Polymorphisms in Inflammasome' Genes and Susceptibility to HIV-1 Infection

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Citações na Scopus
64
Tipo de produção
article
Data de publicação
2012
Título da Revista
ISSN da Revista
Título do Volume
Editora
LIPPINCOTT WILLIAMS & WILKINS
Autores
GIRARDELLI, Martina
KAMADA, Anselmo J.
CROVELLA, Sergio
Citação
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, v.59, n.2, p.121-125, 2012
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The involvement of inflammasome genes in the susceptibility to HIV-1 infection was investigated. Twelve single nucleotide polymorphisms within NLRP1, NLRP3, NLRC4, CARD8, CASP1, and IL1B genes were analyzed in 150 HIV-1-infected Brazilian subjects and 158 healthy controls. The 2 polymorphisms rs10754558 in NLRP3 and rs1143634 in IL1B were significantly associated to the HIV-1 infection. These findings supported the previously hypothesized involvement of NALP3-inflammasome in HIV-1 pathogenesis, underlining once more the key role of inflammation and innate immunity in the susceptibility to HIV-1 infection.
Palavras-chave
genetics, HIV-1, inflammasome, IL-1 beta, innate immunity, NALP3/NLRP3, polymorphisms
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