Living Related Donor Liver Transplantation in Children

dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorTANNURI, A. C. A.
dc.contributor.authorGIBELLI, N. E. M.
dc.contributor.authorRICARDI, L. R. S.
dc.contributor.authorSANTOS, M. M.
dc.contributor.authorMAKSOUD-FILHO, J. G.
dc.contributor.authorPINHO-APEZZATO, M. L.
dc.contributor.authorSILVA, M. M.
dc.contributor.authorVELHOTE, M. C. P.
dc.contributor.authorAYOUB, A. A. R.
dc.contributor.authorANDRADE, W. C.
dc.contributor.authorLEAL, A. J.
dc.contributor.authorMIYATANI, H. T.
dc.contributor.authorTANNURI, U.
dc.date.accessioned2017-11-27T16:20:33Z
dc.date.available2017-11-27T16:20:33Z
dc.date.issued2011
dc.description.abstractObjective. The objective of this study was to report our experience with pediatric orthotopic liver transplantation (OLT) with living related donors. Methods. We performed a retrospective chart analysis of 121 living related donor liver transplantations (LRDLT) from June 1998 to June 2010. Results. Indications were biliary atresia (BA; n = 81), primary sclerosing cholangitis (n = 5), alpha-1 antitrypsin deficiency (n = 4); cholestasis (n = 9), fulminant hepatic failure (n = 8), autoimmune hepatitis (n = 2), Alagille syndrome (n = 4), hepatoblastoma (n = 3), tyrosinemia (n = 2), and congenital hepatic fibrosis (n = 3). The age of the recipients ranged from 7-174 months (median, 22) and the weights ranged from 6-58 kg (median, 10). Forty-nine children (40.5%) weighed <= 10 kg. The grafts included the left lateral segment (n = 108), the left lobe (n = 12), and the right lobe (n = 1). The donors included 71 mothers, 45 fathers, 2 uncles, 1 grandmother, 1 grandfather, and 1 sister with a median age of 29 years (range, 16-53 ys) and a median weight of 68 kg (range, 47-106). Sixteen patients (12.9%) required retransplantation, most commonly due to hepatic artery thrombosis (HAT; n = 13; 10.7%). The other complications were biliary stenosis (n = 25; 20.6%), portal vein thrombosis (PVT; n = 11; 9.1%), portal vein stenosis (n = 5; 4.1%), hepatic vein stenosis (n = 6; 4.9%), and lymphoproliferative disorders (n = 8; 6.6%). The ultimate survival rate of recipients was 90.3% after 1 year and 75.8% after 3 years. Causes of early death within 1 month were HAT (n = 6), PVT (n = 2), severe graft dysfunction (n = 1), sepsis (n = 1), and intraoperative death in children with acute liver failure (n = 2). Causes of late deaths included lymphoproliferative disease (n = 3), chronic rejection (n = 2), biliary complications (n = 3), and recurrent disease (n = 3; hepatoblastoma and primary sclerosing cholangitis). Conclusions. Despite the heightened possibility of complications (mainly vascular), LRDLT represented a good alternative to transplantation from cadaveric donors in pediatric populations. It was associated with a high survival ratio.
dc.description.conferencedateOCT 02-05, 2010
dc.description.conferencelocalPorto, PORTUGAL
dc.description.conferencename9th Luso Brazilian Congress of Transplant
dc.description.indexMEDLINE
dc.identifier.citationTRANSPLANTATION PROCEEDINGS, v.43, n.1, p.161-164, 2011
dc.identifier.doi10.1016/j.transproceed.2010.11.013
dc.identifier.issn0041-1345
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/22444
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INC
dc.relation.ispartofTransplantation Proceedings
dc.rightsrestrictedAccess
dc.rights.holderCopyright ELSEVIER SCIENCE INC
dc.subject.otherbiliary complications
dc.subject.otherhepatic-artery
dc.subject.otherreconstruction
dc.subject.otherexperience
dc.subject.otherthrombosis
dc.subject.wosImmunology
dc.subject.wosSurgery
dc.subject.wosTransplantation
dc.titleLiving Related Donor Liver Transplantation in Children
dc.typearticle
dc.type.categoryarticle; proceedings paper
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalRICARDI, L. R. S.:Univ Sao Paulo, Fac Med, Dept Pediat,Hosp Clin, Pediat Surg & Liver Transplantat Div,Inst Crianca, BR-01246903 Sao Paulo, Brazil
hcfmusp.citation.scopus37
hcfmusp.contributor.author-fmusphcANA CRISTINA AOUN TANNURI
hcfmusp.contributor.author-fmusphcNELSON ELIAS MENDES GIBELLI
hcfmusp.contributor.author-fmusphcMARIA MERCES SANTOS
hcfmusp.contributor.author-fmusphcJOAO GILBERTO MAKSOUD FILHO
hcfmusp.contributor.author-fmusphcMARIA LUCIA DE PINHO APEZZATO
hcfmusp.contributor.author-fmusphcMARCOS MARQUES DA SILVA
hcfmusp.contributor.author-fmusphcMANOEL CARLOS PRIETO VELHOTE
hcfmusp.contributor.author-fmusphcALI ABDUL RAHMAN AYOUB
hcfmusp.contributor.author-fmusphcWAGNER DE CASTRO ANDRADE
hcfmusp.contributor.author-fmusphcANTONIO JOSE GONCALVES E LEAL
hcfmusp.contributor.author-fmusphcHELENA THIE MIYATANI
hcfmusp.contributor.author-fmusphcUENIS TANNURI
hcfmusp.description.beginpage161
hcfmusp.description.endpage164
hcfmusp.description.issue1
hcfmusp.description.volume43
hcfmusp.origemWOS
hcfmusp.origem.pubmed21335177
hcfmusp.origem.scopus2-s2.0-79951775691
hcfmusp.origem.wosWOS:000287679100031
hcfmusp.publisher.cityNEW YORK
hcfmusp.publisher.countryUSA
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hcfmusp.scopus.lastupdate2024-06-09
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