COVID-19 salivary signature: diagnostic and research opportunities

dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSAPKOTA, Dipak
dc.contributor.authorSOLAND, Tine Merete
dc.contributor.authorGALTUNG, Hilde Kanli
dc.contributor.authorSAND, Lars Peter
dc.contributor.authorGIANNECCHINI, Simone
dc.contributor.authorTO, Kelvin K. W.
dc.contributor.authorMENDES-CORREA, Maria Cassia
dc.contributor.authorGIGLIO, Daniel
dc.contributor.authorHASSEUS, Bengt
dc.contributor.authorBRAZ-SILVA, Paulo Henrique
dc.description.abstractThe COVID-19 (caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)) epidemic started in Wuhan (Hubei Province, China) in mid-December 2019 and quickly spread across the world as a pandemic. As a key to tracing the disease and to implement strategies aimed at breaking the chain of disease transmission, extensive testing for SARS-CoV-2 was suggested. Although nasopharyngeal/oropharyngeal swabs are the most commonly used biological samples for SARS-CoV-2 diagnosis, they have a number of limitations related to sample collection and healthcare personnel safety. In this context, saliva is emerging as a promising alternative to nasopharyngeal/oropharyngeal swabs for COVID-19 diagnosis and monitoring. Saliva collection, being a non-invasive approach with possibility for self-collection, circumvents to a great extent the limitations associated with the use of nasopharyngeal/oropharyngeal swabs. In addition, various salivary biomarkers including the salivary metabolomics offer a high promise to be useful for better understanding of COVID-19 and possibly in the identification of patients with various degrees of severity, including asymptomatic carriers. This review summarises the clinical and scientific basis for the potential use of saliva for COVID-19 diagnosis and disease monitoring. Additionally, we discuss saliva-based biomarkers and their potential clinical and research applications related to COVID-19.eng
dc.identifier.citationJOURNAL OF CLINICAL PATHOLOGY, v.74, n.6, p.344-349, 2021
dc.relation.ispartofJournal of Clinical Pathology
dc.rights.holderCopyright BMJ PUBLISHING GROUPeng
dc.subjectdiagnostic techniques and procedureseng
dc.subjectmolecular biologyeng
dc.subjectsalivary glandseng
dc.titleCOVID-19 salivary signature: diagnostic and research opportunitieseng
hcfmusp.affiliation.countryisose, Dipak:Univ Oslo, Fac Dent, Dept Oral Biol, Oslo, Norway, Tine Merete:Univ Oslo, Fac Dent, Dept Oral Biol, Oslo, Norway; Rikshosp Univ Hosp, Dept Pathol, Oslo, Norway, Hilde Kanli:Univ Oslo, Fac Dent, Dept Oral Biol, Oslo, Norway, Lars Peter:Univ Oslo, Fac Dent, Dept Oral Biol, Oslo, Norway, Simone:Univ Firenze, Dept Expt & Clin Med, Florence, Toscana, Italy, Kelvin K. W.:Univ Hong Kong, Dept Microbiol, State Key Lab Emerging Infect Dis, Li KaShing Fac Med, Hong Kong, Peoples R China; Queen Mary Hosp, Dept Microbiol, Hong Kong, Peoples R China; Univ Hong Kong, Dept Clin Microbiol & Infect Control, Shenzhen Hosp, Shenzhen, Peoples R China, Daniel:Univ Gothenburg, Sahlgrenska Acad, Dept Clin Oncol, Gothenburg, Sweden, Bengt:Univ Gothenburg, Sahlgrenska Acad, Inst Odontol, Dept Oral Med & Pathol, Gothenburg, Sweden; Reg Vastra Gotaland, Clin Oral Med, Gothenburg, Sweden CASSIA JACINTHO MENDES CORREA HENRIQUE BRAZ DA SILVA
hcfmusp.relation.referenceAro K, 2017, FRONT PUBLIC HEALTH, V5, DOI 10.3389/fpubh.2017.00077eng
hcfmusp.relation.referenceAzzi L, 2020, J INFECTION, V81, pE45, DOI 10.1016/j.jinf.2020.04.005eng
hcfmusp.relation.referenceBanoei MM, 2017, CRIT CARE, V21, DOI 10.1186/s13054-017-1672-7eng
hcfmusp.relation.referenceBarton LM, 2020, AM J CLIN PATHOL, V153, P725, DOI [10.1093/AJCP/AQAA062, 10.1093/ajcp/aqaa062]eng
hcfmusp.relation.referenceCanatan Duran, 2020, Acta Biomed, V91, P195, DOI 10.23750/abm.v91i2.9534eng
hcfmusp.relation.referenceCastro T, 2018, J ORAL MICROBIOL, V10, DOI 10.1080/20002297.2018.1510712eng
hcfmusp.relation.referenceChandler JD, 2016, AM J PHYSIOL-REG I, V311, pR906, DOI 10.1152/ajpregu.00298.2016eng
hcfmusp.relation.referenceChen LZJ, 2020, SSRNeng
hcfmusp.relation.referenceChen NS, 2020, LANCET, V395, P507, DOI 10.1016/S0140-6736(20)30211-7eng
hcfmusp.relation.referenceChen Y, 2020, J MED VIROL, V92, P418, DOI 10.1002/jmv.25681eng
hcfmusp.relation.referenceCoutard B, 2020, ANTIVIR RES, V176, DOI 10.1016/j.antiviral.2020.104742eng
hcfmusp.relation.referenceCruz HM, 2019, BMC INFECT DIS, V19, DOI 10.1186/s12879-019-4183-0eng
hcfmusp.relation.referenceFehr AR, 2017, ANNU REV MED, V68, P387, DOI 10.1146/annurev-med-051215-031152eng
hcfmusp.relation.referenceSampaio BCF, 2020, BRAZ J INFECT DIS, V24, P51, DOI 10.1016/j.bjid.2019.11.005eng
hcfmusp.relation.referenceGalhardo LF, 2020, EUR J CLIN INVEST, V50, DOI 10.1111/eci.13219eng
hcfmusp.relation.referenceGoldansaz SA, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0177675eng
hcfmusp.relation.referenceGorbalenya AE, 2020, NAT MICROBIOL, V5, P536, DOI 10.1038/s41564-020-0695-zeng
hcfmusp.relation.referenceBraz-Silva PH, 2021, ORAL DIS, V27, P746, DOI 10.1111/odi.13365eng
hcfmusp.relation.referenceHuang CL, 2020, LANCET, V395, P497, DOI 10.1016/S0140-6736(20)30183-5eng
hcfmusp.relation.referenceHung IFN, 2020, LANCET, V395, P1695, DOI 10.1016/S0140-6736(20)31042-4eng
hcfmusp.relation.referenceKaczor-Urbanowicz KE, 2017, EXP BIOL MED, V242, P459, DOI 10.1177/1535370216681550eng
hcfmusp.relation.referenceKojima NTF., 2020, MEDRXIVeng
hcfmusp.relation.referenceLeon-Icaza SA., 2019, EXRNA, V1, DOI [10.1186/s41544-018-0004-7, DOI 10.1186/S41544-018-0004-7]eng
hcfmusp.relation.referenceLi RY, 2020, SCIENCE, V368, P489, DOI 10.1126/science.abb3221eng
hcfmusp.relation.referenceLima DP, 2010, INT J INFECT DIS, V14, pE184, DOI 10.1016/j.ijid.2009.04.022eng
hcfmusp.relation.referenceLin CY, 2020, CLIN CHEM LAB MED, V58, P1089, DOI 10.1515/cclm-2020-0187eng
hcfmusp.relation.referenceLiu L, 2011, J VIROL, V85, P4025, DOI 10.1128/JVI.02292-10eng
hcfmusp.relation.referenceLiu R, 2020, CLIN CHIM ACTA, V505, P172, DOI 10.1016/j.cca.2020.03.009eng
hcfmusp.relation.referenceLu BJ, 2010, IMMUNOLOGY, V130, P254, DOI 10.1111/j.1365-2567.2010.03231.xeng
hcfmusp.relation.referenceMalamud Daniel, 2011, Dent Clin North Am, V55, P159, DOI 10.1016/j.cden.2010.08.004eng
hcfmusp.relation.referenceMarques JS, 2018, MEDIAT INFLAMM, V2018, DOI 10.1155/2018/6020625eng
hcfmusp.relation.referenceMartelli F, 2018, VIRUS RES, V249, P1, DOI 10.1016/j.virusres.2018.03.002eng
hcfmusp.relation.referenceO'Brien J, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00402eng
hcfmusp.relation.referencePang JX, 2020, J CLIN MED, V9, DOI 10.3390/jcm9030623eng
hcfmusp.relation.referencePasomsub E, 2021, CLIN MICROBIOL INFEC, V27, DOI 10.1016/j.cmi.2020.05.001eng
hcfmusp.relation.referencePortilho M, 2017, ORAL DIS, V23, P1072, DOI 10.1111/odi.12692eng
hcfmusp.relation.referenceSapkota D, 2020, BRIT DENT J, V228, P658, DOI 10.1038/s41415-020-1594-7eng
hcfmusp.relation.referenceShen B, 2020, CELL, V182, P59, DOI 10.1016/j.cell.2020.05.032eng
hcfmusp.relation.referenceSong J, 2020, J MED VIROL, V92, P2556, DOI 10.1002/jmv.26045eng
hcfmusp.relation.referenceSullivan Patrick Sean, 2020, JMIR Public Health Surveill, V6, pe19054, DOI 10.2196/19054eng
hcfmusp.relation.referenceTo KKW, 2019, CLIN MICROBIOL INFEC, V25, P372, DOI 10.1016/j.cmi.2018.06.009eng
hcfmusp.relation.referenceTo KKW, 2020, LANCET INFECT DIS, V20, P565, DOI 10.1016/S1473-3099(20)30196-1eng
hcfmusp.relation.referenceTo KKW, 2020, CLIN INFECT DIS, V71, P841, DOI 10.1093/cid/ciaa149eng
hcfmusp.relation.referenceWHO, 2020, 125 WHOeng
hcfmusp.relation.referenceWilliams E, 2020, J CLIN MICROBIOL, V58, DOI 10.1128/JCM.00776-20eng
hcfmusp.relation.referenceWrapp D, 2020, SCIENCE, V367, P1260, DOI [10.1126/science.abb2507, 10.1101/2020.02.11.944462]eng
hcfmusp.relation.referenceWu CR, 2020, ACTA PHARMACOL SIN B, V10, P766, DOI 10.1016/j.apsb.2020.02.008eng
hcfmusp.relation.referenceWu D, 2020, NATL SCI REVeng
hcfmusp.relation.referenceWu JG, 2020, TRAVEL MED INFECT DI, V37, DOI 10.1016/j.tmaid.2020.101673eng
hcfmusp.relation.referenceWu Q, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-09536-zeng
hcfmusp.relation.referenceWyllie AL FJ., 2020, MEDRXIVeng
hcfmusp.relation.referenceXie CB, 2020, INT J INFECT DIS, V93, P264, DOI 10.1016/j.ijid.2020.02.050eng
hcfmusp.relation.referenceXu H, 2020, INT J ORAL SCI, V12, DOI 10.1038/s41368-020-0074-xeng
hcfmusp.relation.referenceXu J, 2020, J DENT RES, V99, P989, DOI 10.1177/0022034520918518eng
hcfmusp.relation.referenceZanin M, 2016, CELL HOST MICROBE, V19, P159, DOI 10.1016/j.chom.2016.01.001eng
hcfmusp.relation.referenceZhang CZ, 2016, INT J ORAL SCI, V8, P133, DOI 10.1038/ijos.2016.38eng
hcfmusp.relation.referenceZhao JJ, 2020, CLIN INFECT DIS, V71, P2027, DOI 10.1093/cid/ciaa344eng
hcfmusp.relation.referenceZhou P, 2020, NATURE, V579, P270, DOI 10.1038/s41586-020-2012-7eng
hcfmusp.relation.referenceZhu N, 2020, NEW ENGL J MED, V382, P727, DOI 10.1056/NEJMoa2001017eng
hcfmusp.relation.referenceZiegler CGK, 2020, CELL, V181, P1016, DOI 10.1016/j.cell.2020.04.035eng
Pacote Original
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
683.91 KB
Adobe Portable Document Format
publishedVersion (English)