(Fonte: Lattes)
Índice h a partir de 2011
Projetos de Pesquisa
Unidades Organizacionais
Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina

Resultados de Busca

Agora exibindo 1 - 10 de 16
  • bookPart
    Transtorno obsessivo- compulsivo
    (2023) GAZOTTI, Thaís de Castro; FENIMAN, Débora Chou; FERNANDES, Flávio Guimarães
  • bookPart
    O normal e o patológico em saúde mental
    (2023) VARGAS, Fábio Moreira; FERNANDES, Flávio Guimarães; CASTELLANA, Gustavo Bonini
  • article 4 Citação(ões) na Scopus
    Cold ischemia or topical-ECMO for lung preservation: a randomized experimental study
    (2014) MARIANI, Alessandro Wasum; MEDEIROS, Israel Lopes; PEGO-FERNANDES, Paulo Manuel; FERNANDES, Flavio Guimaraes; UNTERPERTINGUER, Fernando Do Vale; FERNANDES, Lucas Matos; CARDOSO, Paulo Francisco; CANZIAN, Mauro; JATENE, Fabio Biscegli
    CONTEXT AND OBJECTIVE: Lung preservation remains a challenging issue for lung transplantation groups. Along with the development of ex vivo lung perfusion, a new preservation method known as topical-ECMO (extracorporal membrane oxygenation) has been proposed. The present study compared topical-ECMO with cold ischemia (CI) for lung preservation in an ex vivo experimental model. DESIGN AND SETTING: Randomized experimental study, conducted at a public medical school. METHOD: Fourteen human lungs were retrieved from seven brain-dead donors that were considered unsuitable for transplantation. The lung bloc was divided and each lung was randomized to be preserved by means of topical-ECMO or CI (4-7 degrees C) for eight hours. These lungs were then reconnected to an ex vivo perfusion system for functional evaluation. Lung biopsies were obtained at three times. The functional variables assessed were oxygenation capacity (OC) and pulmonary artery pressure (PAP); and the histological variables were lung injury score (LIS) and apoptotic cell count (ACC). RESULTS: The mean OC was 468 mmHg (+/- 81.6) in the topical-ECMO group and 455.8 (+/- 54) for CI (P = 0.758). The median PAP was 140 mmHg (120-160) in the topical-ECMO group and 140 mmHg (140-150) for CI (P = 0.285). The mean LIS was 35.57 (+/- 4.5) in the topical-ECMO group and 33.86 (+/- 6.1) for CI (P = 0.367). The ACC was 25.00 (+/- 9.34) in the topical-ECMO group and 24.86(+/- 10.374) for CI (P = 0.803). CONCLUSIONS: The present study showed that topical-ECMO was not superior to cold ischemia for up to eight hours of lung preservation.
  • bookPart
    Pesquisa qualitativa
    (2021) GUIMARãES-FERNANDES, Flávio; CERON-LITVOC, Daniela; TURATO, Egberto Ribeiro
  • bookPart
    (2023) CASTELLANA, Gustavo Bonini; FERNANDES, Flávio Guimarães; ARATANGY, Eduardo Wagner; SALLET, Paulo Clemente
  • bookPart
    Exame do estado mental (psicopatologia)
    (2019) FERNANDES, Flávio Guimarães; SANT, Renato Del
  • article 1 Citação(ões) na Scopus
    Effect of methylprednisolone on perivascular pulmonary edema, inflammatory infiltrate, VEGF and TGF-beta immunoexpression in the remaining lungs of rats after left pneumonectomy
    Pneumonectomy is associated with high rates of morbimortality, with postpneumonectomy pulmonary edema being one of the leading causes. An intrinsic inflammatory process following the operation has been considered in its physiopathology. The use of corticosteroids is related to prevention of this edema, but no experimental data are available to support this hypothesis. We evaluated the effect of methylprednisolone on the remaining lungs of rats submitted to left pneumonectomy concerning edema and inflammatory markers. Forty male Wistar rats weighing 300 g underwent left pneumonectomy and were randomized to receive corticosteroids or not. Methylprednisolone at a dose of 10 mg/kg was given before the surgery. After recovery, the animals were sacrificed at 48 and 72 h, when the pO(2)/FiO(2) ratio was determined. Right lung perivascular edema was measured by the index between perivascular and vascular area and neutrophil density by manual count. Tissue expression of vascular endothelial growth factor (VEGF) and transforming growth factor-beta (TGF-beta) were evaluated by immunohistochemistry light microscopy. There was perivascular edema formation after 72 h in both groups (P = 0.0031). No difference was observed between operated animals that received corticosteroids and those that did not concerning the pO(2)/FiO(2) ratio, neutrophil density or TGF-beta expression. The tissue expression of VEGF was elevated in the animals that received methylprednisolone both 48 and 72 h after surgery (P = 0.0243). Methylprednisolone was unable to enhance gas exchange and avoid an inflammatory infiltrate and TGF-beta expression also showed that the inflammatory process was not correlated with pulmonary edema formation. However, the overexpression of VEGF in this group showed that methylprednisolone is related to this elevation.
  • bookPart
    Transtorno de personalidade borderline
    (2023) MIYAMOTO, William Isao; FERNANDES, Flávio Guimarães; CASTELLANA, Gustavo Bonini
  • bookPart
    O que é transtorno mental? Conceitos fundamentais sobre o diagnóstico em psiquiatria
    (2019) FERNANDES, Flávio Guimarães; CASTELLANA, Gustavo Bonini
  • bookPart
    A importância do hospital-dia na atenção terciária
    (2021) GUIMARãES-FERNANDES, Flávio; ALVES, Ana Laura Alcantara