Air pollution and high-intensity interval exercise: Implications to anti-inflammatory balance, metabolome and cardiovascular responses

dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCRUZ, Ramon
dc.contributor.authorKOCH, Sarah
dc.contributor.authorMATSUDA, Monique
dc.contributor.authorMARQUEZINI, Monica
dc.contributor.authorSFORCA, Mauricio L.
dc.contributor.authorLIMA-SILVA, Adriano E.
dc.contributor.authorSALDIVA, Paulo
dc.contributor.authorKOEHLE, Michael
dc.contributor.authorBERTUZZI, Romulo
dc.description.abstractHigh-intensity interval exercise (HIIE) is an effective non-pharmacological tool for improving physiological responses related to health. When HIIE is performed in urban centers, however, the exerciser is exposed to traffic-related air pollution (TRAP), which is associated with metabolic, anti-inflammatory imbalance and cardiovascular diseases. This paradoxical combination has the potential for conflicting health effects. Thus, the aim of this study was to determine the effects of HIIE performed in TRAP exposure on serum cytokines, non-target metabolomics and cardiovascular parameters. Fifteen participants performed HIIE in a chamber capable to deliver filtered air (FA condition) or non-filtered air (TRAP condition) from a polluted site adjacent to the exposure chamber. Non-target blood serum metabolomics, blood serum cytokines and blood pressure analyses were collected in both FA and TRAP conditions at baseline, 10 min after exercise, and 1 h after exercise. The TRAP increased IL-6 concentration by 1.7 times 1 h after exercise (p < 0.01) and did not change the anti-inflammatory balance (IL-10/TNF-alpha ratio). In contrast, FA led to an increase in IL-10 and IL-10/TNF-alpha ratio (p< 0.01), by 2.1 and 2.3 times, respectively. The enrichment analysis showed incomplete fatty acid metabolism under the TRAP condition (p < 0.05) 10 min after exercise. There was also an overactivity of ketone body metabolism (p < 0.05) at 10 min and at 1 h after exercise with TRAP. Exercise-induced acute decrease in systolic blood pressure (SBP) was not observed at 10min and impaired at 1 h after exercise (p < 0.05). These findings reveal that TRAP potentially attenuates health benefits often related to HIIE. For instance, the anti-inflammatory balance was impaired, accompanied by accumulation of metabolites related to energy supply and reduction to exercise-induced decrease in SBP.eng
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES)Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [001]
dc.description.sponsorshipNational Council for Scientific and Technological DevelopmentConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) [CNPq 301330/2019-0]
dc.identifier.citationSCIENCE OF THE TOTAL ENVIRONMENT, v.809, article ID 151094, 12p, 2022
dc.relation.ispartofScience of the Total Environment
dc.rights.holderCopyright ELSEVIEReng
dc.subjectParticulate mattereng
dc.subjectBlood pressureeng
dc.subjectHeart rate and vigorous exerciseeng
dc.subject.otherparticulate mattereng
dc.subject.wosEnvironmental Scienceseng
dc.titleAir pollution and high-intensity interval exercise: Implications to anti-inflammatory balance, metabolome and cardiovascular responseseng
dc.type.categoryoriginal articleeng
hcfmusp.affiliation.countryisoca, Ramon:Univ Sao Paulo, Sch Phys Educ & Sport, Endurance Performance Res Grp GEDAE USP, Sao Paulo, SP, Brazil; Univ Fed Santa Catarina, Sports Ctr, Dept Phys Educ, Florianopolis, SC, Brazil, Sarah:Univ British Columbia, Sch Kinesiol, Vancouver, BC, Canada; Barcelona Inst Global Hlth ISGlobal, Barcelona, Spain; Univ Pompeu Fabra UPF, Barcelona, Spain; CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain, Mauricio L.:Brazilian Ctr Res Energy & Mat CNPEM, Brazilian Biosci Natl Lab LNBio, Campinas, SP, Brazil, Adriano E.:Technol Fed Univ Parana, Acad Dept Phys Educ DAEFI, Human Performance Res Grp, Curitiba, Parana, Brazil, Paulo:Univ Sao Paulo, Inst Adv Studies, Sao Paulo, SP, Brazil, Michael:Univ British Columbia, Sch Kinesiol, Vancouver, BC, Canada; Univ British Columbia, Fac Med, Vancouver, BC, Canada, Romulo:Univ Sao Paulo, Sch Phys Educ & Sport, Endurance Performance Res Grp GEDAE USP, Sao Paulo, SP, Brazil
hcfmusp.citation.scopus10 MATSUDA VALERIA MARQUEZINI
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