Analysis of the acute systemic and tissue inflammatory response following carotid endarterectomy

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Citações na Scopus
4
Tipo de produção
article
Data de publicação
2016
Título da Revista
ISSN da Revista
Título do Volume
Editora
EDIZIONI MINERVA MEDICA
Autores
GABRIEL, Sthefano A.
BETELI, Camila B.
CAMARGO, Otacilio Jr De
AQUINO, Jose L. Braga De
CAFFARO, Roberto A.
Citação
INTERNATIONAL ANGIOLOGY, v.35, n.2, p.148-156, 2016
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
BACKGROUND: We aimed to investigate the acute systemic and tissue inflammatory response associated with carotid endarterectomy (CEA) and analyze the association between serum and tissue biomarkers and histological features of carotid plaques between symptomatic and asymptomatic patients. METHODS: We studied 11 patients (6 symptomatic and 5 asymptomatic) with >= 70% internal carotid stenosis treated with CEA. Serum expression of interleukin (IL) 1 beta, IL-4, IL-6, IL-8, IL-10, metalloproteinase (MMP) 8, MMP-9, tumor necrosis factor-alpha (TNF-alpha), high-sensitive C-reactive protein (hs-CRP), and vascular endothelial growth factor (VEGF) were measured in the preoperative period and 1, 6 and 24 hours after CEA. Assessment of tissue biomarkers (IL-1 beta, IL-4, IL-6, IL-8, IL-10, MMP-8, MIVIP-9, TNF-alpha, and VEGF) and histological analyses were performed on carotid plaques. RESULTS: Peak serum values for MMP-8, MMP-9, IL-6, and IL 10 were observed 6 hours after CEA, whereas for hs-CRP, TNF-alpha, and VEGF, they were identified 24 hours after the procedure. Symptomatic patients exhibited higher serum concentrations of MMP-8, MMP-9, IL-1 beta, IL-4, IL-8, hs-CRP and TNF-alpha and higher tissue concentrations of MMP-8, MMP-9, IL-1 beta, IL-6 and VEGF than asymptomatic patients. Significant difference was found between symptomatic and asymptomatic patients in tissue IL-6 levels (30.95 pg/mL and 9.33 pg/mL, respectively; P=0.028). CONCLUSIONS: Systemic and tissue inflammatory response occurs even after CEA, being observed important activity of inflammatory and anti-inflammatory cytokines at 6 and 24 hours after CEA. Symptomatic patients show higher concentrations of serum and tissue biomarkers in comparison to asymptomatic patients.
Palavras-chave
Biological Markers, Carotid Artery Diseases, Inflammation, Cytokines
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