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  • conferenceObject
    IN BOTH GENDERS, HIGH RATE UNESTERIFIED CHOLESTEROL TRANSFER TO HDL IN THE PLASMA CAN BE PROTECTIVE AGAINST CORONARY ARTERY DISEASE
    (2014) SPRANDEL, M. C. O.; HUEB, W. A.; SEGRE, A. C.; LAVERDY, O. G.; LEITE-JUNIOR, A. C.; FREITAS, F. R.; KALIL-FILHO, R.; MARANHAO, R. C.
  • article 8 Citação(ões) na Scopus
    Effects of Glycemic Control upon Serum Lipids and Lipid Transfers to HDL in Patients with Type 2 Diabetes Mellitus: Novel Findings in Unesterified Cholesterol Status
    (2015) LAVERDY, O. G.; HUEB, W. A.; SPRANDEL, M. C. O.; KALIL-FILHO, R.; MARANHAO, R. C.
    Objective: Investigate the relations of glycemic levels with plasma lipids and in vitro lipid transfers to HDL in patients with type 2 diabetes mellitus. Materials and Methods: 143 patients with type 2 diabetes not taking anti-lipidemic drugs were separated into 2 groups: group A included 62 patients with glycated hemoglobin (HbA(1c)) <= 6.5 % (48 mmol/mol) and group B 81 patients with HbA(1c) > 6.5 %. In vitro transfer of lipids was determined by 1 h incubation of a donor nanoemulsion containing radioactively labeled unesterified and esterified cholesterol, phospholipids and triglycerides with whole plasma followed by chemical precipitation and radioactive counting in the supernatant (HDL). Results: LDL and HDL cholesterol were similar in Group A and B, but group B had higher triglycerides (2.31 +/- 1.30 vs. 1.58 +/- 0.61 mmol/l, P < 0.0001) and total and non-HDL unesterified cholesterol (36.3 +/- 7.8 vs. 33.9 +/- 5.9 mmol/l, P < 0,05; 30.6 +/- 7.9 vs. 27.6 +/- 6.2 mmol/l, P < 0,05; respectively) than group A and a non-significant trend to increased apolipoprotein B (103 +/- 20 vs. 97 +/- 20 mg/dl, P = 0.08). 36 patients with the highest, >= 8.0 % (64 mmol/mol), HbA(1c) also showed non-significant trend of elevated non-esterified fatty acids (NEFA) compared to 37 with lowest, <= 6.0 % (42 mmol/mol), HbA(1c) (P = 0.08). Patients with higher NEFA had higher triglycerides than those with lower NEFA levels (P < 0.01). Transfers of all lipids from nanoemulsion to HDL and lipid composition of HDL were equal in both groups. Conclusions: For the first time it was shown that in addition to triglycerides, unesterified cholesterol is also a marker of poor glycemic control. In vitro HDL lipid transfers, an important aspect of HDL metabolism, were not related with the glycemic control.