LENA NABUCO DE ABREU

(Fonte: Lattes)
Índice h a partir de 2011
3
Projetos de Pesquisa
Unidades Organizacionais
LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina

Resultados de Busca

Agora exibindo 1 - 10 de 10
  • conferenceObject
    Impact of comorbid anxiety disorders in prospective suicide attempts
    (2015) ABREU, L. N.; LAFER, B.; BURKE, A.; GRUNEBAUM, M. F.; SHER, L.; SULLIVAN, G. M.; SUBLETTE, M. E.; PIETROBON, R.; VISSOCI, J. R.; MANN, J. J.; OQUENDO, M. A.
  • article 24 Citação(ões) na Scopus
    Are comorbid anxiety disorders a risk factor for suicide attempts in patients with mood disorders? A two-year prospective study
    (2018) ABREU, L. N.; OQUENDO, M. A.; GALFAVY, H.; BURKE, A.; GRUNEBAUM, M. F.; SHER, L.; SULLIVAN, G. M.; SUBLETTE, M. E.; MANN, J.; LAFER, B.
    Background: Comorbid anxiety disorders have been considered a risk factor for suicidal behavior in patients with mood disorders, although results are controversial. The aim of this two-year prospective study was to determine if lifetime and current comorbid anxiety disorders at baseline were risk factors for suicide attempts during the two-year follow-up. Methods: We evaluated 667 patients with mood disorders (504 with major depression and 167 with bipolar disorder) divided in two groups: those with lifetime comorbid anxiety disorders (n = 229) and those without (n = 438). Assessments were performed at baseline and at 3, 12, and 24 months. KaplanMeier survival analysis and log-rank test were used to evaluate the relationship between anxiety disorders and suicide attempts. Cox proportional hazard regression was performed to investigate clinical and demographic variables that were associated with suicide attempts during follow-up. Results: Of the initial sample of 667 patients, 480 had all three follow-up interviews. During the follow-up, 63 patients (13.1%) attempted suicide at least once. There was no significant difference in survival curves for patients with and without comorbid anxiety disorders (log-rank test = 0.269; P = 0.604). Female gender (HR = 3.66, P = 0.001), previous suicide attempts (HR = 3.27, P = 0.001) and higher scores in the Buss-Durkee Hostility Inventory (HR = 1.05, P = 0.001) were associated with future suicide attempts. Conclusions: Our results suggest that comorbid anxiety disorders were not risk factors for suicide attempts. Further studies were needed to determine the role of anxiety disorders as risk factors for suicide attempts.
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    Quality of life is associated with clinical outcome in BD: a longitudinal study
    (2018) SILVA, M.; BELIZARIO, G. O.; ABREU, L. N.; LAFER, B.
  • conferenceObject
    Hostility expression in pediatric bipolar disorder, healthy offspring and controls
    (2017) ROCCA, C.; GOMES, B.; BELIZARIO, G.; KLEINMAN, A.; ABREU, L.; CAETANO, S.; LAFER, B.; BUSATTO, G.
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    Comparison of comorbid anxiety disorders in suicide attempters with bipolar disorder and major depression
    (2013) ABREU, L. Nabuco de; LAFER, B.; BURKE, A.; GRUNEBAUN, M.; SHER, L.; SULLIVAN, G.; SUBLETTE, E.; MANN, J.; OQUENDO, M.
  • article 38 Citação(ões) na Scopus
    A Randomized Controlled Trial of Cognitive Behavioral Group Therapy for Bipolar Disorder
    (2011) GOMES, B. C.; ABREU, L. N.; BRIETZKE, E.; CAETANO, S. C.; KLEINMAN, A.; NERY, F. G.; LAFER, B.
    Background: This study evaluated the effectiveness of adjunctive cognitive behavioral group therapy (CBGT) to prevent recurrence of episodes in euthymic patients with bipolar disorder. Methods: A randomized controlled single-blind trial was conducted with 50 patients with bipolar disorder types I and II followed up for at least 12 months in an outpatient service and whose disease was in remission. An experimental CBGT manual was developed and added to treatment as usual (TAU), and results were compared with TAU alone. Results: Intention-to-treat analysis showed that there was no difference between groups in terms of time until any relapse (Wilcoxon = 0.667; p = 0.414). When considering type of relapse, there was still no difference in either depressive (Wilcoxon = 3.328; p = 0.068) or manic episodes (Wilcoxon = 1.498; p = 0.221). Although occurrence of episodes also did not differ between groups (chi(2) = 0.28; p = 0.59), median time to relapse was longer for patients treated with CBGT compared to TAU (Mann-Whitney = -2.554; p = 0.011). Conclusions:Time to recurrence and number of episodes were not different in the group of patients treated with CBGT. However, median time to relapse was shorter in the TAU group. Studies with larger samples may help to clarify whether our CBGT approach prevents new episodes of bipolar disorder. Our findings also indicated that CBGT is feasible in euthymic patients with bipolar disorder and should be investigated in future studies. To our knowledge, this is the first publication of a controlled trial of CBGT for euthymic patients with bipolar disorder.
  • article 47 Citação(ões) na Scopus
    Suicide attempts are associated with worse quality of life in patients with bipolar disorder type I
    (2012) ABREU, Lena Nabuco de; NERY, Fabiano G.; HARKAVY-FRIEDMAN, Jill M.; ALMEIDA, Karla Matias de; GOMES, Bernardo Carramao; OQUENDO, Maria A.; LAFER, Beny
    Background: The association between suicidal behavior and quality of life (QoL) in bipolar disorder (BD) is poorly understood. Worse QoL has been associated with suicide attempts and suicidal ideation in schizophrenic patients, but this relationship has not been investigated in BD. This study tested whether a history of suicide attempts was associated with poor QoL in a well-characterized sample of patients with BD, as has been observed in other psychiatric disorders and in the general population. Methods: One hundred eight patients with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition BD type I (44 with previous suicide attempts, 64 without previous suicide attempts) were studied. Quality of life was assessed using the World Health Organization's Quality of Life Instrument Short Version. Depressive and manic symptoms were assessed using the Hamilton Depression Rating Scale-17 items and the Young Mania Rating Scale. Results: Patients with BD and previous suicide attempts had significantly lower scores in all the 4 domains of the World Health Organization's Quality of Life Instrument Short Version scale than did patients with BD but no previous suicide attempts (physical domain P=.001; psychological domain P <.0001; social domain P=.001, and environmental domain P=.039). In the euthymic subgroup (n=70), patients with previous suicide attempts had significantly lower scores only in the psychological and social domains (P=.020 and P=.004). Limitations: This was a cross-sectional study, and no causal associations can be assumed. Conclusions: Patients with BD and a history of previous suicide attempts seem to have a worse QoL than did patients who never attempted suicide. Poorer QoL might be a marker of poor copying skills and inadequate social support and be a risk factor for suicidal behavior in BD. Alternatively, poorer QoL and suicidal behavior might be different expressions of more severe BD.
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    Impact of first-episode polarity on clinical features associated to suicide attempts in bipolar disorder type I patients
    (2012) ABREU, L. N.; NERY, F. G.; SCIPPA, A. M.; KAPCZINSKI, F.; LAFER, B.
    Background: Little attention has been drawn to the relationship between episode polarity at onset and its relationship with suicide attempts (SA) during the course of Bipolar Disorder (BD). Our aim was to compare clinical features between attempters and non-attempters with manic onset and depressive onset. Methods: We evaluated 376 outpatients with DSM-IV BD type I from the Brazilian Research Network. Participants were divided in two groups: manic onset (MO) (n = 146, 38.8%) and depressive onset (DO) (n = 230, 61.2%). Each subgroup was divided according the presence of lifetime suicide attempts (MO group: 52 attempters and 94 non-attempters; DO group: 95 attempters and 135 non-attempters). We compared the attempters and non-attempters of the two groups regarding demographic, clinical variables and outcome measures. Results: Stepwise logistic regression revealed that the following clinical features are associated with SA in MO patients: comorbid OCD (OR = 8.3 CI = 1.6–43.3 p = 0.01), alcohol dependence (OR = 4.7 CI = 1.4–15.8 p = 0.01), rapid cycling (OR = 4.2 CI = 1.3–13 p = 0.01) and agoraphobia (OR = 4.2 CI = 1.2–14.6 p = 0.02). For DO patients, the clinical features associated with SA were: presence of hospitalization (OR = 3.9 CI = 1.9–8 p £ 0.001), family history of completed suicide (OR = 2.9 CI = 1.3–6 p = 0.005), rapid cycling (OR = 2.7 CI = 1.2–5.7 p = 0.009) and female gender (OR = 2.2 CI = 1–5 p = 0.041). Conclusion: Risk factors for SA in MO patients are associated with rapid cycling and comorbidities with axis I disorders (OCD, alcohol dependence and agoraphobia) and in DO patients with features related to the course of illness (hospitalizations and rapid cycling), female gender and family history of completed suicide. Polarity of first episode may be important in determining different risk factors for suicide attempts in patients with Bipolar Disorder type I.
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    Risk factors for emergence of suicidal ideation in bipolar disorder: A 7-year prospective study
    (2019) ABREU, L. N. de; BELIZARIO, G. O.; LAFER, B.