Penile alterations with severe sperm abnormalities in antiphospholipid syndrome associated with systemic lupus erythematosus

dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorRABELO-JUNIOR, Carlos Nobre
dc.contributor.authorBONFA, Eloisa
dc.contributor.authorCARVALHO, Jozelio F.
dc.contributor.authorCOCUZZA, Marcello
dc.contributor.authorSAITO, Osmar
dc.contributor.authorABDO, Carmita H.
dc.contributor.authorSILVA, Clovis A.
dc.date.accessioned2013-09-23T16:36:13Z
dc.date.available2013-09-23T16:36:13Z
dc.date.issued2013
dc.description.abstractThis study aims to perform global gonadal and sexual function assessments in systemic lupus erythematosus-related antiphospholipid syndrome (SLE-APS) patients. A cross-sectional study was conducted in ten SLE-APS male patients and 20 healthy controls. They were assessed by demographic data, clinical features, urological examination, sexual function, testicular ultrasound, seminal parameters, sperm antibodies, and hormone profile. The median of current age was similar in SLE-APS patients and controls with a higher frequency of erectile dysfunction in the former group (30 vs. 0 %, p = 0.029). The median penis circumference was significantly reduced in SLE-APS patients with erectile dysfunction compared to patients without this complication (8.17 vs. 9.14 cm, p = 0.0397). SLE-APS patients with previous arterial thrombosis had a significantly reduced median penis circumference compared to those without this complication (7.5 vs. 9.18 cm, p = 0.039). Comparing SLE-APS patients and controls, the former had a significant lower median of sperm concentration (41.1 vs. 120.06 x 10(6)/mL, p = 0.003), percentages of sperm motility (47.25 vs. 65.42 %, p = 0.047), normal sperm forms by WHO guidelines (11 vs. 23.95 %, p = 0.002), and Kruger criteria (2.65 vs. 7.65 %, p = 0.02). Regarding seminal analysis, the medians of sperm concentration and total sperm count were significantly lower in SLE-APS patients treated with intravenous cyclophosphamide vs. those untreated with this drug (p < 0.05). Therefore, we have observed a novel association of reduced penile size with erectile dysfunction and previous arterial thrombosis in SLE-APS patients. Penis assessment should be routinely done in SLE-APS patients with fertility problems. We also identified that intravenous cyclophosphamide underlies severe sperm alterations in these patients.
dc.description.indexMEDLINE
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2004/07832-2, 2005/56482-7]
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPQ [301411/2009-3, 3300665/2009-1, 302724/2011-7]
dc.description.sponsorshipFederico Foundation
dc.description.sponsorshipNucleo de Apoio a Pesquisa Saude da Crianca e do Adolescente da USP
dc.identifier.citationCLINICAL RHEUMATOLOGY, v.32, n.1, p.109-113, 2013
dc.identifier.doi10.1007/s10067-012-2083-4
dc.identifier.issn0770-3198
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/1796
dc.language.isoeng
dc.publisherSPRINGER LONDON LTD
dc.relation.ispartofClinical Rheumatology
dc.rightsrestrictedAccess
dc.rights.holderCopyright SPRINGER LONDON LTD
dc.subjectAntiphospholipid syndrome
dc.subjectAntisperm antibodies
dc.subjectErectile dysfunction
dc.subjectFertility
dc.subjectPenile
dc.subjectSperm
dc.subjectSystemic lupus erythematosus
dc.subject.otherjuvenile dermatomyositis
dc.subject.othergonad evaluation
dc.subject.otherdisease-activity
dc.subject.otherclassification
dc.subject.othercriteria
dc.subject.otherindex
dc.subject.wosRheumatology
dc.titlePenile alterations with severe sperm abnormalities in antiphospholipid syndrome associated with systemic lupus erythematosus
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.citation.scopus20
hcfmusp.contributor.author-fmusphcCARLOS NOBRE RABELO JUNIOR
hcfmusp.contributor.author-fmusphcELOISA SILVA DUTRA DE OLIVEIRA BONFA
hcfmusp.contributor.author-fmusphcJOZELIO FREIRE DE CARVALHO
hcfmusp.contributor.author-fmusphcMARCELLO ANTONIO SIGNORELLI COCUZZA
hcfmusp.contributor.author-fmusphcOSMAR DE CASSIO SAITO
hcfmusp.contributor.author-fmusphcCARMITA HELENA NAJJAR ABDO
hcfmusp.contributor.author-fmusphcCLOVIS ARTUR ALMEIDA DA SILVA
hcfmusp.description.beginpage109
hcfmusp.description.endpage113
hcfmusp.description.issue1
hcfmusp.description.volume32
hcfmusp.origemWOS
hcfmusp.origem.pubmed22965775
hcfmusp.origem.scopus2-s2.0-84873405495
hcfmusp.origem.wosWOS:000314272200015
hcfmusp.publisher.cityLONDON
hcfmusp.publisher.countryENGLAND
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hcfmusp.remissive.sponsorshipCNPq
hcfmusp.remissive.sponsorshipFAPESP
hcfmusp.remissive.sponsorshipFederico Foundation
hcfmusp.remissive.sponsorshipUSP
hcfmusp.remissive.sponsorshipCNPq
hcfmusp.remissive.sponsorshipFAPESP
hcfmusp.remissive.sponsorshipFederico Foundation
hcfmusp.remissive.sponsorshipUSP
hcfmusp.scopus.lastupdate2024-06-09
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