BUCHPIGUEL, Carlos Alberto; CERRI, Giovanni Guido; CARNEIRO, Paulo Campos; MARUI, Suemi; CHAMMAS, Maria Cristina
  • article 17 Citação(ões) na Scopus
    Malignancy rates for Bethesda III subcategories in thyroid fine needle aspiration biopsy (FNAB)
    (2018) MOSCA, Leticia; SILVA, Luiz Fernando Ferraz da; CARNEIRO, Paulo Campos; CHACON, Danielle Azevedo; ARAUJO-NETO, Vergilius Jose Furtado de; ARAUJO-FILHO, Vergilius Jose Furtado de; CERNEA, Claudio Roberto
    OBJECTIVES: Most thyroid diseases are nodular and have been investigated using ultrasound-guided fine needle aspiration biopsy (FNAB), the reports of which are standardized by the Bethesda System. Bethesda category III represents a heterogeneous group in terms of lesion characteristics and the malignancy rates reported in the literature. The objective of the present study was to evaluate the differences in the malignancy rates among Bethesda III subcategories. METHODS: Data from 1,479 patients who had thyroid surgery were reviewed. In total, 1,093 patients (89.6% female, mean age 52.7 (13-89) years) were included, and 386 patients were excluded. FNAB results (based on Bethesda Class) and histopathological results (benign or malignant) for coincident areas were collected. Bethesda III patients were subcategorized according to cytopathological characteristics (FLUS: follicular lesion of undetermined significance, Bethesda IIIA; AUS: atypia of undetermined significance, Bethesda IIIB). Data were correlated to obtain the malignancy rates for each Bethesda category and the newly defined subcategory. RESULTS: FNAB results for these patients were as follows: Bethesda I: 3.1%; Bethesda II: 18.6%; Bethesda III: 35.0%; Bethesda IV: 22.1%; Bethesda V: 4.1%; and Bethesda VI: 17.1%. The malignancy rates for Bethesda Class IIIB were significantly higher than those for Bethesda Class IIIA (p < 0.001) and Bethesda Class IV (p < 0.001). Bethesda Class IIIA showed significantly lower malignancy rates than Bethesda Class III overall (p < 0.001) CONCLUSIONS: Improvements of the Bethesda System should consider this subcategorization to better reflect different malignancy rates, which may have a significant impact on the decision-making process.
  • article 24 Citação(ões) na Scopus
    High diagnostic accuracy and reproducibility of fine-needle aspiration cytology for diagnosing salivary gland tumors: cytohistologic correlation in 182 cases
    (2014) DIAZ, Katya Pulido; GERHARD, Rene; DOMINGUES, Regina Barros; MARTINS, Leandro Liporoni; RIBEIRO, Ana Carolina Prado; LOPES, Marcio Ajudarte; CARNEIRO, Paulo Campos; VARGAS, Pablo Agustin
    Objective. The purpose of this study was to assess the efficacy and reproducibility of the cytologic diagnosis of salivary gland tumors (SGTs) using fine-needle aspiration cytology (FNAC). The study aimed to determine diagnostic accuracy, sensitivity, and specificity and to evaluate the extent of interobserver agreement. Study Design. We retrospectively evaluated SGTs from the files of the Division of Pathology at the Clinics Hospital of Sao Paulo and Piracicaba Dental School between 2000 and 2006. Results. We performed cytohistologic correlation in 182 SGTs. The sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy were 94%, 100%, 100%, 100%, and 99%, respectively. The interobserver cytologic reproducibility showed significant statistical concordance (P <.0001). Conclusions. FNAC is an effective tool for performing a reliable preoperative diagnosis in SGTs and shows high diagnostic accuracy and consistent interobserver reproducibility. Further FNAC studies analyzing large samples of malignant SGTs and reactive salivary lesions are needed to confirm their accuracy.
  • article 3 Citação(ões) na Scopus
    Incidental thyroid carcinoma: Correlation between FNAB cytology and pathological examination in 1093 cases
    (2022) RODRIGUES, Mariana Goncalves; SILVA, Luiz Fernando Ferraz da; ARAUJO-FILHO, Vergilius Jose Furtado de; MOSCA, Leticia de Moraes; ARAUJO-NETO, Vergilius Jose Furtado de; KOWALSKI, Luiz Paulo; CARNEIRO, Paulo Campos
    Objective: To investigate Incidental Thyroid Carcinoma (ITC) by comparing the results of Fine Needle Aspiration Biopsy (FNAB) cytology and the postoperative pathological findings. Methods: Data of 1479 patients who underwent total thyroidectomy were retrieved. Three hundred eighty-six patients were excluded due to insufficient data. Each surgical specimen studied received two histopathological diagnoses: the local diagnosis - for the same area in which the FNAB was performed; and the final diagnosis, which includes a study of the entire surgical specimen. Results: A thousand and ninety-three patients were investigated. FNAB result was malignant in 187 patients, benign in 204, suspicious or indeterminate in 668 cases, and inconclusive in 34 cases. The prevalence of ITC was 15.1%. Most of the ITC in this series was less than 0.5 cm. The incidence of ITC was higher in Bethesda III (17.5% ITC) and IV (19% ITC) than in Bethesda II cases (1.5% false negatives and 9% ITC). Conclusion: Although the incidence of false-negative results in Bethesda II nodules is only 1.5%, 9% of these patients had ITC in the thyroid parenchyma outside the nodule that underwent preoperative FNAB. The incidence of ITC in the same scenario was even higher in Bethesda III (17.5%) and Bethesda IV cases (19%). Ultrasonography-guided FNAB is an excellent method for the assessment of thyroid nodules. However, biopsy sites should be carefully selected. Despite the high incidence of incidentalomas, total thyroidectomy should not always be the treatment of choice due to its rare but potentially serious complications. The findings of the present study can assist future clinical decisions towards active surveillance strategies for the management of papillary thyroid carcinoma.