Seroprevalence of hepatitis E in adults in Brazil: a systematic review and meta-analysis

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Citações na Scopus
24
Tipo de produção
article
Data de publicação
2019
Título da Revista
ISSN da Revista
Título do Volume
Editora
BMC
Citação
INFECTIOUS DISEASES OF POVERTY, v.8, article ID 3, 10p, 2019
Projetos de Pesquisa
Unidades Organizacionais
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Resumo
BackgroundHepatitis E virus (HEV) is a member of the Hepeviridae family; it has four main genotypes and one serotype. While genotypes 1 and 2 cause epidemic hepatitis and are transmitted via water and the fecal-oral route, genotypes 3 and 4 are zoonotic. In the various seroprevalence studies of hepatitis E in Brazil, the numbers reported vary widely and are difficult to interpret. The aim of this study was to analyze existing seroprevalence studies of hepatitis E in adults in Brazil.Main textWe searched the PubMed, Latin American and Caribbean Health Sciences and Embase databases for studies published from inception to May 12, 2018 concerning infection by HEV in Brazil without time period or language restrictions. We included studies that presented data concerning hepatitis E seroprevalence in adults in Brazil, had a sample size 50 patients and whose method used for the detection of anti-HEV was standardized and commercialized. We also evaluated the quality of the articles using a list of criteria that totalized 9 items. Of the 20 studies ultimately analyzed, 10 (50%) were from the southeast region of Brazil, 3 (15%) were from the central-west region, 3 (15%) were from the northern region, 2 (10%) were from the northeast region and 2 (10%) were from the southern region. Regarding the quality evaluation of the studies, the mean score was 5.6 (range: 4-8). The estimated overall seroprevalence of HEV infection in the adult population was 6.0% (95% CI: 5.0-7.0); in subgroup analyses, we observed that the prevalence of anti-HEV antibodies in blood donors was 7.0% (95% CI: 5.0-8.0), whereas in the general population, it was 3.0% (95% CI: 2.0-4.0).ConclusionsThe results of this systematic review indicate that there should be national investment in the prevention of hepatitis E virus infection in Brazil, including the implementation of improvements in basic sanitation and guidance regarding the appropriate handling of animal waste and the optimal cooking of vegetables, meat and their derivatives.
Palavras-chave
Hepatitis E, Hepatitis E virus, Brazil, Prevalence, Systematic review
Referências
  1. Barnaud E, 2012, APPL ENVIRON MICROB, V78, P5153, DOI 10.1128/AEM.00436-12
  2. Beale MA, 2011, VOX SANG, V100, P340, DOI 10.1111/j.1423-0410.2010.01412.x
  3. BEGG CB, 1994, BIOMETRICS, V50, P1088, DOI 10.2307/2533446
  4. Bortoliero André Luiz, 2006, Rev. Inst. Med. trop. S. Paulo, V48, P87, DOI 10.1590/S0036-46652006000200006
  5. Boutrouille A, 2007, J CLIN MICROBIOL, V45, P2009, DOI 10.1128/JCM.00235-07
  6. Brassard J, 2012, APPL ENVIRON MICROB, V78, P3763, DOI 10.1128/AEM.00251-12
  7. Bricks G, 2018, BRAZ J INFECT DIS, V22, P85, DOI 10.1016/j.bjid.2018.02.001
  8. Colson P, 2012, EMERG INFECT DIS, V18, P1361, DOI 10.3201/eid1808.111827
  9. Crossan C, 2012, EMERG INFECT DIS, V18, P2085, DOI 10.3201/eid1812.120924
  10. Cruells M R, 1997, Gastroenterol Hepatol, V20, P295
  11. dos Santos DCM, 2002, MEM I OSWALDO CRUZ, V97, P637, DOI 10.1590/S0074-02762002000500007
  12. Egger M, 1997, BMJ-BRIT MED J, V315, P629, DOI 10.1136/bmj.315.7109.629
  13. Feagins AR, 2008, INT J FOOD MICROBIOL, V123, P32, DOI 10.1016/j.ijfoodmicro.2007.11.068
  14. Feagins AR, 2007, J GEN VIROL, V88, P912, DOI 10.1099/vir.0.82613-0
  15. Ferreira AC, 2018, ARCH VIROL, V163, P43, DOI 10.1007/s00705-017-3562-3
  16. Focaccia R, 1998, BRAZ J INFECT DIS, V2, P269
  17. Gao SY, 2015, INT J ENV RES PUB HE, V12, P2026, DOI 10.3390/ijerph120202026
  18. Goncales NSL, 2000, CLIN DIAGN LAB IMMUN, V7, P813, DOI 10.1128/CDLI.7.5.813-816.2000
  19. Hartl J, 2016, VIRUSES-BASEL, V8, DOI 10.3390/v8080211
  20. Higgins JPT, 2008, STAT MED, V27, P6072, DOI 10.1002/sim.3427
  21. Ibarra H, 1997, REV MED CHILE, V125, P275
  22. Jeblaoui A, 2013, CLIN INFECT DIS, V57, pE122, DOI 10.1093/cid/cit291
  23. Kaufmann A, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0021150
  24. Kiesslich D, 2002, T ROY SOC TROP MED H, V96, P215, DOI 10.1016/S0035-9203(02)90311-1
  25. Kmush B, 2013, SEMIN LIVER DIS, V33, P15, DOI 10.1055/s-0033-1338111
  26. Kokkinos P, 2012, FOOD ENVIRON VIROL, V4, P179, DOI 10.1007/s12560-012-9087-8
  27. Lewis HC, 2010, EPIDEMIOL INFECT, V138, P145, DOI 10.1017/S0950268809990847
  28. dos Santos DRL, 2010, J CLIN VIROL, V47, P276, DOI 10.1016/j.jcv.2009.12.021
  29. Mansuy JM, 2011, EMERG INFECT DIS, V17, P2309, DOI 10.3201/eid1712.110371
  30. Wassaf MGM, 2014, J CLIN VIROL, V61, P334, DOI 10.1016/j.jcv.2014.08.016
  31. Martins RMB, 2014, J CLIN VIROL, V59, P188, DOI 10.1016/j.jcv.2014.01.002
  32. Meng XJ, 2013, SEMIN LIVER DIS, V33, P41, DOI 10.1055/s-0033-1338113
  33. Meng XJ, 1998, J VIROL, V72, P9714
  34. Moher D, 2009, BMJ-BRIT MED J, V339, DOI [10.1016/j.jclinepi.2010.03.004, 10.1136/bmj.b2535, 10.1002/14651858.CD008242.pub3, 10.1002/14651858.CD008216.pub4, 10.1371/journal.pmed.1000097, 10.1016/j.jclinepi.2010.02.006, 10.1136/bmj.c869]
  35. Munn Z, 2015, INT J EVID-BASED HEA, V13, P147, DOI 10.1097/XEB.0000000000000054
  36. de Oliveira JMNS, 2018, INT J INFECT DIS, V69, P41, DOI 10.1016/j.ijid.2018.01.032
  37. PANG L, 1995, AM J TROP MED HYG, V52, P347, DOI 10.4269/ajtmh.1995.52.347
  38. Parana R, 1997, AM J TROP MED HYG, V57, P60, DOI 10.4269/ajtmh.1997.57.60
  39. Passos AM, 2013, J MED VIROL, V85, P615, DOI 10.1002/jmv.23494
  40. Passos-Castilho AM, 2017, BRAZ J INFECT DIS, V21, P535, DOI 10.1016/j.bjid.2017.05.004
  41. Passos-Castilho AM, 2016, BRAZ J INFECT DIS, V20, P262, DOI 10.1016/j.bjid.2016.03.001
  42. Passos-Castilho AM, 2016, J MED VIROL, V88, P361, DOI 10.1002/jmv.24336
  43. Song YJ, 2010, J MED VIROL, V82, P583, DOI 10.1002/jmv.21730
  44. Tei S, 2003, LANCET, V362, P371, DOI 10.1016/S0140-6736(03)14025-1
  45. Teshale EH, 2015, J INFECT DIS, V211, P366, DOI 10.1093/infdis/jiu466
  46. Trinta KS, 2001, MEM I OSWALDO CRUZ, V96, P25, DOI 10.1590/S0074-02762001000100004
  47. Vitral CL, 2014, BMC INFECT DIS, V14, DOI 10.1186/1471-2334-14-458
  48. Yu YH, 2009, INFECT GENET EVOL, V9, P554, DOI 10.1016/j.meegid.2009.02.008