Impact of Surgery for Deep Infiltrative Endometriosis before In Vitro Fertilization: A Systematic Review and Meta-analysis

dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCASALS, Gemma
dc.contributor.authorCARRERA, Maria
dc.contributor.authorDOMINGUEZ, Jose Antonio
dc.contributor.authorABRAO, Mauricio Simoes
dc.contributor.authorCARMONA, Francisco
dc.description.abstractObjective: The aims of this systematic review and meta-analysis were to compare reproductive outcomes in patients who underwent surgery for deep infiltrative endometriosis (DIE) before in vitro fertilization (IVF) with those in patients who underwent IVF without a previous surgery for DIE, to analyze data according to different types of surgery (complete or incomplete) or subgroups of patients (DIE with or without bowel involvement), and to assess surgical and IVF complications and data regarding safety concerns. Data Sources: A systematic literature search from January 1980 to November 2019 with no language restriction was performed in PubMed, MEDLINE, Embase, and Web of Science. The search strategy used the following Medical Subject Headings terms: ""in vitro,"" ""fertilization,"" ""IVF,"" ""assisted reproduction,"" ""colorectal,"" ""endometriosis,"" ""deep,"" ""infiltrating,"" ""deep infiltrative endometriosis,"" ""intestinal,"" ""bowel,"" ""rectovaginal,"" ""uterosacral,"" ""vaginal,"" and ""bladder."" Methods of Study Selection: We included studies that compared reproductive outcomes in women with infertility with DIE who received IVF with or without a previous surgery for DIE lesions. Meta-analysis was performed using Review Manager (RevMan v.5.3; Cochrane Training, London, United Kingdom). The risk of bias of the included studies was assessed using the method recommended by Cochrane Collaboration. Tabulation, Integration, and Results: The systematic search retrieved 150 articles; 98 studies were potentially eligible, and their full texts were reviewed. Of these, 12 studies met our inclusion criteria, and 5 presented data suitable for inclusion in a meta-analysis; however, 2 of the studies provided overlapping data, and only the larger study was finally included. No randomized controlled trials (RCTs) were found. The pregnancy rate per patient was 1.84 (95% confidence interval [CI], 1.28-2.64), the pregnancy rate per cycle was 1.84 (95% CI, 1.26-2.70), and the live birth rate per patient was 2.22 (95% CI, 1.42-3.46) times more likely for operated patients than for nonoperated ones. The addition of data from the incomplete surgery groups also showed a higher pregnancy rate per patient for surgery before IVF (odds ratio [OR] 1.63; 95% CI, 1.16-2.28). The results favor previous surgery in DIE with digestive involvement (OR 2.43; 95% CI, 1.13-5.22) and also in DIE without digestive involvement (OR 1.55; 95% CI, 0.61-3.95). A qualitative analysis of the complications of surgery and IVF showed a partial or complete lack of information on these issues as well as high heterogeneity in the reported data. None of these studies is an RCT; therefore, all have a high risk of selection and allocation bias, except for 1 study that statistically controlled the latter risk by using propensity scores. Funnel plots showed no asymmetry. Conclusion: The results were very consistent for all the studied outcomes, showing a statistically significant benefit for surgery before IVF, although they should be confirmed with RCTs. In addition to the reproductive outcomes, safety data should also be reported to obtain a complete assessment of the risks and benefits.eng
dc.identifier.citationJOURNAL OF MINIMALLY INVASIVE GYNECOLOGY, v.28, n.7, p.1303-+, 2021
dc.relation.ispartofJournal of Minimally Invasive Gynecology
dc.rights.holderCopyright ELSEVIER SCIENCE INCeng
dc.subjectColorectal endometriosiseng
dc.subjectAssisted reproductioneng
dc.subjectReproductive outcomeseng
dc.subject.othercumulative pregnancy rateeng
dc.subject.othercolorectal endometriosiseng
dc.subject.otherlaparoscopic resectioneng
dc.subject.otherbowel endometriosiseng
dc.subject.wosObstetrics & Gynecologyeng
dc.titleImpact of Surgery for Deep Infiltrative Endometriosis before In Vitro Fertilization: A Systematic Review and Meta-analysiseng
hcfmusp.affiliation.countryisoes, Gemma:Univ Barcelona, Hosp Clin Barcelona, Inst Invest Biomed August Pi i Sunyer, Dept Gynecol,Fac Med, Barcelona, Spain, Maria:Hosp Univ Doce Octubre, Assisted Reprod Unit, Madrid, Spain, Jose Antonio:Ctr Cirugia Minima Invas Jesus Uson, Inst Extremeno Reprod Asistida IERA Badajoz Lisbo, Caceres, Spain, Francisco:Univ Barcelona, Hosp Clin Barcelona, Inst Invest Biomed August Pi i Sunyer, Dept Gynecol,Fac Med, Barcelona, Spain
hcfmusp.citation.scopus35 SIMOES ABRAO
hcfmusp.publisher.cityNEW YORKeng
hcfmusp.relation.referenceAbrao MS, 2015, HUM REPROD UPDATE, V21, P329, DOI 10.1093/humupd/dmv003eng
hcfmusp.relation.referenceAlshehre SM, 2021, ARCH GYNECOL OBSTET, V303, P3, DOI 10.1007/s00404-020-05796-9eng
hcfmusp.relation.reference[Anonymous], 2014, REV MAN REVMANeng
hcfmusp.relation.referenceBallester M, 2017, EUR J OBSTET GYN R B, V209, P95, DOI 10.1016/j.ejogrb.2016.02.020eng
hcfmusp.relation.referenceBallester M, 2012, HUM REPROD, V27, P1043, DOI 10.1093/humrep/des012eng
hcfmusp.relation.referenceBallester M, 2012, FERTIL STERIL, V97, P367, DOI 10.1016/j.fertnstert.2011.11.022eng
hcfmusp.relation.referenceBarri PN, 2010, REPROD BIOMED ONLINE, V21, P179, DOI 10.1016/j.rbmo.2010.04.026eng
hcfmusp.relation.referenceBendifallah S, 2018, SURG ENDOSC, V32, P2003, DOI 10.1007/s00464-017-5896-zeng
hcfmusp.relation.referenceBendifallah S, 2017, FERTIL STERIL, V108, P525, DOI 10.1016/j.fertnstert.2017.07.002eng
hcfmusp.relation.referenceBianchi PHM, 2009, J MINIM INVAS GYN, V16, P174, DOI 10.1016/j.jmig.2008.12.009eng
hcfmusp.relation.referenceCapelle A, 2015, GYNECOL OBSTET FERTI, V43, P109, DOI 10.1016/j.gyobfe.2014.12.003eng
hcfmusp.relation.referenceCentini G, 2016, J MINIM INVAS GYN, V23, P113, DOI 10.1016/j.jmig.2015.09.015eng
hcfmusp.relation.referenceChapron C, 2019, NAT REV ENDOCRINOL, V15, P666, DOI 10.1038/s41574-019-0245-zeng
hcfmusp.relation.referenceCohen J, 2014, Minerva Ginecol, V66, P575eng
hcfmusp.relation.referenceDarai E, 2017, EUR J OBSTET GYN R B, V209, P86, DOI 10.1016/j.ejogrb.2016.05.024eng
hcfmusp.relation.referencede Ziegler D, 2010, LANCET, V376, P730, DOI 10.1016/S0140-6736(10)60490-4eng
hcfmusp.relation.referenceDonnez J, 2010, HUM REPROD, V25, P1949, DOI 10.1093/humrep/deq135eng
hcfmusp.relation.referenceDubernard G, 2006, HUM REPROD, V21, P1243, DOI 10.1093/humrep/dei491eng
hcfmusp.relation.referenceDuepree HJ, 2002, J AM COLL SURGEONS, V195, P754, DOI 10.1016/S1072-7515(02)01341-8eng
hcfmusp.relation.referenceDunselman GAJ, 2014, HUM REPROD, V29, P400, DOI 10.1093/humrep/det457eng
hcfmusp.relation.referenceGiudice LC, 2010, NEW ENGL J MED, V362, P2389, DOI 10.1056/NEJMcp1000274eng
hcfmusp.relation.referenceGuerriero S, 2018, ULTRASOUND OBST GYN, V51, P586, DOI 10.1002/uog.18961eng
hcfmusp.relation.referenceGupta S, 2008, FERTIL STERIL, V90, P247, DOI 10.1016/j.fertnstert.2008.02.093eng
hcfmusp.relation.referenceHamdan M, 2015, HUM REPROD UPDATE, V21, P809, DOI 10.1093/humupd/dmv035eng
hcfmusp.relation.referenceHiggins J.P.T., 2011, Cochrane handbook for systematic reviews of interventions: Version 5.1.0, DOI 10.1002/9780470712184eng
hcfmusp.relation.referenceHudelist G, 2018, ACTA OBSTET GYN SCAN, V97, P1438, DOI 10.1111/aogs.13436eng
hcfmusp.relation.referenceIversen ML, 2017, ACTA OBSTET GYN SCAN, V96, P688, DOI 10.1111/aogs.13152eng
hcfmusp.relation.referenceJohnson N, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD002125.pub3eng
hcfmusp.relation.referenceJohnson NP, 2013, HUM REPROD, V28, P1552, DOI 10.1093/humrep/det050eng
hcfmusp.relation.referenceKeckstein J, 2005, MINIM INVASIV THER, V14, P160, DOI 10.1080/14017430510035916eng
hcfmusp.relation.referenceLeone Roberti Maggiore U, 2018, FERTIL STERIL, V109, P942eng
hcfmusp.relation.referenceMacer ML, 2012, OBSTET GYN CLIN N AM, V39, P535, DOI 10.1016/j.ogc.2012.10.002eng
hcfmusp.relation.referenceMaggiore ULR, 2017, FERTIL STERIL, V108, P895, DOI 10.1016/j.fertnstert.2017.10.035eng
hcfmusp.relation.referenceMaggiore ULR, 2017, FERTIL STERIL, V107, DOI 10.1016/j.fertnstert.2017.02.106eng
hcfmusp.relation.referenceMaignien C, 2017, AM J OBSTET GYNECOL, V216, DOI 10.1016/j.ajog.2016.11.1042eng
hcfmusp.relation.referenceMattos LA, 2019, J MINIM INVAS GYN, V26, P1016, DOI 10.1016/j.jmig.2019.02.017eng
hcfmusp.relation.referenceMeuleman C, 2014, ANN SURG, V259, P522, DOI 10.1097/SLA.0b013e31828dfc5ceng
hcfmusp.relation.referenceMoher D, 2009, ANN INTERN MED, V151, pW264eng
hcfmusp.relation.referenceMounsambote L, 2017, GYNECOL OBST FERT SE, V45, P15, DOI 10.1016/j.gofs.2016.12.008eng
hcfmusp.relation.referenceNetter A, 2019, HUM REPROD, V34, P2144, DOI 10.1093/humrep/dez188eng
hcfmusp.relation.referencePractice Comm Amer Soc Reprod Med, 2012, FERTIL STERIL, V98, P591, DOI 10.1016/j.fertnstert.2012.05.031eng
hcfmusp.relation.referenceRoman H, 2017, J GYNECOL OBSTET HUM, V46, P159, DOI 10.1016/j.jogoh.2016.09.004eng
hcfmusp.relation.referenceRoman H, 2018, HUM REPROD, V33, P1669, DOI 10.1093/humrep/dey146eng
hcfmusp.relation.referenceRoman H, 2018, HUM REPROD, V33, P47, DOI 10.1093/humrep/dex336eng
hcfmusp.relation.referenceRoman H, 2015, J MINIM INVAS GYN, V22, P1059, DOI 10.1016/j.jmig.2015.05.023eng
hcfmusp.relation.referenceRubod C, 2019, J GYNECOL OBSTET HUM, V48, P235, DOI 10.1016/j.jogoh.2018.06.002eng
hcfmusp.relation.referenceRuffo G, 2010, SURG ENDOSC, V24, P63, DOI 10.1007/s00464-009-0517-0eng
hcfmusp.relation.referenceSeyer-Hansen M, 2018, ACTA OBSTET GYN SCAN, V97, P47, DOI 10.1111/aogs.13253eng
hcfmusp.relation.referenceSomigliana E, 2004, HUM REPROD, V19, P168, DOI 10.1093/humrep/deg513eng
hcfmusp.relation.referenceSoriano D, 2016, J MINIM INVAS GYN, V23, P781, DOI 10.1016/j.jmig.2016.03.015eng
hcfmusp.relation.referenceStepniewska A, 2009, HUM REPROD, V24, P1619, DOI 10.1093/humrep/dep083eng
hcfmusp.relation.referenceThe National Institute for Health and Care Excellence, 2017, END DIAGN MANeng
hcfmusp.relation.referenceUccella S, 2019, AM J PERINAT, V36, pS91, DOI 10.1055/s-0039-1692130eng
hcfmusp.relation.referenceVercellini P, 2018, HUM REPROD, V33, P1205, DOI 10.1093/humrep/dey104eng
hcfmusp.relation.referenceVercellini P, 2012, REPROD BIOMED ONLINE, V24, P389, DOI 10.1016/j.rbmo.2012.01.003eng
hcfmusp.relation.referenceWu CQ, 2019, J MINIM INVAS GYN, V26, P299, DOI 10.1016/j.jmig.2018.08.029eng
Pacote Original
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
1.98 MB
Adobe Portable Document Format
publishedVersion (English)