LUCAS DE OLIVEIRA SERRA HORTENCIO

Índice h a partir de 2011
4
Projetos de Pesquisa
Unidades Organizacionais
Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina - Médico

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Agora exibindo 1 - 10 de 19
  • conferenceObject
    Association between Childhood Adversity and Ultra-High Risk for Psychosis Status in a Populational Sample of Sao Paulo, Brazil
    (2017) LOCH, Alexandre; ALVES, Tania Maria; FREITAS, Elder Lanzani; HORTENCIO, Lucas; ANDRADE, Julio Cesar; BILT, Martinus Theodorus van de; FONTONI, Marcos Roberto; SERPA, Mauricio; CHIANCA, Camille; GATTAZ, Wagner Farid; ROESSLER, Wulf
  • bookPart
    Centros de Atenção Psicossocial (CAPS)
    (2021) HORTêNCIO, Lucas de Oliveira Serra; CARDOSO, Flávia; BUONFIGLIO, Helena Bonadia
  • article 4 Citação(ões) na Scopus
    Motion energy analysis during speech tasks in medication-naive individuals with at-risk mental states for psychosis
    (2022) LOPES-ROCHA, Ana Caroline; CORCORAN, Cheryl Mary; ANDRADE, Julio Cesar; PERONI, Leonardo; HADDAD, Natalia Mansur; HORTENCIO, Lucas; SERPA, Mauricio Henriques; BILT, Martinus Theodorus van de; GATTAZ, Wagner Farid; LOCH, Alexandre Andrade
    Movement abnormalities are commonly observed in schizophrenia and at-risk mental states (ARMS) for psychosis. They are usually detected with clinical interviews, such that automated analysis would enhance assessment. Our aim was to use motion energy analysis (MEA) to assess movement during free-speech videos in ARMS and control individuals, and to investigate associations between movement metrics and negative and positive symptoms. Thirty-two medication-naive ARMS and forty-six healthy control individuals were filmed during speech tasks. Footages were analyzed using MEA software, which assesses movement by differences in pixels frame-by-frame. Two regions of interest were defined-head and torso-and mean amplitude, frequency, and coefficient of variability of movements for them were obtained. These metrics were correlated with the Structured Interview for Prodromal Syndromes (SIPS) symptoms, and with the risk of conversion to psychosis-inferred with the SIPS risk calculator. ARMS individuals had significantly lower mean amplitude of head movement and higher coefficients of movement variability for both head and torso, compared to controls. Higher coefficient of variability was related to higher risk of conversion. Negative correlations were seen between frequency of movement and most SIPS negative symptoms. All positive symptoms were correlated with at least one movement variable. Movement abnormalities could be automatically detected in medication-naive ARMS subjects by means of a motion energy analysis software. Significant associations of movement metrics with symptoms were found, supporting the importance of movement analysis in ARMS. This could be a potentially important tool for early diagnosis, intervention, and outcome prediction.
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    PERCEPTUAL ABNORMALITIES AND RELIGIOSITY IN ULTRA HIGH-RISK FOR PSYCHOSIS (UHR) INDIVIDUALS IN A LATIN AMERICAN POPULATIONAL SAMPLE RESULTS FROM THE SAO PAULO SSAPP COHORT
    (2018) LOCH, Alexandre; CHIANCA, Camille; FREITAS, Elder Lanzani; ANDRADE, Julio Cesar; ALVES, Tania Maria; SERPA, Mauricio Henriques; HORTENCIO, Lucas; BILT, Martinus Theodorus van de; GATTAZ, Wagner; ROSSLER, Wulf
  • bookPart
    Transtorno afetivo bipolar
    (2019) HORTêNCIO, Lucas de Oliveira Serra; ALMEIDA, Karla Mathias de; LAFER, Beny
  • conferenceObject
    Lithium may induce changes in renal tubular function and calcium homeostasis in patients with bipolar disorder
    (2017) HORTENCIO, L.; HELOU, C. M.; SILVA, M.; LAFER, B.; ALMEIDA, K.
  • conferenceObject
    ASSOCIATION BETWEEN CHILDHOOD ADVERSITY AND ULTRA-HIGH RISK FOR PSYCHOSIS STATUS IN A POPULATIONAL SAMPLE OF SAO PAULO, BRAZIL
    (2017) LOCH, Alexandre; ALVES, Tania Maria; FREITAS, Elder Lanzani; HORTENCIO, Lucas; ANDRADE, Julio Cesar; BILT, Martinus Theodorus van de; FONTONI, Marcos Roberto; SERPA, Mauricio; CHIANCA, Camille; GATTAZ, Wagner Farid; ROESSLER, Wulf
  • bookPart
    Delirium
    (2019) SILVA, Felipe Duarte; FERNANDES, Flávio Guimarães; HORTêNCIO, Lucas de Oliveira Serra; HUMES, Eduardo de Castro
  • article 3 Citação(ões) na Scopus
    Influence of migration on the thought process of individuals at ultra-high risk for psychosis
    (2021) NOGUEIRA, Arthur S.; ANDRADE, Julio C.; SERPA, Mauricio H.; ALVES, Tania M.; FREITAS, Elder L.; HORTENCIO, Lucas; BILT, Martinus T. van de; GATTAZ, Wagner F.; LOCH, Alexandre A.; ROSSLER, Wulf
    Objective: To assess the influence of migration on the psychopathological presentation of individuals at ultra-high risk for psychosis (UHR) in Sao Paulo, Brazil. Methods: This study is part of the Subclinical Symptoms and Prodromal Psychosis (SSAPP) project, a cohort study in Sao Paulo, Brazil, designed to follow individuals at UHR. After screening with the Prodromal Questionnaire (PQ) and a clinical interview, the Global Assessment of Functioning (GAF) was administered, a neuropsychological assessment was performed, sociodemographic and migration data were obtained. We then analyzed UHR individuals who had migration data to see if migration had any effect on their cognition and psychopathology. Chi-square tests were used for categorical variables, and Student's t test or analysis of variance (ANOVA) were used for nonparametric and parametric distributions, respectively. Results: The sample was composed of 42 at-risk subjects, of whom 5 had a migration history in the past two generations. Those with migration history showed significantly more formal thought disturbances (p = 0.012) and sleeping problems (p = 0.033) compared to those without. Conclusions: Our data reinforce migration as a risk factor for psychosis in developing countries as well, and highlights the importance of studying the specific effect of this factor in UHR psychopathology.Y
  • article 0 Citação(ões) na Scopus
    A dopamine receptor D2 genetic polymorphism associated with transition to mental disorders in a cohort of individuals with at-risk mental state for psychosis
    (2023) MARQUES, Julia Hatagami; TALIB, Leda Leme; HORTENCIO, Lucas; ANDRADE, Julio Cesar; ALVES, Tania Maria; SERPA, Mauricio Henriques; YAMAMOTO, Guilherme Lopes; BILT, Martinus Theodorus van de; ROSSLER, Wulf; GATTAZ, Wagner Farid; LOCH, Alexandre Andrade
    Objectives: To test the association of 45 single nucleotide polymorphisms (SNPs) with transition to psychiatric disorders in a cohort of individuals at ultrahigh risk (UHR) mental state for psychosis.Methods: Through general population screening, 88 non-help-seeking UHR subjects and 130 healthy control individuals were genotyped for 45 SNPs related to psychosis. They were followed for a mean of 2.5 years, and conversion to psychotic and to general psychiatric disorders was assessed. Genotype frequencies between controls, converters, and non-converters were analyzed.Results: There were no differences in sociodemographics between controls and UHR. Also, UHR converters and non-converters had no differences in their baseline symptoms scores. The dopamine receptor D2 gene (DRD2) SNP rs6277 was significantly more common among UHR who transitioned to psychosis (p o 0.001) and to UHR who transitioned to any psychiatric disorders (p = 0.001) when compared to UHR who did not transition. The rs6277 T allele was related to psychiatric morbidity in a dose-response fashion, being significantly more frequent in UHR converters than UHR non-converters and control subjects (p = 0.003).Conclusion: Our findings suggest that rs6277 could potentially constitute a genetic marker of transition to psychiatric disorders in subjects with at-risk mental states, warranting further investigation in larger samples.