(Fonte: Lattes)
Índice h a partir de 2011
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/16 - Laboratório de Fisiopatologia Renal, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/12 - Laboratório de Pesquisa Básica em Doenças Renais, Hospital das Clínicas, Faculdade de Medicina

Resultados de Busca

Agora exibindo 1 - 10 de 26
  • bookPart
    (2016) COSTALONGA, Elerson Carlos; SILVA, Verônica Torres Costa e
  • conferenceObject
    Performance of the 2021 CKD-EPI equations without a race coefficient in a multi-racial population of adults with solid tumors: A prospective cross-sectional study.
    (2022) SILVA, Veronica Torres Costa E; GIL- JR., Luiz A.; INKER, Lesley; CAIRES, Renato; COSTALONGA, Elerson; COURA-FILHO, George; ESTEVEZ-DIZ, Maria Del Pilar; CASTRO, Gilberto; MATHEW, Paul; LEVEY, Andrew; BURDMANN, Emmanuel de Almeida
  • article 21 Citação(ões) na Scopus
    A prospective cross-sectional study estimated glomerular filtration rate from creatinine and cystatin C in adults with solid tumors
    (2022) SILVA, Veronica T. Costa e; JR, Luiz A. Gil; INKER, Lesley A.; CAIRES, Renato A.; COSTALONGA, Elerson; COURA-FILHO, George; SAPIENZA, Marcelo T.; JR, Gilberto Castro; ESTEVEZ-DIZ, Maria Dp; ZANETTA, Dirce Maria T.; ANTONANGELO, Leila; MARCAL, Lia; TIGHIOUART, Hocine; MIAO, Shiyuan; MATHEW, Paul; LEVEY, Andrew S.; BURDMANN, Emmanuel A.
    Current guidelines recommend estimating glomerular filtration rate (eGFR) using creatinine (eGFRcr) with the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation as the first test for GFR evaluation, but the Cockcroft-Gault (CG) equation is still commonly used in oncology practice and clinical trials despite increasing evidence of its inaccuracy compared to measured GFR (mGFR). Guidelines recommend eGFR using cystatin C (eGFRcys) or both markers (eGFRcr-cys) as a confirmatory test, but neither was carefully evaluated in cancer patients. Therefore, we compared performance of the CKD-EPI equations and others to the CG equation in adults with a variety of solid tumors. The mGFR was determined by plasma clearance of Cr-51-EDTA. Bias was defined as the median of the differences between mGFR and eGFR while accuracy was defined as the percentage of estimates that differed by more than 30% from the measured GFR (1-P30). We prospectively recruited 1,200 patients between April 2015 and September 2017 with a mean age and mGFR of 58.8 years and 78.4 ml/min/1.73m 2 , respectively. Bias among eGFRcr equations varied from -8.1 to +6.1 ml/min/1.73 m(2). CG was the least accurate, 1-P30 (95% confidence interval) was 24.9 (22.4- 27.3)%; CKD-EPI had 1-P30 of 19.1 (16.8-21.2)% while eGFRcr-cys had the best performance: bias -2.0 (-2.6 to -1.1) ml/min/1.73m(2) and 1-P30 7.8 (6.3-9.4)%. Thus, the CG equation should not be preferred over CKD-EPI equation, and eGFRcr-cys can be used as a confirmatory test in adults with solid tumors. Hence, a major policy implication would be to adopt general practice guideline-recommended methods for GFR evaluation in oncology practice and clinical trials.
  • bookPart
    Nefrologia oncológica
    (2022) COSTALONGA, Elerson Carlos; CAIRES, Renato Antunes; SILVA, Verônica Torres Costa e
  • bookPart
    Insuficência renal aguda
    (2013) YU, Luís; SILVA, Verônica Torres da Costa e
  • article 31 Citação(ões) na Scopus
    Assessment of Kidney Function in Patients With Cancer
    (2018) SILVA, Veronica Torres da Costa e; COSTALONGA, Elerson C.; COELHO, Fernanda O.; CAIRES, Renato A.; BURDMANN, Emmanuel A.
    Cancer patients are living longer. The sequelae of cancer treatment and the role of comorbid conditions present before the diagnosis, such as CKD, have been increasingly recognized. The interface between CKD and cancer is multifaceted. CKD is frequently observed in patients with cancer, and cancer treatment contributes to CKD development and progression. In addition, CKD has been recognized as an important risk factor for cancer development and reduced specific cancer survival. In this context, an accurate evaluation of the glomerular filtration rate (GFR) during oncologic treatment is pivotal and is used to define surgery strategies, program prophylactic management of contrasted examinations, make decisions on cisplatin eligibility, and adjust drug prescriptions, particularly chemotherapy agents. Although the most commonly used equations to estimate GFR based on serum creatinine levels in clinical practice (Cockcroft-Gault, Modification of Diet in Renal Disease Study, and CKD Epidemiology Collaboration equations) have not been validated in patients with cancer in large prospective studies, there is increasingly evidence supporting the use of CKD Epidemiology Collaboration equation to assess the GFR in patients with cancer, including for the use of chemotherapy prescriptions. Many patients with cancer may have changes in nutrition status and clearance measurements such as exogenous filtration markers might be extremely useful when clinical decisions differ depending on the GFR level. Future perspectives include the advent of new serum GFR biomarkers such as cystatin C, beta-trace protein, and beta 2 microglobulin as well as the GFR assessment by measuring total kidney parenchymal volume through image examinations.
  • article 30 Citação(ões) na Scopus
    Cisplatin Based Chemoradiation Late Toxicities in Head and Neck Squamous Cell Carcinoma Patients
    (2015) RIVELLI, Thomas Giollo; MAK, Milena Perez; MARTINS, Renata Eiras; SILVA, Veronica Torres da Costa e; CASTRO JR., Gilberto de
    Background: Cisplatin-based chemoradiation (CRT) offers head and neck squamous cell carcinoma (HNSCC) patients better overall survival when compared to radiation alone. However, it also increases acute and late toxicity (LT). Here we aimed to review the main aspects of diagnosis and treatment of long-term toxicities in HNSCC patients after CRT. Methods: We crossed-searched PubMed MeshTerms: Survivors, Deglutition Disorders, Xerostomia, Hypothyroidism, Cisplatin, Kidney, Hearing, and Osteoradionecrosis, with keywords: ""Head and Neck Neoplasms"" and ""Chemoradiotherapy."" A total of 5,541 publications were retrieved and 48 were selected for this systematic review. Results: Dysphagia (25%), xerostomia (40-80%, depending on the technique used), hypothyroidism (42%), ototoxicity (27%), and osteoradionecrosis (4%) were the most commonly reported LT and were related to compromised quality of life aspects in HNSCC patients. Concurrent cisplatin and higher radiation doses, especially to normal tissue, increased the rates of LT. Conclusions: Late CRT toxicities were reported mostly in retrospective studies. Addressing these adverse effects as endpoints in future clinical trials is necessary to provide tools to prevent and treat them adequately, allowing better quality of life and survival results.
  • article 36 Citação(ões) na Scopus
    Performance of the third-generation models of severity scoring systems (APACHE IV, SAPS 3 and MPM-III) in acute kidney injury critically ill patients
    (2011) SILVA, Veronica Torres Costa e; CASTRO, Isac de; LIANO, Fernando; MURIEL, Alfonso; RODRIGUEZ-PALOMARES, Jose R.; YU, Luis
    Background. Severity scores are useful to guarantee similar disease severity among groups in clinical trials and to enable comparison between different studies. The aim of this study was to assess the performance of the third generation models of severity scoring systems [simplified acute physiology score (SAPS) 3, acute physiology and chronic health evaluation (APACHE) IV and mortality probability model (MPM)-III] in acute kidney injury (AKI) patients in the intensive care unit (ICU). Methods. Three hundred and sixty-six consecutive AKI critically ill patients were prospectively assessed in six ICUs of an academic tertiary care center. Scores were applied on AKI diagnosis day (DD) and on the day of nephrology consultation (NCD). Discrimination was assessed by area under the receiver operating characteristic curve (AUCROC) and calibration by Hosmer-Lemeshow (HL) goodness-of-fit test. Results. Hospital mortality rate was 67.8%. SAPS 3 general and Central and South America (CSA) customized equations presented identical good discrimination (AUCROC curve: 0.80 on NCD) and satisfactory HL tests on both analyzed days (P > 0.100). CSA SAPS 3 equation predicted mortality more accurately [standardized mortality ratio (SMR) on NCD = 1.00 (95% confidence interval (CI) 0.84-1.34)]. APACHE IV and MPM-III scores presented similar discrimination compared to SAPS 3 on both analyzed days (P > 0.05). APACHE IV presented satisfactory HL tests over time (P > 0.100) but underestimated mortality [SMR on DD 1.92 (95% CI 1.61-2.23); SMR on NCD 1.46 (95% CI 1.48-1.96)]. MPM-III showed unsatisfactory HL test results (P = 0.027 on DD; P = 0.045 on NCD) and underestimated mortality [SMR on NCD - 2.09 (95% CI 1.48-1.96)]. Conclusions. SAPS 3, especially the geographical customized equation, presented good discrimination and calibration performances, accurately predicting mortality in this group of AKI critically ill patients.
  • conferenceObject
    Predicting adverse outcomes after cisplatin administration in head & neck and thoracic cancer
    (2013) BITTON, R. C.; CASTRIA, T. B.; AMARAL, A. A.; LOLLO, J. G.; SILVA, V. T. Costa e; BUDMANN, E.; HOFF, P. M.; CASTRO JR., G.
  • article 63 Citação(ões) na Scopus
    Nephrology Referral and Outcomes in Critically Ill Acute Kidney Injury Patients
    (2013) SILVA, Veronica Torres Costa e; LIANO, Fernando; MURIEL, Alfonso; DIEZ, Rafael; CASTRO, Isac de; YU, Luis
    Background: Delayed nephrology consultation (NC) seems to be associated with worse prognosis in critically ill acute kidney injury (AKI) patients. Design, Setting, Participants, & Measurements: The aims of this study were to analyze factors related with timing of NC and its relation with AKI patients' outcome in intensive care units of a tertiary hospital. AKI was defined as an increase >= 50% in baseline serum creatinine (SCr). Early NC and delayed NC were defined as NC performed before and two days after AKI diagnosis day. Multivariable logistic regression and propensity scores (PS) were used to adjust for confounding and selection biases. Hospital mortality and dialysis dependence on hospital discharge were the primary outcomes. Results: A total of 366 AKI patients were analyzed and NCs were carried out in 53.6% of the patients. Hospital mortality was 67.8% and dialysis required in 31.4% patients (115/366). Delayed NCs (34%) occurred two days after AKI diagnosis day. This group presented higher mortality (OR: 4.04/CI: 1.60-10.17) and increased dialysis dependence (OR: 3.00/CI: 1.43-6.29) on hospital discharge. Four variables were retained in the PS model for delayed NC: diuresis (1000 ml/24 h-OR: 1.92/CI: 1.27-2.90), SCr (OR: 0.49/CI: 0.32-0.75), surgical AKI (OR: 3.67/CI: 1.65-8.15), and mechanical ventilation (OR: 2.82/CI: 1.06-7.44). After correction by PS, delayed NC was still associated with higher mortality (OR: 3.39/CI: 1.24-9.29) and increased dialysis dependence (OR: 3.25/CI: 1.41-7.51). Delayed NC was associated with increased mortality either in dialyzed patients (OR: 1.54/CI: 1.35-1.78) or non-dialyzed patients (OR: 2.89/CI: 1.00-8.35). Conclusion: Delayed NC was associated with higher mortality and increased dialysis dependence rates in critically ill AKI patients at hospital discharge. Further studies are necessary to ascertain whether this effect is due to delayed nephrology intervention or residual confounding factors.